(superl.) Not coarse; comminuted; in small particles; as, fine sand or flour.
(superl.) Not thick or heavy; slender; filmy; as, a fine thread.
(superl.) Thin; attenuate; keen; as, a fine edge.
(superl.) Made of fine materials; light; delicate; as, fine linen or silk.
(superl.) Having (such) a proportion of pure metal in its composition; as, coins nine tenths fine.
(superl.) (Used ironically.)
(a.) To make fine; to refine; to purify, to clarify; as, to fine gold.
(a.) To make finer, or less coarse, as in bulk, texture, etc.; as. to fine the soil.
(a.) To change by fine gradations; as (Naut.), to fine down a ship's lines, to diminish her lines gradually.
(n.) End; conclusion; termination; extinction.
(n.) A sum of money paid as the settlement of a claim, or by way of terminating a matter in dispute; especially, a payment of money imposed upon a party as a punishment for an offense; a mulct.
(n.) A final agreement concerning lands or rents between persons, as the lord and his vassal.
(n.) A sum of money or price paid for obtaining a benefit, favor, or privilege, as for admission to a copyhold, or for obtaining or renewing a lease.
(n.) To impose a pecuniary penalty upon for an offense or breach of law; to set a fine on by judgment of a court; to punish by fine; to mulct; as, the trespassers were fined ten dollars.
(v. i.) To pay a fine. See Fine, n., 3 (b).
(v. t.) To finish; to cease; or to cause to cease.
Example Sentences:
(1) The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy.
(2) As a group, the three mammalian proteins resemble bovine serum conglutinin and behave as lectins with rather broad sugar specificities directed at certain non-reducing terminal N-acetylglucosamine, mannose, glucose and fucose residues, but with subtle differences in fine specificities.
(3) On the way back to Pristina later, the lawyer told me everything was fine.
(4) The move would require some secondary legislation; higher fines for employers paying less than the minimum wage would require new primary legislation.
(5) The surface of all cells was covered by a fuzzy coat consisting of fine hairs or bristles.
(6) The fine needle aspiration cytology features of twelve peripherally located bronchioloalveolar cell carcinomas of the lung diagnosed by fine needle aspiration biopsy are described.
(7) Recognition of this deficiency in our knowledge spurred a belated explosion of research that began with an exploration of the fine structure of the mesothelium.
(8) There were pronounced differences from the fine structural aspects in late infantile cases.
(9) TCR beta chain gene expression of individual T cell clones that share the same MHC class II restriction and similar fine specificity for the encephalitogenic NH2 terminus of the autoantigen myelin basic protein (MBP) has been examined.
(10) The use of sigma 54 promoters, known to require cognate binding proteins, could allow the fine-tuning that provides the temporal ordering of flagellar gene transcription.
(11) While there has been almost no political reform during their terms of office, there have been several ambitious steps forward in terms of environmental policy: anti-desertification campaigns; tree planting; an environmental transparency law; adoption of carbon targets; eco-services compensation; eco accounting; caps on water; lower economic growth targets; the 12th Five-Year Plan; debate and increased monitoring of PM2.5 [fine particulate matter] and huge investments in eco-cities, "clean car" manufacturing, public transport, energy-saving devices and renewable technology.
(12) That, however, is reserved for the most serious cases and the indications are that a fine is the likely outcome.
(13) These findings in a patient with acute leukaemia are strongly suspicious of fungal infection, and percutaneous fine-needle aspiration under ultrasound or computed tomography-guidance is indicated.
(14) Any MP who claims this is not statutory regulation is a liar, and should be forced to retract and apologise, or face a million pound fine.
(15) There’s a fine line between pushing them to their limits and avoiding injury, and Alberto is a master at it.
(16) While circulating the quarries is illegal – you risk a fine of up to €60 – neither the IGC nor the police seem to mind the veteran cataphiles who possess a good knowledge of the underground space, and who respect their heritage.
(17) No differences in cell fine structure or in growth factor requirements for cell proliferation were noted between normal and CF cells.
(18) of complete tryptic digests of the IRBPs indicate that, although they have in common a similar preponderance of hydrophobic peptides, all three proteins differ extensively in their fine structure.
(19) Failure to meet these deadlines, and others listed in the judgement, face a daily fine of 150,000 reais.
(20) Nuclear DNA distribution in fine-needle specimens from 112 breast carcinomas and 45 prostatic tumours was studied.
Refinement
Definition:
(n.) The act of refining, or the state of being refined; as, the refinement or metals; refinement of ideas.
(n.) That which is refined, elaborated, or polished to excess; an affected subtilty; as, refinements of logic.
Example Sentences:
(1) The patients had a high AP, consumed more alcohol, were more well-fed, older and consumed more refined carbohydrates per 1 kg bw and less cholesterol and vegetable protein.
(2) After restrained least-squares refinement of the enzyme-substrate complex with the riboflavin omitted from the model, additional electron density appeared near the pyrophosphate, which indicated the presence of an ADPR molecule in the FAD binding site of PHBH.
(3) Well-refined x-ray structures of the liganded forms of the wild-type and a mutant protein isolated from a strain defective in chemotaxis but fully competent in transport have provided a molecular view of the sugar-binding site and of a site for interacting with the Trg transmembrane signal transducer.
(4) To meet these prerequisites we have introduced some technical refinements: (1) computer-controlled rectilinear translations of the target in combination with different angular positions of the source and (2) computer-controlled rotations of the target around a vertical axis in combination with different angular positions of the source.
(5) Percutaneous transhepatic biliary drainage (PTBD) was conceptualized more than 35 years ago, but its clinical application only flourished in the past 10 years after a number of technical refinements.
(6) In 1984 the press-fit condylar knee was first introduced and was intended to provide a condylar knee system primarily for posterior cruciate retention that addressed refinements in metallurgy, prosthetic geometry and sizing, cementless fixation, inventory management, and instrumentation.
(7) Obviously, the sheer number of lasers being used both clinically and experimentally indicates a great potential for further advancement and refinement in technique and surgical outcomes.
(8) Phases from x-ray structure factors (R = 0.43) computed from this model were then used in the calculation of another electron density map against which the model was further refined.
(9) Staging classifications are being refined to reflect increasing knowledge of important prognostic indicators, e.g., absence or presence of lymph node involvement, pattern of lymph node involvement, and absence or presence of visceral disease.
(10) The ordered aspect of the genetic code table makes this result a plausible starting point for studies of the origin and evolution of the genetic code: these could include, besides a more refined optimization principle at the logical level, some effects more directly related to the physico-chemical context, and the construction of realistic models incorporating both aspects.
(11) The structure of Mn(III) superoxide dismutase (Mn(III)SOD) from Thermus thermophilus, a tetramer of chains 203 residues in length, has been refined by restrained least-squares methods.
(12) Based on the refined atomic coordinates of the tRNAphe in the orthorhombic crystal, on the recent advances in the distance dependence of the ring-current magnetic field effects and on the adopted values for the isolated hydrogen-bonded NH resonances, a computed spectrum consisting of 23 protons was constructed.
(13) It can be used as a simple screening procedure to help determine which of many possible anthelmintic control strategies should be selected for more detailed examination in the field, and it provides a theoretical framework within which ideas concerning the epidemiology of parasitic gastroenteritis can be assessed and refined.
(14) The advances in lid and orbital surgery are due to the improvements made in diagnostic equipment and to technical refinements.
(15) The group’s refining business performed better than expected, more than doubling profit to $2.2bn from $1bn.
(16) They also suggest that both the migration of cortical neurons on glia and the refinement of the mapping between the peripheral whisker field and its cortical representation may depend upon the distribution of substrate adhesion molecules.
(17) Thus the present study gives support for a protective effect associated with a fiber-rich or vegetable-rich diet, while it indicates that frequent consumption of refined starchy foods, eggs and fat-rich foods such as cheese and red meat is a risk factor for colo-rectal cancer.
(18) Synthesis and discussion is focused on five major areas in which gerontological continuity and change are evidenced: 1) transformation of basic themes over time; 2) gerontology's identity crisis; 3) the social ideology of gerontology; 4) evolution and refinement of gerontological ideas and methods; and 5) temporal frameworks.
(19) The course content and format were refined after 11 pharmacists completed a pilot program.
(20) This has led to important advances in our understanding of the mechanism of axonal guidance, the physiology of neurotrophic factors and the establishment and refinement of neural connections.