(1) Neonatal alloimmune thrombocytopenic purpura (NAITP) is induced by maternal antibodies to fetal platelet alloantigens.
(2) They review the platelet antigen systems involved in NAITP and raise the problem of its present antenatal and postnatal management.
(3) This antigen is considered to be a product of an allele of the Yuk gene, another allele of which codes for Yuka which was involved in 2 cases of NAITP.
(4) anti-HLA-A24+B51 and anti-HLA-Bw61+Cw3, respectively, were detected in the mother's sera, which reacted to each patient's lymphocytes and were presumed to have been contribute to NAITP.
(5) Antibodies to the platelet HPA-1a antigen can elicit in the newborn a condition known as neonatal alloimmune thrombocytopenic purpura (NAITP).
(6) The case report emphasises that in patients with NAITP intracranial haemorrhage may occur in utero and during the perinatal period as well.
(7) Furthermore, in a review from the currently available literature the following items will be discussed: 1) human platelet antigens involved in NAITP, 2) clinical aspects and prognosis of NAITP, 3) immunological diagnosis of NAITP, and 4) prevention and treatment of the disease.
(8) We propose further study to determine if this is specific for the antepartum diagnosis of NAITP.
(9) Here reported are two cases with neonatal alloimmune thrombocytopenia (NAITP).
(10) However, the strongest association both in mothers of NAITP patients and in PTP patients was observed with the supertypic DRw52 antigen.
(11) On the other hand, some NAITP cases may have been overlooked because of their mildness.
(12) The only mother who was delivered of a child with clinical NAITP was the woman with anti-Zwa(PIA1) in serum.
(13) Sensitive assays of maternal platelet alloantibody are now available, but they lack specificity for NAITP affecting the current gestation.
(14) The authors report a case of two siblings who developed a neonatal alloimmune thrombocytopenia (NAITP) due to Bak-System incompatibility.
(15) We report a new platelet antigen (Yukb) involved in a case of neonatal alloimmune thrombocytopenia (NAITP).
(16) We demonstrate the sonographic and computer-tomographic findings in a newborn with neonatal alloimmune thrombocytopenia (NAITP).
(17) The strong association between HLA-DR3 and Zwa alloimmunization in Zwa-negative mothers, resulting in the production of anti-Zwa antibodies and ultimately in neonatal alloimmune thrombocytopenic purpura (NAITP) in the newborn, could be confirmed.
(18) We reviewed 58 literature reports of neonatal alloimmune thrombocytopenic purpura (NAITP).