(a. & adv.) Four times; quadruple; as, a fourfold division.
(n.) Four times as many or as much.
(v. t.) To make four times as much or as many, as an assessment,; to quadruple.
Example Sentences:
(1) The difference in sensitivity between laboratories for end-point titres (if one very sensitive method was excluded) was around fourfold for types 1 and 2, and ninefold for type 3.
(2) HTC.JZ1 cells were stimulated to secrete up to fourfold increased amounts of IL6 over 24 hours by treatment with lipopolysaccharides (LPS).
(3) The objectivity of the items was proved by fourfold examination of the same sample group.
(4) Involved and uninvolved psoriatic epidermal cells showed a fourfold decrease in the number of 12-HETE binding sites as compared with normal healthy individuals and patients with atopic dermatitis, while receptor affinity remained unchanged.
(5) 10% NNDEMT doubled the amount of PFA in the skin, increased fourfold the amount permeated across the skin, and increased the flux fivefold.
(6) Antibody response to group A rotavirus (RV), investigated in paired sera from 72 infants and young children with acute gastroenteritis caused by an RV infection, was diagnosed on the basis of a fourfold or greater rise in group A common RV IgG antibody titer.
(7) Eighty-eight percent of subjects receiving CVD 103-HgR mounted a significant (greater than fourfold) rise in Inaba vibriocidal titre while 68% did so for the heterologous Ogawa serotype.
(8) Paired sera from 20 humans with eastern equine encephalitis (EEE) virus infections and from 17 humans with western equine encephalitis (WEE) virus infections, all with previously demonstrated fourfold or greater rises or falls in hemagglutination-inhibiting, complement-fixing, or neutralizing antibody titers, were tested for immunoglobulin M (IgM) and IgG antibodies by an enzyme immunoassay.
(9) The Ig levels were within the normal range in patients with malignant astrocytoma and glioblastoma multiforme, whereas a three- and fourfold increase in the IgM level was observed in patients with astrocytoma.
(10) However, in the presence of 4.4, 6.6 or 8.9 x 10(-3) M glucose, the same concentration of acetylcholine stimulated insulin secretion approximately fourfold.
(11) Measurements of absolute transcript abundance show that collagen mRNA is present in blastula primary mesenchyme cells at 600-700 copies per cell and at about fourfold lower amounts in other mesenchyme cells.
(12) Forskolin (10 microM) also increases TH transcription (fourfold in 15 min) by a mechanism that is not blocked by cycloheximide.
(13) The average mitochondrial volume is increased fourfold in the peripheral and midzonal regions with a commensurate decrease in the number of mitochondria per cell.
(14) Transesophageal cardioversion decreased the defibrillation threshold three- to fourfold from that of conventional transthoracic cardioversion.
(15) Such depleted monocytes exhibit a fourfold reduction in their ability to promote both internalization of T3 and production of IL-2.
(16) In other studies, the stereoisomers of tocainide were shown to have a threefold to fourfold difference in IC50 for inhibition of [3H]BTXB binding.
(17) Plasma immunoreactive TNF was increased almost fourfold in tumor-bearing nude mice compared with control nude mice.
(18) Serum gastrin levels significantly (P less than 0.01) increased threefold to fourfold during the first 1-2 months of the study when all patients ingested 40 mg of omeprazole daily.
(19) Forty-nine serum pairs with antibody to cytomegalovirus (CMV) were evaluated for rises in antibody titer (greater than or equal to fourfold) by indirect hemagglutination (IHA) and complement fixation (CF), using a freeze-thaw antigen (FT) and a glycine extract antigen (GE).
(20) Osteocalcin secretion was measured at doses as low as 0.03 nM (fourfold increase, p less than 0.05), and this activity increased further with higher doses of 1,25-(OH)2D3 to reach a plateau at 50 nM.
Quadruplicate
Definition:
(v. t.) To make fourfold; to double twice; to quadruple.
(a.) Fourfold; doubled twice; four times repeated; as, a quadruplicate ratio, or a quadruplicate proportion.
(a.) Raised to the fourth power.
Example Sentences:
(1) Three effector: target ratios (6.2:1, 25:1, and 50:1) were studied in quadruplicate using 3, 4 and 5-h incubations.
(2) The largest increases in brain weights in both sexes occurred during the first 3 years of life, when the value quadruples over that at birth, while during the subsequent 15 years the brain weight barely quintuples over that at birth.
(3) They then decreased very slowly, according to a half-life of 122 h. Although it decreases glomerular filtration, ligation of ureters 20 h before the injection quadrupled the concentration in the cortex.
(4) Official estimates suggest the number of small packages shipped into Europe more than quadrupled from 26m in 2000 to 115m two years ago.
(5) The kinetics of intravenously administered FK506 was not changed from control status two weeks after bile duct ligation, but the bioavailability of orally administered FK506 was nearly quadrupled.
(6) There is a clear benefit of quadruple drug induction treatment for retransplants and sensitized transplant candidates.
(7) This patient achieved a complete remission with cyclic quadruple chemotherapy consisting of cyclophosphamide, vincristine, procarbazine, and prednisone (COPP).
(8) Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions, indicating the presence of at least one more ubiquitin-specific processing protease in S. cerevisiae.
(9) Guinea pig alveolar macrophages were infected in quadruplicate with log10 3.8 CFU of F889 cells grown at either 25 or 41 degrees C. Counts of F889 in the alveolar macrophages infected with 25 degrees C-grown bacteria were 40% greater after 1 day of incubation (P = 2 X 10(-4)) than were counts in the alveolar macrophage suspensions inoculated with 41 degrees C-grown bacteria.
(10) Shares acquired through privatisations rose steadily on the stock markets, while the buyers of council houses found that their assets tripled or quadrupled in value in the space of five years.
(11) An inductively coupled, quadruple-tuned surface coil with a 50-ohm match at all relevant frequencies was used for both excitation and receiving.
(12) Although both stores carried the same brands and varieties of produce, all 19 cases occurred among employees of one store, which had held a celery sale coincident with the outbreak, resulting in a quadrupling of the usual volume of celery sold.
(13) during the period of one year, that triple and quadruple resistance is the most prevalent one in staphylococci - not regarded, however, the penicillin resistance which is absolutely predominant.
(14) Sequence differences in the internally quadruplicated molecules, analysed in terms of their beta-sheets, hairpins and arches, give rise to structural differences in the motifs.
(15) Furthermore, a high percentage of multiple (quadruple or more) pancreatica magna and caudae pancreatis arteries has been observed and a functional role of this peculiar arrangement is suggested.
(16) BEATING THE CHEATING Owen Gibson’s five-point plan for reform 1 Hugely increase global funding Triple it, quadruple it.
(17) Surgery consisted in quadruple coronary bypass in 1 case, triple coronary bypass in 3 cases and double coronary bypass in 6 cases using 4 autologous saphenous vein grafts, 6 autologous internal mammary artery grafts and 13 bovine internal mammary artery grafts.
(18) The price of the specially formulated milk he requires has quadrupled since last year, so his parents have had to rent out their own home and move into a much smaller, rundown one just to feed their child.
(19) The High Pay Commission revealed earlier this week that while average pay has quadrupled since 1980s, top executives have seen their remuneration rise by 4,000%.
(20) Fourteen patients (56%) had double, triple or quadruple cancers.