(superl.) Fixed; hence, closely compressed; compact; substantial; hard; solid; -- applied to the matter of bodies; as, firm flesh; firm muscles, firm wood.
(superl.) Not easily excited or disturbed; unchanging in purpose; fixed; steady; constant; stable; unshaken; not easily changed in feelings or will; strong; as, a firm believer; a firm friend; a firm adherent.
(superl.) Solid; -- opposed to fluid; as, firm land.
(superl.) Indicating firmness; as, a firm tread; a firm countenance.
(a.) The name, title, or style, under which a company transacts business; a partnership of two or more persons; a commercial house; as, the firm of Hope & Co.
(a.) To fix; to settle; to confirm; to establish.
(a.) To fix or direct with firmness.
Example Sentences:
(1) Villagers, including one man who has been left disabled and the relatives of six men who were killed, are suing ABG in the UK high court, represented by British law firm Leigh Day, alleging that Tanzanian police officers shot unarmed locals.
(2) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(3) Video games specialist Game was teetering on the brink of collapse on Friday after a rescue deal put forward by private equity firm OpCapita appeared to have been given the cold shoulder by lenders who are owed more than £100m.
(4) One is that the issue of whether the World Cup should go ahead in Russia and Qatar still firmly remains on the table.
(5) Neil Blessitt Bristol • We need to establish what the legal position is with regard to the establishment by the government of a private company co-owned by the Department of Health and the French firm Sopra Steria.
(6) Particular attention has been paid to diabetes mellitus and chronic pancreatitis, but a firm conclusion cannot be drawn.
(7) Pupils who disrupt the learning of their classmates are dealt with firmly and, in many cases, a short suspension is an effective way of nipping bad behaviour in the bud."
(8) Cloning of the A-T allele(s) will assist in the early or prenatal diagnosis of A-T and provide a firm basis for determining who, in the general population, carries this gene and is therefore at a high risk of cancer.
(9) We are firmly opposed to that," an unidentified spokesman from the ministry of industry and information technology told the state news agency, Xinhua.
(10) Officers arrested her last month during the protest against oil drilling by the energy firm Cuadrilla at Balcombe in West Sussex – a demonstration Lucas has attended several times.
(11) "At the moment there are about 1,600 criminal justice firms, and they all have a contract with the lord chancellor.
(12) VAT increases don't just hit the poor more than the rich, they also hit small firms, threaten retail jobs and, by boosting inflation, could also lead to higher interest rates."
(13) Her story is an incredible tale of triumph over tragedy: a tormented childhood during China's Cultural Revolution, detention and forced exile after exposing female infanticide – then glittering success as the head of a major US technology firm.
(14) We firmly believe that a systematic approach to the 12-lead ECG can provide information that can diagnose the difference between ventricular and supraventricular tachycardia, and in many instances diagnose the mechanism and site of origin of the supraventricular tachycardia.
(15) Terry Waite Chair, Benedict Birnberg Deputy chair, Antonio Ferrara CEO The Prisons Video Trust • If I want to build a bridge, I call in a firm of civil engineers who specialise in bridge-building.
(16) The court hearing – in a case of the kind likely to be heard in secret if the government's justice and security bill is passed – was requested by the law firm Leigh Day and the legal charity Reprieve, acting for Serdar Mohammed, tortured by the Afghan security services after being transferred to their custody by UK forces.
(17) Doubts about Hinkley Point have deepened after a detailed report by HSBC’s energy analysts described eight key challenges to the project, which will be built by the state-backed French firm EDF and be part-financed by investment from China .
(18) China's relations with the NTC were strained last week when it emerged Chinese arms firms had talked to Muammar Gaddafi's representatives about weapons sales .
(19) It may not point to independence – nor, given that large swaths of Wales remain firmly dominated by Labour, mean any huge advance for Plaid Cymru.
(20) In order to identify these anchorage structures, the non-DNA materials that remain firmly bound to chromosomal DNA under conditions that disintegrate the high salt-stable architecture of nuclei were investigated.
Tight
Definition:
() of Tie
() p. p. of Tie.
(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.