(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Yap
Definition:
(v. i.) To bark; to yelp.
(n.) A bark; a yelp.
Example Sentences:
(1) Treatment of Daudi B lymphoblastoid cells with interferon (IFN)-alpha or -beta has been reported (Yap, W. H., Teo, T. S., and Tan, Y. H. (1986) Science 234, 355-358) to cause a transient increase in the level of diacylglycerol, which is the endogenous activator of protein kinase C (PK-C).
(2) The plasma was activated with zymosan (ZAP, n = 4), yeast cells (YAP, n = 4) or yeast with 3 microM indomethacin (Indo + YAP, n = 3).
(3) In addition, she had discontinued chewing betel nut that was used daily by virtually all of her fellow islanders on Yap.
(4) DNA-affinity blots of proteins from YAP1 cells suggest the presence of additional TGACTCA-binding proteins other than GCN4 and yAP-1.
(5) I was surprised by the soundman's impatient intrusiveness and yet more surprised as I stood just off set, beside the faux-newsroom near the pseudo-researchers who appear on camera as pulsating set dressing, when the soundman yapped me to heel with the curt entitlement of Idi Amin's PA.
(6) The amino terminus of yAP-1 is homologous to the carboxy-terminal DNA-binding domains of GCN4 and c-Jun.
(7) Better to look at how Conservative MPs with elections to win responded rather than listen to the yapping of their followers.
(8) And just as Mikey-Michael is reckoning that Eranga has yapped himself out of focus, he hammers down one that's absurdly short and outside leg, so Ali gets right on top of it and spanks a swivel-pull around the corner for four.
(9) Yorkshire terrier Duffy is yapping away, the silver pillars are being polished and plastic sheeting being torn off surfaces.
(10) Soon enough, Giroud is making a nuisance of himself down the left, yapping at Odemwingie's heels, the Nigerian striker having chased back to mop up a loose ball.
(11) Also note-worthy is that GCN4 can bind to a GCN4 recognition element (GCRE) and to the ARE with approximately equal affinities; yAP-1, however, has a much lower affinity for the GCRE than the ARE, suggesting that yAP-1 can discriminate between these elements in vivo.
(12) At other points of the match, Mourinho could be seen gesturing for Wenger that it was time he stopped yapping away at the officials.
(13) Near the exit, as Rudd makes his way towards the bar, a dog yaps in the corner.
(14) Perfused dog lung lobes were exposed to plasma activated with yeast (YAP) or zymosan (ZAP).
(15) Recently, using molecular hybridization techniques with albumin [3H]cDNA, we have determined that in normally fed rats 98% of total liver polyribosomal albumin mRNA sequences are found in membrane-bound polyribosomes (Yap, S. H., Strair, R. K., and Shafritz, D. A.
(16) Musicians accounted for seven of the 10 most popular YouTube channels in the second half of 2013, with Katy Perry, One Direction, Rihanna and Thai music channel GMM Grammy joining MÜ-YAP and Miley in the upper reaches of the YouTube rankings.
(17) PGI2 biosynthesis was negligible in the control period, but started immediately after exposure to ZAP or YAP.
(18) Recently, we (Klein & Levi, 1987; Levi, Klein & Yap, 1988) suggested that two sensory processes may serve to limit position acuity, and thus contribute to Weber's law for position.
(19) More than 300 YAP clients have been interviewed regarding sexual behavior, suicide attempts, drug use, and experiences in disclosing their homosexuality to peers and parents during their high school years.
(20) Information obtained from clinical experiences of the University of Minnesota Youth and AIDS Project (YAP), a primary AIDS prevention program for gay and bisexual males ages 14-21, is described.