(a.) Pertaining to the foundation or basis; serving for the foundation. Hence: Essential, as an element, principle, or law; important; original; elementary; as, a fundamental truth; a fundamental axiom.
(n.) A leading or primary principle, rule, law, or article, which serves as the groundwork of a system; essential part, as, the fundamentals of the Christian faith.
Example Sentences:
(1) However, as the same task confronts the Lib Dems, do we not now have a priceless opportunity to bring the two parties together to undertake a fundamental rethink of the way social democratic principles and policies can be made relevant to modern society.
(2) "These developments are clearly unwarranted on the basis of economic and budgetary fundamentals in these two member states and the steps that they are taking to reinforce those fundamentals."
(3) The percent pause time, the standard deviation of the voice fundamental frequency distribution, the standard deviation of the rate of change of the voice fundamental frequency and the average speed of voice change were found to correlate to the clinical state of the patient.
(4) Some fundamentals of the causes of diagnostic errors depending upon anatomophysiological and topographo-anatomical peculiarities of woman's organism are given.
(5) Speaking to pro-market thinktank Reform, Milburn called for “more competition” and said the shadow health team were making a “fundamental political misjudgment” by attempting to roll back policies he had overseen.
(6) These data suggest that there are fundamental differences in the mechanisms of induction of virally and chemically induced thymic lymphomas in AKR mice.
(7) The findings support our earlier suggestion that the kinetics of spermatogenesis in the quail are fundamentally similar to the pattern which has been described for mammals.
(8) The crystallographic parameters of four different unit cells, all of which are based on hexagonal packing arrangements, indicate that the fundamental unit of the complex is composed of six gene 5 protein dimers.
(9) Which brings us to the next fundamental question: Was it a terrorist attack?
(10) The trials have yielded much fundamental and clinical data of general relevance in the radiotherapy of malignant disease.
(11) With an increased understanding of the fundamental biologic characteristics of brain tumors, we should be able to improve the outlook for these patients.
(12) The negative inotropic effect is fundamentally related to its effects on calcium release, with additional contributions from its effects on calcium entry.
(13) Thus functional plasticity in response to early experience appears to be a fundamental aspect of cortical development.
(14) In spite of this fundamental disagreement, they were both relieved that President Obama has suspended his plan to launch missiles against Syria .
(15) It is argued that the provision of accurate and useful probabilistic assessments of future events should be a fundamental task for biostatisticians collaborating in clinical or experimental medicine, and we explore two aspects of obtaining and evaluating such predictions.
(16) However, the most fundamental questions concerning the pathogenesis of Cushing's disease remain unanswered.
(17) The values of human dignity, freedom, democracy, equality, the rule of law and the respect for human rights are absolutely fundamental to the European Union.
(18) This study contains the fundamentals and the technique of the intraarticular application of an MRI contrast agent in connection with magnetic resonance imaging (MRI arthrography).
(19) Given that patient preferences constitute a central concept within the framework of HRQL, further empirical evaluation of utility measures of preference is fundamental to improving the HRQL measurement tool-kit.
(20) Our fundamental market is 75% done,” he said last weekend, “and when we sign one midfield player that crucial work will be done.” The manager did not rule out further purchases, though.
Postulate
Definition:
(n.) Something demanded or asserted; especially, a position or supposition assumed without proof, or one which is considered as self-evident; a truth to which assent may be demanded or challenged, without argument or evidence.
(n.) The enunciation of a self-evident problem, in distinction from an axiom, which is the enunciation of a self-evident theorem.
(a.) Postulated.
(v. t.) To beg, or assume without proof; as, to postulate conclusions.
(v. t.) To take without express consent; to assume.
(v. t.) To invite earnestly; to solicit.
Example Sentences:
(1) We postulate that FAA may affect the human peripheral and mucosal immune system.
(2) This postulate is supported by a limited study of the serovars present among the isolates.
(3) Protein kinase C (PKC) is activated rapidly and transiently following ionizing radiation exposure and is postulated to activate downstream nuclear signal transducers.
(4) A new theory for the peculiar site selection of cholesteatomas of the external auditory canal is postulated.
(5) Both strong-stop DNAs are made early during in vitro reactions and decline in concentration later, consistent with postulated roles as initiators of long minus- and plus-strand DNA.
(6) Based on these findings and those described before, an overall degradation scheme is postulated.
(7) Their speech patterns, specifically pronoun use, were analyzed and support the postulate that a high frequency of self-references indicates memory loss and paucity of present experience.
(8) It has been postulated that the peroxisomal fatty acid-oxidizing system [Lazarow & de Duve (1976) Proc.
(9) The paper postulates that 'anal or sphincter defensiveness' is one of the precursors of the repression barrier.
(10) We postulate that an abnormality in retinal dopaminergic neurons, which are known to reduce light responsiveness of horizontal and ganglion cells, is the underlying pathophysiology of this clinical finding.
(11) We conclude, therefore, that a direct deacylation of the acyl groups at the primary alcohol level of the glycerol probably does not occur, but postulate that transacylations may occur to account for the removal of the acyl moiety.
(12) In addition, the postulated personality for PD may predispose to hard work, perspiration, and increased exposure to putative trace elements in the water supply.
(13) A regulatory role for GABA in the reproductive tract is postulated.
(14) A pathogenetic mechanism is postulated to explain the subacute evolution of fluid collection with diffusion of proteolytic enzymes between the splenic capsule and parenchyma.
(15) Therefore, it is not necessary to postulate a preponderant extraerythropoietic source to explain the amount of fecal excretion.
(16) The reason we have postulated that one-electron oxidation plays an important role in the activation of PAH derives from certain common characteristics of the radical cation chemistry of the most potent carcinogenic PAH.
(17) The postulated deficit is contrasted to the hypothesis of impairment to the lexical-semantic component, required to explain performance by brain-damaged subjects described elsewhere who make seemingly identical types of oral production errors to those of RGB and HW, but, in addition, make comparable errors in writing and comprehension tasks.
(18) The expression of keratin and differentiation markers was identical to that of normal keratinocytes, suggesting that psoriatic epidermal differentiation is not truncated in vitro as has been postulated to be the case in vivo.
(19) It is postulated that in case vasopressin affects retrieval processes the site of action is located in the amygdala and the dentate gyrus of the hippocampal complex with dopamine and serotonin as the respective neurotransmitter systems involved.
(20) More than 20 years ago Olney and his colleagues described the 'Excitotoxic Hypothesis' which postulates that, in addition to its normal function in the healthy brain, glutamate can kill neurons by prolonged, receptor-mediated depolarization resulting in irreversible disturbances in ion homeostasis.