(n.) A colorless, crystalline hydrocarbon, C13H10 having a beautiful violet fluorescence; whence its name. It occurs in the higher boiling products of coal tar, and is obtained artificially.
Example Sentences:
(1) In contrast to the helix-destabilizing and distortive modifications of DNA caused by ultraviolet light or N-acetoxy-2-(acetylamino)fluorene, CC-1065 increases the melting point of DNA and decreases the S1 nuclease activity.
(2) The conformation and configuration at the central nitrogen of the adduct 8-(N-fluoren-2-ylamino)-2'-deoxyguanosine 5'-monophosphate has been investigated by high-field 13C and 15N NMR spectroscopy.
(3) Recognition of damage induced by N-hydroxy-2-aminofluorene (N-OH-AF) and N-acetoxy-2-(acetylamino)fluorene (NAAAF) in both phi X174 RFI supercoiled DNA and a linear DNA fragment by purified UVRA, UVRB, and UVRC proteins was investigated.
(4) Two non-reactive fluorene-containing compounds were synthesized, and both reagents exhibited far less binding to calmodulin than did trifluoperazine.
(5) The spectroscopic characteristics of adducts derived from the covalent binding of the carcinogen 2-aminofluorene to the C8 position of deoxyguanosine [N-(deoxyguanosin-8-yl)-2-amino-fluorene, dGuo-C8-AF], and from an adduct of similar structure formed with the synthetic polynucleotide poly(dG-dC).poly(dG-dC), were investigated.
(6) On replacement of the 5'-dimethoxytrityl blocking group on the trinucleotide phosphoramidite with an acid-stable blocking group, such as levulinate or fluoren-9-ylmethoxycarbonyl (Fmoc), this same strategy of substoichiometric couplings at codon boundaries should permit the synthesis of complex pools of oligonucleotides for the introduction, with constant efficiency, of every type of amino acid substitution at each codon across a gene segment.
(7) The high-field 1H NMR spectra of a nucleotide-carcinogen adduct formed from 2-(acetylamino)fluorene (8-(N-fluoren-2-ylacetamido)-2'-deoxyguanosine 5'-monophosphate) have been examined in aqueous solution as a function of concentration at high and low temperatures.
(8) IPS 339 [(tertiarybutylamino-3-ol-2-propyl)oximino-9-fluorene hydrochloride], a beta 2-selective antagonist, was at least 3 orders of magnitude more potent in inhibiting the binding of [3H]DHA than the beta 1-antagonist, atenolol.
(9) Human serum albumin fluorescence quenching by fluorene-9-spiro-oxazolidinedione has been analyzed as a function of temperature.
(10) 1-(Fluoren-2-yl)-2-propen-1-one (vinyl fluorenyl ketone, VFK) was shown to be a potent and irreversible inactivator of NAT II activities.
(11) One-carbonyl quinonoid compounds, fluorenone (fluoren-9-one), anthrone, and their derivatives are introduced into spinach photosystem (PS) I reaction centers in place of the intrinsic secondary electron acceptor phylloquinone (= vitamin K1).
(12) The derivatives of 3 had more potent antagonistic activity than those of 2 and the order of potency of 3 was: chloriminodibenzyl greater than chlordibenzocycloheptene greater than iminodibenzyl greater than iminostilbene greater than fluorene.
(13) The 9-(aminomethyl)fluorenes also exhibited weak D2 binding; however, 2,5,6-trihydroxy-9H-fluorene-9-methanamine (4b) exhibited D1 binding comparable to apomorphine.
(14) This medicinal preparation of fluorenal permits reduce its concentration and the number of instillations.
(15) The polycyclic carcinogens tested (e.g., 2-nitroso-fluorene) revert 3052 by deleting a [unk] doublet from the DNA sequence [unk], which is close to the 3052 site.
(16) Different ways of purification of the fluorene modified DNA samples were checked in order ot obtain a nucleic acid free from all noncovalently bound fluorene residues.
(17) The two chains (A- and B-chains) were synthesized separately by the solid-phase method using fluoren-9-ylmethoxycarbonyl (Fmoc) group as a protecting group for alpha-amino group.
(18) Concerning the feeding schedule of 2,7-bis(acetamido)fluorene alone, the intermittent one-week feeding of the carcinogen with 3-week intervals decreased the average number of hepatic nodules as compared with the continuous feeding of the carcinogen.
(19) Methods and their applications are described for the determination of fluorene in fish, sediment, and plants.
(20) Purified DNA from the liver of rats, mice, rabbits, and guinea pigs, from guinea pig lymph nodes, from hyperplastic nodules induced in rat liver by feeding with 2-(acetylamino)fluorene, and from Escherichia coli cells was made apurinic by reaction with diphenylamine.
Fluorite
Definition:
(n.) Calcium fluoride, a mineral of many different colors, white, yellow, purple, green, red, etc., often very beautiful, crystallizing commonly in cubes with perfect octahedral cleavage; also massive. It is used as a flux. Some varieties are used for ornamental vessels. Also called fluor spar, or simply fluor.
Example Sentences:
(1) Animal experiments showed that calcium fluorite can induce only a foreign body reaction in the lungs; the fibrous nodular lesions induced by the fluorite mine dust are due mainly to its silica component.
(2) On the basis of the investigations a complex filter made of silver plated minerals--dolomite and fluorite--has been developed.
(3) NMR analysis showed FAP or FHAP as a reaction product of fluoride uptake under all conditions, regardless of whether CaF2 was formed, unambiguously demonstrating fluorite as an additive rather than substitute form of F reactivity.
(4) The occurrence of fluorite in mysid statoliths confirms the earlier interpretations based on insufficient documentation.
(5) It was also demonstrated that having engulfed calcium fluorite, silica, or fluorite mine mixed dust, PAMs release an elastase-active substance.
(6) Use of acetyl hypo[18F]fluorite gives [18F]-4 in 60 min in 20-42% radiochemical yield.
(7) The environmental survey included measurements of the dust respirable fraction and fluorite concentration in the air.
(8) The authors suggest that the emphysematous lesion seen in autopsy material of pneumoconiosis of fluorite mine workers may be caused by calcium fluorite and silica.
(9) A compact autosynthesizer was developed and used successfully for the production of 2-deoxy-2-[18F]fluoro-D-glucose [18FDG] from gaseous acetyl hypo[18F]fluorite.
(10) X-ray diffraction patterns show that the statoliths of marine mysid crustaceans are composed of fluorite, and that this mineral is also a principal phase of the gizzard plates of some tectibranch gastropods.
(11) At pH's less than 5.0 to 6.0 the solubility product of fluorite, and not that of fluorapatite, is the governing principle under the experimental conditions used.
(12) It was demonstrated that either silica or the mixed dust of a fluorite mine can stimulate pulmonary alveolar macrophages (PAMs) to release fibrogenetic factors in vitro, but calcium fluorite cannot.
(13) Furthermore, fluorite (CaF2) makes the slag more fluid.
(14) The authors investigated the influence of working conditions--with particular reference to dust and fluorite pollution--on the epidemiology of chronic bronchitis in 197 subjects working in a fertilizer producing plant in Krakow (Poland).
(15) The pathogenicity of mixed dust from a fluorite mine was studied by animal experiments and in vitro tests.
(16) The unit has been similarly configured and programmed to synthesize 2-deoxy-2-[18F]fluoro-D-mannose (48% EOB), 3-(2'-[18F]fluoroethyl)spiperone (29% EOB), and [18F]fluoroacetate (66% EOB) from aqueous [18F]-fluoride ion, and 2-[18F]FDG from gaseous acetyl hypo[18F]fluorite (20% EOB).
(17) All sample fumes from low hydrogen welding in several atmospheric conditions contained fluorite (CaF2).