(v. t.) To lap or lay in plaits or folds; to lay one part over another part of; to double; as, to fold cloth; to fold a letter.
(v. t.) To double or lay together, as the arms or the hands; as, he folds his arms in despair.
(v. t.) To inclose within folds or plaitings; to envelop; to infold; to clasp; to embrace.
(v. t.) To cover or wrap up; to conceal.
(v. i.) To become folded, plaited, or doubled; to close over another of the same kind; to double together; as, the leaves of the door fold.
(v.) A doubling,esp. of any flexible substance; a part laid over on another part; a plait; a plication.
(v.) Times or repetitions; -- used with numerals, chiefly in composition, to denote multiplication or increase in a geometrical ratio, the doubling, tripling, etc., of anything; as, fourfold, four times, increased in a quadruple ratio, multiplied by four.
(v.) That which is folded together, or which infolds or envelops; embrace.
(n.) An inclosure for sheep; a sheep pen.
(n.) A flock of sheep; figuratively, the Church or a church; as, Christ's fold.
(n.) A boundary; a limit.
(v. t.) To confine in a fold, as sheep.
(v. i.) To confine sheep in a fold.
Example Sentences:
(1) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(2) 5-Azacytidine (I) stability was increased approximately 10-fold over its stability in water or lactated Ringer injection by the addition of excess sodium bisulfite and the maintenance of pH approximately 2.5.
(3) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(4) The enzyme was solubilized by Triton X-100 and purified approximately 480-fold by gel filtration and affinity chromatography on alanine methyl ketone-AH-Sepharose 4B.
(5) The DNA untwisting enzyme has been purified approximately 300-fold from rat liver nuclei.
(6) IP3 increased 1.7-fold and IP2 1.6-fold after 20 and 40 s, respectively.
(7) Short incubations with heparin (5 min) caused a release of the enzyme into the media, while longer incubations caused a 2-8-fold increase in net lipoprotein lipase secretion which was maximal after 2-16 h depending on cell type, and persisted for 24 h. The effect of heparin was dose-dependent and specific (it was not duplicated by other glycosaminoglycans).
(8) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(9) Epicanthal folds were present in 46%, mongoloid slanting of the lids in 72% of cases.
(10) The estimated DNA compaction ratio (approximately 3-fold) is consistent with a significant degree of nucleosome unfolding in the hyperstimulated BR genes.
(11) Two hours after refeeding rats fasted for 48 h, ODC activity increased 40-fold in mucosa from the intact jejunum and 4-fold in the mucosa of the bypassed segments.
(12) Transfection of the treated DNA into SOS-induced spheroplasts results in an increase in mutagenesis as great as 50-fold.
(13) ACh released from the vesicular fraction was about 100-fold more than could be accounted for by miniature end-plate potentials; possible causes of this overestimate are discussed.
(14) In strains completely deleted for galR, the gene which encodes the Gal repressor, the operon is derepressed by only 10-fold without an inducer.
(15) The amount of water, creatinine, electrolytes, proteins, and enzymes were higher during the day (up to three fold, p always less than 0.05), while equal amounts of amino acids were excreted in the day and the night period.
(16) TNBS reacts to an extremely small extend with hemoglobin over the concentration range 0.4 to 4 mM whereas FDNB reacts with hemoglobin to a very large extent (50 fold more than TNBS).
(17) Rates of PC in vitro metabolism by liver and kidney cytosolic cysteine conjugate beta-lyases (beta-lyases) were similar, but metabolism by renal mitochondrial beta-lyase occurred at a 3-fold higher rate than the rate obtained with hepatic mitochondrial beta-lyase.
(18) Dietary factors affect intestinal P450s markedly--iron restriction rapidly decreased intestinal P450 to beneath detectable values; selenium deficiency acted similarly but was less effective; Brussels sprouts increased intestinal AHH activity 9.8-fold, ECOD activity 3.2-fold, and P450 1.9-fold; fried meat and dietary fat significantly increased intestinal EROD activity; a vitamin A-deficient diet increased, and a vitamin A-rich diet decreased intestinal P450 activities; and excess cholesterol in the diet increased intestinal P450 activity.
(19) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(20) The gene, which is located at chromosome XIII, is transcribed as a mRNA of about 2.7 kilobases, and the amount of message has been found to increase 3- to 4-fold during the culture.
Reprehensible
Definition:
(a.) Worthy of reprehension; culpable; censurable; blamable.
Example Sentences:
(1) The fact that the security service was in possession of and retained the copy tape until the early summer of 1985 and did not bring it to the attention of Mr Stalker is wholly reprehensible,” he wrote.
(2) Details of the episode in October 2011 surfaced publicly last summer when the Bank's executive director for markets, Paul Fisher, told MPs that claims about the "thoroughly reprehensible" allegations had been referred to the regulator.
(3) The authors urge that patients suffering from from facial paralysis should be referred to O.-R.-L. departments right from the start and not when all other methods of treatment have been tried, often with reprehensible empiricism, and found unsuccessful.
(4) And let me say that I find much of the media utterly reprehensible and in need of a new regulator that it can probably get away with setting up itself … Newspapers: Ever so 'umble, sir.
(5) By far the most shocking thing was that McBride was a civil servant at the time, acting in a highly political and thoroughly reprehensible manner.
(6) The dumping of excrement on the statue was “reprehensible and regrettable” and an investigation was under way, the university said in a statement last week.
(7) If you care about people on low incomes, if you care about refugees, if you care about tackling climate change, if you care about the fact that the NHS is chronically underfunded, about divisions, lack of opportunity, failure to maximise potential in the north, then backing a leadership which is going to fail to stand up for any of those causes is utterly reprehensible.
(8) Describing the award as “morally reprehensible” and calling for it to be rescinded, the petition has gathered more than 500 staff signatures.
(9) "It's reprehensible, and there's no room for grey areas," Miliband said.
(10) Like phone hacking or MPs' fiddled expenses, this is an issue that only needs to be described to seem reprehensible.
(11) The sectarian conflict responsible for much of the war's reprehensible human cost was caused in part by the occupying forces' division of the country's political system along sectarian lines.
(12) But corporations, which thrive on their sense of power and control, hate nothing more than having to say sorry unless they are forced to do so because they are squirming on the end of a hook for doing something particularly reprehensible.
(13) Jean Ping, head of the commission of the African Union continental grouping, said he was "deeply concerned by the reprehensible acts currently being perpetrated by some elements of the Malian army".
(14) Cable has alleged that his close friend leaked the ICM polling to the Guardian, describing it as "utterly reprehensible" and "totally unacceptable", and adding that there was no leadership issue.
(15) Facebook Twitter Pinterest Sean Spicer on Assad regime: ‘Even Hitler didn’t use chemical weapons’ Despite one more ineffective attempt to make things right (“Any attack on innocent people is reprehensible and inexcusable.”) Spicer’s combination of callousness and historical amnesia inspired a range of critics – from Democratic House leader Nancy Pelosi to Steven Goldstein, director of the Anne Frank Center – to demand that he be fired.
(16) Turkey had last month accused Britain of a “reprehensible” delay in informing the Turkish authorities over the departure to its territory of the three teenage girls.
(17) And many, many other Americans feel the same way.” White House press secretary Josh Earnest called Trump’s remarks “incendiary” and “morally reprehensible”, adding: “What Donald Trump said yesterday disqualifies him from serving as president.” Facebook Twitter Pinterest Trump’s anti-Muslim comments ‘disqualify him for president’, says White House .
(18) Bailey said it was "reprehensible" of George Osborne, the chancellor, to refuse to publicly debate the potential threats and refer to any deal as no more than "a commercial matter between the companies".
(19) Photograph: Paul McErlane Handing down his judgment in McCauley’s appeal last September, Sir Declan Morgan, the lord chief justice of Northern Ireland, was in agreement with Sampson: “The failure of the security service to disclose the tape to Mr Stalker and to provide it to the prosecution was reprehensible.” Furthermore, the deputy head of special branch had initially misled the director of public prosecutions by leading him to believe that there was no listening device in the hayshed.
(20) The events which took place on 17 and 18 February in Malakal Protection of Civilians site are utterly reprehensible,” said Eugene Owusu, the UN’s humanitarian coordinator for South Sudan.