(1) The frequency of rare fragile sites was studied among 240 children in special schools for subnormal intelligence (IQ 52-85).
(2) A total of 13 ascertainments of folate sensitive autosomal fragile sites is observed, of which 10q23 fragility appears to be the most frequent.
(3) The fragile site at 10q25 was expressed in larger proportions of malignant than normal cells.
(4) The green fund contributions already announced (which include a $3bn pledge by the US and a $1.5bn pledge by Japan revealed during the G20 summit) “show very clearly that if we want the emerging countries and the more fragile countries to participate in this global growth, we have to ... support them,” Hollande said.
(5) Direct detection of the mutation enables the identification of fragile X negative normal transmitting males and fragile X negative carrier females.
(6) Tim Potter, managing director of support charity the Fragile X Society , adds that the challenges Tom faces in the film will give "hope and encouragement to many other families".
(7) A case of fragile-X syndrome (the Martin-Bell syndrome) in two male half-sibs from different marriages of their mother was described.
(8) Of the 188 males, 19 were found to have the fragile X syndrome, while the remaining 169 males had no recognizable cause of their mental retardation, including normal chromosomes.
(9) "The world economy remains in a deep recession and its financial system in a fragile condition," King said.
(10) A correlation between specific fragile sites and cancer breakpoints has been suggested raising the question of fragile site expression as a predisposing factor in the occurrence of cancer in some persons.
(11) Taking this into account, we derived equilibrium equations for the fragile X [fra(X)] genotype frequencies.
(12) An 18-year-old mentally retarded male with the Martin-Bell syndrome was fragile X positive.
(13) The problems Europe is having today could have a very real effect on our economy at a time when it's already fragile.
(14) The economics of the scene, she says, are "fragile".
(15) A significant relationship with heritable fragile sites was found in this study.
(16) It is associated with bony fragility, blue sclerae and abnormality of tooth dentin.
(17) The ankylosed spine may be fractured following relatively mild trauma attributable to loss of flexibility and increased fragility from osteoporosis.
(18) Apart from evidence of enhanced lysosomal and peroxisomal fragility, probably secondary to the intracellular oedema, the intracellular organelles investigated in this study were unaffected by the myopathic process.
(19) "The economy is still far too fragile to talk of a sustained recovery in the housing market, but the hope is that we are past the worst," he added.
(20) Of these new DNA markers, 5 lie in an interval defined as containing the fragile X region.
Weak
Definition:
(v. i.) Wanting physical strength.
(v. i.) Deficient in strength of body; feeble; infirm; sickly; debilitated; enfeebled; exhausted.
(v. i.) Not able to sustain a great weight, pressure, or strain; as, a weak timber; a weak rope.
(v. i.) Not firmly united or adhesive; easily broken or separated into pieces; not compact; as, a weak ship.
(v. i.) Not stiff; pliant; frail; soft; as, the weak stalk of a plant.
(v. i.) Not able to resist external force or onset; easily subdued or overcome; as, a weak barrier; as, a weak fortress.
(v. i.) Lacking force of utterance or sound; not sonorous; low; small; feeble; faint.
(v. i.) Not thoroughly or abundantly impregnated with the usual or required ingredients, or with stimulating and nourishing substances; of less than the usual strength; as, weak tea, broth, or liquor; a weak decoction or solution; a weak dose of medicine.
(v. i.) Lacking ability for an appropriate function or office; as, weak eyes; a weak stomach; a weak magistrate; a weak regiment, or army.
(v. i.) Not possessing or manifesting intellectual, logical, moral, or political strength, vigor, etc.
(v. i.) Feeble of mind; wanting discernment; lacking vigor; spiritless; as, a weak king or magistrate.
(v. i.) Resulting from, or indicating, lack of judgment, discernment, or firmness; unwise; hence, foolish.
(v. i.) Not having full confidence or conviction; not decided or confirmed; vacillating; wavering.
(v. i.) Not able to withstand temptation, urgency, persuasion, etc.; easily impressed, moved, or overcome; accessible; vulnerable; as, weak resolutions; weak virtue.
(v. i.) Wanting in power to influence or bind; as, weak ties; a weak sense of honor of duty.
(v. i.) Not having power to convince; not supported by force of reason or truth; unsustained; as, a weak argument or case.
(v. i.) Wanting in point or vigor of expression; as, a weak sentence; a weak style.
(v. i.) Not prevalent or effective, or not felt to be prevalent; not potent; feeble.
(v. i.) Lacking in elements of political strength; not wielding or having authority or energy; deficient in the resources that are essential to a ruler or nation; as, a weak monarch; a weak government or state.
(v. i.) Tending towards lower prices; as, a weak market.
(v. i.) Pertaining to, or designating, a verb which forms its preterit (imperfect) and past participle by adding to the present the suffix -ed, -d, or the variant form -t; as in the verbs abash, abashed; abate, abated; deny, denied; feel, felt. See Strong, 19 (a).
(v. i.) Pertaining to, or designating, a noun in Anglo-Saxon, etc., the stem of which ends in -n. See Strong, 19 (b).
(a.) To make or become weak; to weaken.
Example Sentences:
(1) There was a weak relation between AER and both systolic and diastolic blood pressures.
(2) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
(3) Consensual but rationally weak criteria devised to extract inferences of causality from such results confirm the generic inadequacy of epidemiology in this area, and are unable to provide definitive scientific support to the perceived mandate for public health action.
(4) The strengths and weaknesses of each technique are described in this article.
(5) In group V, five cases of Taenia saginata parasitosis were studied showing a weak positive reading.
(6) Although the longest period required for resolving weakness was three days, the MRI, the CT and the electroencephalogram revealed no significant abnormality.
(7) Her muscle weakness and hyperCKemia markedly improved by corticosteroid therapy, suggesting that the diagnosis was compatible with polymyositis (PM).
(8) It was concluded that Ta acts as a weak zeitgeber in laboratory rats and has greater effects on males compared to females.
(9) And adding to this toxic mix, was the fear that the hung parliament would lead to a weak government.
(10) Sensory loss, motor weakness, paraesthesia and a new pain were found as complications in 12, 7, 4 and 6 patients, respectively.
(11) Here's Dominic's full story: US unemployment rate drops to lowest level in six years as 288,000 jobs added Michael McKee (@mckonomy) BNP economists say jobless rate would have been 6.8% if not for drop in participation rate May 2, 2014 2.20pm BST ING's Rob Carnell is also struck by the "extraordinary weakness" of US wage growth .
(12) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(13) The weakness was treated by intensive physical rehabilitation with complete and sustained recovery in all cases.
(14) It also showed weak inhibition of the solid type of Ehrlich carcinoma and prolonged the survival period of mice inoculated with L-1210 cells.
(15) Exposure to whole cigarette smoke from reference cigarettes results in the prompt (peak activity is 6 hrs), but fairly weak (similar to 2 fold), induction of murine pulmonary microsomal monooxygenase activity.
(16) Though the concept of phase, known also as focus, is a very helpful notion, its empirical foundation is yet very weak.
(17) DL 071 IT, a new potent non-selective beta-adrenergic blocking drug with intrinsic sympathomimetic activity and weak membrane stabilizing activity, was evaluated alone and in comparison with oxprenolol, in six volunteers, at rest and during an exercise test.
(18) A variety of weak acids at and below their pK(a) are potent inhibitors of transport in Penicillium chrysogenum.
(19) It added that the crisis had highlighted significant weaknesses in financial regulation, with further measures needed to strengthen supervision.
(20) The radioprotective action in E. coli ATCC 9637 of ascorbate added to media containing the weak sensitizer, tetracycline (effect described by Pittillo and Lucas (1967)), was found to be dependent on the presence of metal catalysts of the autoxidation of ascorbate.