(a.) Preceding all others of a series or kind; the ordinal of one; earliest; as, the first day of a month; the first year of a reign.
(a.) Foremost; in front of, or in advance of, all others.
(a.) Most eminent or exalted; most excellent; chief; highest; as, Demosthenes was the first orator of Greece.
(adv.) Before any other person or thing in time, space, rank, etc.; -- much used in composition with adjectives and participles.
(n.) The upper part of a duet, trio, etc., either vocal or instrumental; -- so called because it generally expresses the air, and has a preeminence in the combined effect.
Example Sentences:
(1) First results let us assume that clinically silent TIAs also (in analogy to clinically silent brain infarctions) could be detected and located.
(2) Here we report that sperm from psr males fertilizes eggs, but that the paternal chromosomes are subsequently condensed into a chromatin mass before the first mitotic division of the egg and do not participate in further divisions.
(3) However, when first trimester specimens were analyzed, the direct-product measurements were significantly larger than the corresponding 3H2O assay results.
(4) In Patient 2 they were at first paroxysmal and unformed, with more prolonged metamorphopsia; later there appeared to be palinoptic formed images, possibly postictal in nature.
(5) Van Persie's knee injury meant that Mata could work in tandem with the delightfully nimble Kagawa, starting for the first time since 22 January.
(6) These studies led to the following conclusions: (a) all the prominent NHP which remain bound to DNA are also present in somewhat similar proportions in the saline-EDTA, Tris, and 0.35 M NaCl washes of nuclei; (b) a protein comigrating with actin is prominent in the first saline-EDTA wash of nuclei, but present as only a minor band in the subsequent washes and on washed chromatin; (c) the presence of nuclear matrix proteins in all the nuclear washes and cytosol indicates that these proteins are distributed throughout the cell; (d) a histone-binding protein (J2) analogous to the HMG1 protein of K. V. Shooter, G.H.
(7) The issue of the Schizophrenia Bulletin is devoted to articles representing this full range of conceptual and empirical work on first-episode psychosis.
(8) We conclude that first-transit and blood-pool techniques are equally accurate methods for determining EF when the time-activity method of analysis is employed.
(9) Oculomotor paresis with cyclic spasms is a rare syndrome, usually noticeable at birth or developing during the first year of life.
(10) In early 2000, during the first months of Vladimir Putin’s presidency, Babitsky was kidnapped by Russian forces and disappeared for many weeks.
(11) The Frenchman’s 65th-minute goal was a fifth for United and redemptive after he conceded the penalty from which CSKA Moscow took a first-half lead.
(12) The intrauterine mean active pressure (MAP) in the nulliparous group was 1.51 kPa (SD 0.45) in the first stage and 2.71 kPa (SD 0.77) in the second stage.
(13) For the first time it was organized on the basis of population.
(14) Immunocompetence was also evident when the cells from thymectomized donors were first incubated with thymus extract for 1 hr and subsequently tested for reactivity.
(15) gamma-Aminobutyric acid (GABA) and glutamate release from the treated side was higher than the control value during the first 2-3 h, a result indicating an important role of glial cells in the inactivation of released transmitter.
(16) The results of the evaluation confirm that most problems seen by first level medical personnel in developing countries are simple, repetitive, and treatable at home or by a paramedical worker with a few safe, essential drugs, thus avoiding unnecessary visits to a doctor.
(17) Complementarity determining regions (CDR) are conserved to different extents, with the first CDR region in all family members being among the most conserved segments of the molecule.
(18) Despite of the increasing diagnostic importance of the direct determination of the parathormone which is at first available only in special institutions in these cases methodical problems play a less important part than the still not infrequent appearing misunderstanding of the adequate basic disease.
(19) The present findings indicate that the deafferented [or isolated] hypothalamus remains neuronally isolated from the environment if the operation is carried out later than the end of the first week of life.
(20) Amino acid sequence analysis showed that both peaks had identical N-terminal sequences through the first 28 residues.
Lead
Definition:
(n.) An open way in an ice field.
(n.) A lode.
(n.) One of the elements, a heavy, pliable, inelastic metal, having a bright, bluish color, but easily tarnished. It is both malleable and ductile, though with little tenacity, and is used for tubes, sheets, bullets, etc. Its specific gravity is 11.37. It is easily fusible, forms alloys with other metals, and is an ingredient of solder and type metal. Atomic weight, 206.4. Symbol Pb (L. Plumbum). It is chiefly obtained from the mineral galena, lead sulphide.
(n.) An article made of lead or an alloy of lead
(n.) A plummet or mass of lead, used in sounding at sea.
(n.) A thin strip of type metal, used to separate lines of type in printing.
(n.) Sheets or plates of lead used as a covering for roofs; hence, pl., a roof covered with lead sheets or terne plates.
(n.) A small cylinder of black lead or plumbago, used in pencils.
(v. t.) To cover, fill, or affect with lead; as, continuous firing leads the grooves of a rifle.
(v. t.) To place leads between the lines of; as, to lead a page; leaded matter.
(v. t.) To guide or conduct with the hand, or by means of some physical contact connection; as, a father leads a child; a jockey leads a horse with a halter; a dog leads a blind man.
(v. t.) To guide or conduct in a certain course, or to a certain place or end, by making the way known; to show the way, esp. by going with or going in advance of. Hence, figuratively: To direct; to counsel; to instruct; as, to lead a traveler; to lead a pupil.
(v. t.) To conduct or direct with authority; to have direction or charge of; as, to lead an army, an exploring party, or a search; to lead a political party.
(v. t.) To go or to be in advance of; to precede; hence, to be foremost or chief among; as, the big sloop led the fleet of yachts; the Guards led the attack; Demosthenes leads the orators of all ages.
(v. t.) To draw or direct by influence, whether good or bad; to prevail on; to induce; to entice; to allure; as, to lead one to espouse a righteous cause.
(v. t.) To guide or conduct one's self in, through, or along (a certain course); hence, to proceed in the way of; to follow the path or course of; to pass; to spend. Also, to cause (one) to proceed or follow in (a certain course).
(v. t.) To begin a game, round, or trick, with; as, to lead trumps; the double five was led.
(v. i.) To guide or conduct, as by accompanying, going before, showing, influencing, directing with authority, etc.; to have precedence or preeminence; to be first or chief; -- used in most of the senses of lead, v. t.
(v. t.) To tend or reach in a certain direction, or to a certain place; as, the path leads to the mill; gambling leads to other vices.
(n.) The act of leading or conducting; guidance; direction; as, to take the lead; to be under the lead of another.
(n.) precedence; advance position; also, the measure of precedence; as, the white horse had the lead; a lead of a boat's length, or of half a second.
(n.) The act or right of playing first in a game or round; the card suit, or piece, so played; as, your partner has the lead.
(n.) The course of a rope from end to end.
(n.) The width of port opening which is uncovered by the valve, for the admission or release of steam, at the instant when the piston is at end of its stroke.
(n.) the distance of haul, as from a cutting to an embankment.
(n.) The action of a tooth, as a tooth of a wheel, in impelling another tooth or a pallet.
Example Sentences:
(1) Thirty-two patients (10 male, 22 female; age 37-82 years) undergoing maintenance haemodialysis or haemofiltration were studied by means of Holter device capable of simultaneously analysing rhythm and ST-changes in three leads.
(2) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(3) LHRH therapy leads to higher plasma LH levels and a lower FSH in response to an intravenous LHRH test.
(4) These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens.
(5) These are typically runaway processes in which global temperature rises lead to further releases of CO², which in turn brings about more global warming.
(6) Results indicated a .85 probability that Directive Guidance would be followed by Cooperation; a .67 probability that Permissiveness would lead to Noncooperation; and a .97 likelihood that Coerciveness would lead to either Noncooperation or Resistance.
(7) It would be fascinating to see if greater local government involvement in running the NHS in places such as Manchester leads over the longer term to a noticeable difference in the financial outlook.
(8) The Frenchman’s 65th-minute goal was a fifth for United and redemptive after he conceded the penalty from which CSKA Moscow took a first-half lead.
(9) Our results indicate that increasing the delay for more than 8 days following irradiation and TCD syngeneic BMT leads to a rapid loss of the ability to achieve alloengraftment by non-TCD allogeneic bone marrow.
(10) report the complications registered, in particular: lead's displacing 6.2%, run away 0.7%, marked hyperthermya 0.0%, haemorrage 0.4%, wound dehiscence 0.3%, asectic necrosis by decubitus 5%, septic necrosis 0.3%, perforation of the heart 0.2%, pulmonary embolism 0.1%.
(11) The availability and success of changes in reproductive technology should lead to a reappraisal of the indications for hysterectomy, especially in young women.
(12) Photoirradiation of F1 in the presence of the analog leads to inactivation depending linearly on the incorporation of label.
(13) In patients with coronary artery disease, electrocardiographic signs of left atrial enlargement (LAE-negative P wave deflection greater than or equal to 1 mm2 in lead V1) are associated with increased left ventricular end diastolic pressure (LVEDP).
(14) The new Somali government has enthusiastically embraced the new deal and created a taskforce, bringing together the government, lead donors (the US, UK, EU, Norway and Denmark), the World Bank and civil society.
(15) Suggested is a carefully prepared system of cycling videocassettes, to effect the dissemination of current medical information from leading medical centers to medical and paramedical people in the "bush".
(16) Mitonafide is the lead compound of a new series of antitumor drugs, the 3-Nitronaphthalimides, which have shown antineoplastic activity in vitro as well as in vivo.
(17) The presently available data allow us to draw the following conclusions: 1) G proteins play a mediatory role in the transmission of the signal(s) generated upon receptor occupancy that leads to the observed cytoskeletal changes.
(18) In the case presented, overdistension of a jejunostomy catheter balloon led to intestinal obstruction and pressure necrosis (of the small bowel), with subsequent abscess formation leading to death from septicemia.
(19) This is rapidly followed by a gamut of changes leading to demyelination.
(20) In crosses between inverted repeats, a single intrachromatid reciprocal exchange leads to inversion of the sequence between the crossover sites and recovery of both genes involved in the event.