(a.) Pertaining to the foundation or basis; serving for the foundation. Hence: Essential, as an element, principle, or law; important; original; elementary; as, a fundamental truth; a fundamental axiom.
(n.) A leading or primary principle, rule, law, or article, which serves as the groundwork of a system; essential part, as, the fundamentals of the Christian faith.
Example Sentences:
(1) However, as the same task confronts the Lib Dems, do we not now have a priceless opportunity to bring the two parties together to undertake a fundamental rethink of the way social democratic principles and policies can be made relevant to modern society.
(2) "These developments are clearly unwarranted on the basis of economic and budgetary fundamentals in these two member states and the steps that they are taking to reinforce those fundamentals."
(3) The percent pause time, the standard deviation of the voice fundamental frequency distribution, the standard deviation of the rate of change of the voice fundamental frequency and the average speed of voice change were found to correlate to the clinical state of the patient.
(4) Some fundamentals of the causes of diagnostic errors depending upon anatomophysiological and topographo-anatomical peculiarities of woman's organism are given.
(5) Speaking to pro-market thinktank Reform, Milburn called for “more competition” and said the shadow health team were making a “fundamental political misjudgment” by attempting to roll back policies he had overseen.
(6) These data suggest that there are fundamental differences in the mechanisms of induction of virally and chemically induced thymic lymphomas in AKR mice.
(7) The findings support our earlier suggestion that the kinetics of spermatogenesis in the quail are fundamentally similar to the pattern which has been described for mammals.
(8) The crystallographic parameters of four different unit cells, all of which are based on hexagonal packing arrangements, indicate that the fundamental unit of the complex is composed of six gene 5 protein dimers.
(9) Which brings us to the next fundamental question: Was it a terrorist attack?
(10) The trials have yielded much fundamental and clinical data of general relevance in the radiotherapy of malignant disease.
(11) With an increased understanding of the fundamental biologic characteristics of brain tumors, we should be able to improve the outlook for these patients.
(12) The negative inotropic effect is fundamentally related to its effects on calcium release, with additional contributions from its effects on calcium entry.
(13) Thus functional plasticity in response to early experience appears to be a fundamental aspect of cortical development.
(14) In spite of this fundamental disagreement, they were both relieved that President Obama has suspended his plan to launch missiles against Syria .
(15) It is argued that the provision of accurate and useful probabilistic assessments of future events should be a fundamental task for biostatisticians collaborating in clinical or experimental medicine, and we explore two aspects of obtaining and evaluating such predictions.
(16) However, the most fundamental questions concerning the pathogenesis of Cushing's disease remain unanswered.
(17) The values of human dignity, freedom, democracy, equality, the rule of law and the respect for human rights are absolutely fundamental to the European Union.
(18) This study contains the fundamentals and the technique of the intraarticular application of an MRI contrast agent in connection with magnetic resonance imaging (MRI arthrography).
(19) Given that patient preferences constitute a central concept within the framework of HRQL, further empirical evaluation of utility measures of preference is fundamental to improving the HRQL measurement tool-kit.
(20) Our fundamental market is 75% done,” he said last weekend, “and when we sign one midfield player that crucial work will be done.” The manager did not rule out further purchases, though.
Intrinsic
Definition:
(a.) Inward; internal; hence, true; genuine; real; essential; inherent; not merely apparent or accidental; -- opposed to extrinsic; as, the intrinsic value of gold or silver; the intrinsic merit of an action; the intrinsic worth or goodness of a person.
(a.) Included wholly within an organ or limb, as certain groups of muscles; -- opposed to extrinsic.
(n.) A genuine quality.
Example Sentences:
(1) Although each of palate and limb is concurrently susceptible to epigenetic regulation, their differential intrinsic genomic capabilities appear to have been uncoupled.
(2) For enrolled nurses an increase in "Intrinsic Job Satisfaction" was less well maintained and no differences were found over time on "Patient Focus".
(3) The data indicate that adult neurons with an intrinsic ability to regenerate axons can respond to substances with neurotrophic or neurite-promoting activities in tissue cultures.
(4) Relative to the perceived severity of their asthma, both Maoris and Pacific Islanders lost more time from work or school and used hospital services more than European asthmatics using A & E. The increased use of A & E by Maori and Pacific Island asthmatics seemed not attributable to the intrinsic severity of their asthma and was better explained by ethnic, socioeconomic and sociocultural factors.
(5) On the other hand, the injection of minute quantities of endotoxin into PbAc(2)-sensitized rats invariably resulted in disseminated intravascular coagulation, apparently via a complete activation of the intrinsic pathway.
(6) Pathological changes may, thus, be initially confined to projecting and intrinsic neurons localized in cortical and subcortical olfactory structures; arguments are advanced which favor the view that excitotoxic phenomena could be mainly responsible for the overall degenerative picture.
(7) DL 071 IT, a new potent non-selective beta-adrenergic blocking drug with intrinsic sympathomimetic activity and weak membrane stabilizing activity, was evaluated alone and in comparison with oxprenolol, in six volunteers, at rest and during an exercise test.
(8) These results suggest that the majority of D1 and D2 receptors in prefrontal and anterior cingulate cortices are located postsynaptically on neurons intrinsic to the cortex.
(9) Intrinsic bending of the 527-bp fragment (bend center approximately at bp 240) was represented as a composite of at least two components located near bp 170 and near bp 260.
(10) This technique is sensitive to the optical anisotropy within the muscle, including that due to intrinsic properties of the protein molecules as well as that due to the regular arrangement of proteins in the surrounding medium.
(11) Using the results of a first evaluation made in 1989, a series of recommendations were made to reduce the prescription of drugs with a low intrinsic value (LIV).
(12) Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor.
(13) A plantar approach, implanting into the deep layer of intrinsics, was used.
(14) These data suggest that in terms of prolactin release, prolactin producing tumour cells are intrinsically refractory to hypo thalamic dopaminergic signals.
(15) Its isoelectric point is at pH 11.1 and intrinsic viscosity is 0.038 dl g-1 in 0.2 M NaCl.
(16) Within the restriction provided by surface area and volume, the intrinsic properties of the membrane and cytoplasm determine the deformability characteristics of the red cell.
(17) Quenching of intrinsic fluorescence of (Ca2+-Mg2+)-ATPase by acrylamide, performed in the presence of Ca2+, gave evidence for a single class of tryptophan residues with Stern-Volmer constant (KSV) of 10 M-1.
(18) This formalism allows resolution of the intrinsic protein folding-unfolding parameters (enthalpy, entropy, and heat capacity changes) as well as the ligand interaction parameters (binding stoichiometry, enthalpy, entropy, and heat capacity changes).
(19) This provides a compelling argument that the protein kinase function of p37mos is an intrinsic property of the protein.
(20) These data support the conclusion that there are mechanisms intrinsic to each tissue which exert a degree of control during growth over its chemical composition; therefore, growth itself can be considered an intrinsic regulatory mechanism.