(a.) Not fixed or firm; liable to change; unstable; of a changeable mind; not firm in opinion or purpose; inconstant; capricious; as, Fortune's fickle wheel.
Example Sentences:
(1) Light testing equipment is fickle by nature, making such units uncommon.
(2) Over the last five years in particular, the main parties' opinion poll ratings have been strikingly fickle.
(3) This was a risky proposition that depended on the good will of gentrifiers, who are famously fickle.
(4) Vinny's fame was quick, fickle and fizzled out a generation ago, hence leaving him quite literally sleeping in a skip, pickled by booze.
(5) It is also unthinking because it takes little account of the pending impact of the falling terms of trade and the sluggish domestic economy, which is being held back by chronic weakness in consumer sentiment and fickle business conditions.
(6) They were there to record everything from his despair at the fickleness of his recruits, to the distress of his wife Jools at the way the media had invaded their privacy, with scurrilous rumours of infidelity.
(7) Bowie wasn't a traditional pop star, happy to be known for one sound or idea then to be discarded by a fickle public.
(8) Washington has long been a fan of the petro-dollar and Obama is proving another fickle enthusiast, flirting with the industry one moment, even as he snaps at it the next – like the coquettish mistress of an oil tycoon.
(9) Could he build a winner to win over sometimes fickle Miami fans?
(10) Raquel Paiva, professor of communications at the Federal University of Rio de Janeiro, said Brazil was a fickle nation that would probably soon forget this humiliation.
(11) The digital audience is more fickle: we have multiple subscriptions to magazines and newspapers; we leave a spray of comments on different websites.
(12) It is a strange and fickle beast, a flexible friend, dubious and duplicitous, as I was about to find out.
(13) How fickle the rest of the country is to forget its history at the expense of cheaper foreign imports.
(14) These moves are significant because the above list includes some strongly backed National candidates – especially Goold, who led the Headlong company, and Featherstone – but no recent appointee to another theatre could now express interest in Hytner's job without disqualifying themselves because of the appearance of fickleness.
(15) Bernard had become well aware of the fickle ways of Fleet Street and had become canny.
(16) At nearly 50, Ross will need to remain in the public eye lest the fickle world of TV starts to forget about him, but there are other ways of staying noticed in the digital era.
(17) The Scottish National party has repeatedly claimed that English and Welsh politicians would force Scotland to accept cuts or the loss of the Barnett formula if there was a no vote, accusing Westminster parties of being fickle.
(18) While the site is still sizeable it has lost users, business and momentum – extremely dangerous territory for anyone in the fickle internet business.
(19) Given the fickle and hypercritical nature of the group, in conceiving Spamalot Idle had to manage his expectations.
(20) She experienced something that transcended her pretty fickle and changeable musical allegiances.
Sickle
Definition:
(n.) A reaping instrument consisting of a steel blade curved into the form of a hook, and having a handle fitted on a tang. The sickle has one side of the blade notched, so as always to sharpen with a serrated edge. Cf. Reaping hook, under Reap.
(n.) A group of stars in the constellation Leo. See Illust. of Leo.
Example Sentences:
(1) In addition, congenital anemias such as sickle cell disease can impact on the health of the mother and fetus.
(2) Sickle and normal discocytes both showed membrane elasticity with reversion to original cell shape following release of the cell from its aspirated position at the pipette tip.
(3) Fourier transform infrared (FTIR) spectroscopy was used to examine the effect of oxysterol insertion into normal and sickle RBC membranes and the total lipid extracts of the membranes.
(4) The initial screening failed to detect sickle cell anemia in 4 infants, but the hemoglobinopathy in 3 of these infants was diagnosed correctly by routine retesting of those with suspected sickle cell trait.
(5) The sources were two adolescent patients with sickle cell disease and aplastic crisis who had unsuspected parvovirus infection.
(6) Thus, an abnormality of neutrophil oxidative metabolism cannot explain the propensity to bacterial infections in sickle cell disease.
(7) In order to examine sickle cell blood flow during MR imaging in vivo, laser-Doppler velocimetry was performed in normal control subjects and in sickle cell subjects before, during, and after MR imaging at 0.35 and 1.5 T. Mean blood flow and patterns of blood-flow variability were compared by two hematologists.
(8) Calcium-dependent ATPase, adenylate cyclase and phosphorylation of erythrocyte membrane proteins have been found abnormal in various conditions: hereditary spherocytosis, sickle-cell anemia, progressive muscular dystrophies, all of these disorders being associated with a decreased deformability of the erythrocyte.
(9) Sickle cell anemia and other hemoglobinopathies represent a major health problem in the United States.
(10) This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.
(11) We present a boy with sickle cell glomerulopathy and FSGS who is younger than patients with similar findings reported previously.
(12) Disruption of normal blood flow patterns in the medulla with impairment of function of the loop of Henle (functional papillectomy), presumably because of sickling in the hyperosmolar and anoxic environment of the renal medulla, may mediate these abnormalities.
(13) A study was conducted in a sample of 140 children with sickle cell anemia to evaluate the relationship between hematological variables (%HbF, %HbA2, %Hb, and mean cell volume) and disease severity.
(14) These include diseases diagnosed by restriction-site variation, such as Duchenne's muscular dystrophy and sickle cell anemia, those due to a collection of known mutations, such as beta-thalassemia, and those due to gene deletion, such as alpha-thalassemia.
(15) You’d think Michael Foot himself was running, attending debates in a hammer and sickle-print donkey jacket, from the amount we’ve been talking about him.
(16) Although these diseases are routinely screened for at birth, there is no general strategy among district health authorities for sickle cell screening.
(17) When red cells were loaded with Ca2+ using Ionophore A23187, both normal and sickle red cells enhanced their phosphorylation and sickle red cells to a greater extent than normal red cells.
(18) Nearly all sickle cell anemia patients carried the beta S mutation on a chromosome with haplotype 19 (or Benin) and all had severe anemia with sickling complications.
(19) The agent 12C79 which increases the oxygen affinity of sickle cells in vivo and prevent HbS polymerization is in clinical development.
(20) The results indicated that sickle cell patients have significant psychosocial distress in the areas of employment and finances, sleeping and eating, and performance of normal daily activities.