(n.) A univalent radical, H.C:O, regarded as the essential residue of formic acid and aldehyde.
(n.) Formerly, the radical methyl, CH3.
Example Sentences:
(1) Preincubation of human neutrophils with recombinant tumor necrosis factor alpha has previously been shown by us to enhance superoxide production of neutrophils in response to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine, and the phorbol ester, phorbol myristate acetate.
(2) Addition of MoAb 60.3 to normal neutrophils produced dose-dependent inhibition of neutrophil aggregation in response to phorbol myristate acetate, zymosan-activated plasma, and N-formyl-methionylleucylphenylalanine.
(3) In the intact neutrophil, this enzyme can be activated by increases in cytosolic calcium, protein kinase C, and unsaturated fatty acids such as arachidonic acid, all of which are produced on stimulation by chemotactic peptides like N-formyl-methionyl-leucyl-phenylalanine.
(4) Forphenicinol, L-2-(4-formyl-3-hydroxymethylphenyl) glycine, is a newly discovered low molecular weight immunomodifier.
(5) Pre-treatment of human neutrophils with myelin basic protein selectively inhibits the formyl-peptide-induced chemotaxis, without affecting chemotaxis evoked by casein and activated serum.
(6) After 5 min of binding, [3H]-N-formyl-met-leu-phe cosedimented with the Golgi marker enzymes when cytoplasts were fractionated on sucrose density gradients after N2 cavitation.
(7) Key intermediate of the synthesis was 2-formyl-estradiol (2) which was prepared in quantitative yield through reaction of the phenoxymagnesium bromide of estradiol with formaldehyde in the presence of HMPA.
(8) However N-Formyl-Methionyl-Leucyl-Phenylalanine (FMLP) stimulated chemotaxis of granulocytes, normal before therapy, was significantly impaired as early at d 8 and severely inhibited at d 36 (p less than 0.001).
(9) Our experiments are consistent with a translation mechanism using dissociated ribosomes at the 5' end of the mRNA in a reaction that is only weakly dependent on formylation at this initiation step; the ribosomes then travel along the messenger and can reinitiate after the intracistronic barrier without dissociation.
(10) The adherence of chromium 51-labeled neutrophils from patients with diabetes in the basal state and after incubation with phorbol myristate acetate (PMA) but not N-formyl-methionyl-leucyl-phenylalanine (FMLP) was decreased significantly.
(11) The results of kinetic studies support the concept that carbamyl phosphate is an analog of the putative intermediate of the formyltetrahydrofolate synthetase reaction, formyl phosphate.
(12) Purpactin A was deduced to be 3-1'-acetoxy-11-hydroxy-4-methoxy-9-methyl-3'-methylbutyl-5H, 7H-dibenzo[b,g]-1,5-dioxocin-5-one, purpactin B was 5-1''-acetoxy-6'-hydroxymethyl-4-methoxy-4'-methyl-3''-methylbutyl-spiro [benzofuran-2,1'-cyclohexa-3',5'-diene]-2',3(2H)-dione and purpactin C was 5-1''-acetoxy-6'-formyl-4-methoxy-4'-methyl-3''-methylbutyl-spiro [benzofuran-2,1'-cyclohexa-3',5'-diene]-2',3(2H)-dione.
(13) Granulocytic LDCL has been studied in granulocyte exposure to zymosan, zymosan-activated serum, phorbol-myristate acetate, and FMLP (formyl-L-methionyl-leucyl-phenylalanine) synthetic tripeptide.
(14) At low drug:DNA ratios (0.5), distamycin A binds in two orientations within the five central A-T base pairs and has a preference (2.2:1) for binding with the formyl end directed toward the 5' side of the A-rich strand.
(15) Incubation of human PMN with influenza A virus in vitro for 30 minutes significantly decreased PMN migration under agarose in response to N-formyl-methionyl-leucyl-phenylalanine (FMLP) or zymosan-activated serum.
(16) Over a wide range of concentrations (10(-7)-10(-15) M) rhuTNF alpha of two different sources failed to elicit chemotactic responses in PMN or MO, whereas strong PMN and MO chemotactic activity could be detected using the tripeptide N-formyl-methionyl-leucyl-phenylalanine (FMLP).
(17) Leukocyte and platelet aggregation stimulated with formyl-methionyl-leucyl-phenylalanine (FMLP) was measured in 32 patients with cerebral ischemia and in 15 controls, using a whole blood aggregometer.
(18) When neutrophils were stimulated with formyl-met-leu-phe, there was a further increase in platelet cyclic GMP.
(19) PMA, a specific granule secretagogue, increases affinity labeling of formyl peptide receptors on the neutrophil surface by 100%, and on d-HL-60, which lack specific granule markers, by 20%.
(20) DCFH-DA, granulocytes and stimuli (phorbol myristate acetate, n-formyl-methionyl-leucylphenylalanine, concanavalin A) were added to microtiter plates and after incubation at 37 degrees C, the development of fluorescence intensity was read in a fluorescence concentration analyzer (FCA, Baxter).
Radical
Definition:
(a.) Of or pertaining to the root; proceeding directly from the root.
(a.) Hence: Of or pertaining to the root or origin; reaching to the center, to the foundation, to the ultimate sources, to the principles, or the like; original; fundamental; thorough-going; unsparing; extreme; as, radical evils; radical reform; a radical party.
(a.) Belonging to, or proceeding from, the root of a plant; as, radical tubers or hairs.
(a.) Proceeding from a rootlike stem, or one which does not rise above the ground; as, the radical leaves of the dandelion and the sidesaddle flower.
(a.) Relating, or belonging, to the root, or ultimate source of derivation; as, a radical verbal form.
(a.) Of or pertaining to a radix or root; as, a radical quantity; a radical sign. See below.
(n.) A primitive word; a radix, root, or simple, underived, uncompounded word; an etymon.
(n.) A primitive letter; a letter that belongs to the radix.
(n.) One who advocates radical changes in government or social institutions, especially such changes as are intended to level class inequalities; -- opposed to conservative.
(n.) A characteristic, essential, and fundamental constituent of any compound; hence, sometimes, an atom.
(n.) Specifically, a group of two or more atoms, not completely saturated, which are so linked that their union implies certain properties, and are conveniently regarded as playing the part of a single atom; a residue; -- called also a compound radical. Cf. Residue.
(n.) A radical quantity. See under Radical, a.
(a.) A radical vessel. See under Radical, a.
Example Sentences:
(1) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(2) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(3) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
(4) The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of O2 radicals and an inhibitor of xanthine oxidase.
(5) Flow cytometric DNA analysis was performed on both fresh and on paraffin embedded samples obtained by gastroscopic biopsies in 5 patients with histologically normal gastric mucosa (20 specimens) and by radical gastrectomies in 9 cases of human gastric cancer (36 specimens).
(7) Residual cancer was found in the radical prostatectomy specimen in 11 of the 29 stage-A1 patients (38%) and in 66 of the 86 stage-A2 patients (77%).
(8) This may be due to DMSO's ability to scavenge free radicals.
(9) A more radical surgery is recommended but with the limitation that the operative method must be adapted to the operative finding.
(10) The present study explored the possibility that SOD-mimics such as desferrioxamine-Mn(III) chelate [DF-Mn] or cyclic nitroxide stable free radicals could protect from O2-.-independent damage.
(11) Treatment modalities included: partial temporal bone resection, subtotal temporal bone resection, total temporal bone resection, radical mastoidectomy followed by radiation therapy, radiation therapy alone, and chemotherapy.
(12) Leaders of Tory local government are preparing radical proposals for minimum 10% cuts in public spending in the search for savings.
(13) Plays like The Workhouse Donkey (1963) and Armstrong's Last Goodnight (1964) were staged in major theatres, but as the decade progressed so his identification with the increasingly radical climate of the times began to lead away from the mainstream theatre.
(14) 78% of the recurrences were seen two years postoperatively and 27% were asymptomatic; 10% underwent radical operation, 27% palliative operation and 63% conservative treatment.
(15) The kinetics of bimolecular decay of alpha-tocopheroxyl free radicals (T) was studied by ESR mainly in ethanol and heptanol solvents.
(16) While the correlations between speed and accuracy reversed over time, the abnormal vision group began and ended at the most extreme levels, having undergone a significantly more radical shift in this regard.
(17) NPR reported that investigators have not found telltale signs associated with Islamist radicalization , such as a change in mosques or abrupt shifts in behavior or family associations.
(18) The second triplet, which was stable in the dark at 4.2 K following illumination, was assigned to the radical pair Donor+I-.
(19) It may be due to relative nonreactivity of ascorbic acid free radical that free radical chain reactions, found commonly in radical chemistry, do not occur in the scavenging reaction by ascorbic acid.
(20) The free radical scavengers mannitol, thiourea, benzoate, and 4-methylmercapto-2-oxobutyrate protected either native cells exposed to H2O2 or pretreated hepatocytes exposed to H2O2 and given ferric or ferrous iron.