(a.) Pertaining to the foundation or basis; serving for the foundation. Hence: Essential, as an element, principle, or law; important; original; elementary; as, a fundamental truth; a fundamental axiom.
(n.) A leading or primary principle, rule, law, or article, which serves as the groundwork of a system; essential part, as, the fundamentals of the Christian faith.
Example Sentences:
(1) However, as the same task confronts the Lib Dems, do we not now have a priceless opportunity to bring the two parties together to undertake a fundamental rethink of the way social democratic principles and policies can be made relevant to modern society.
(2) "These developments are clearly unwarranted on the basis of economic and budgetary fundamentals in these two member states and the steps that they are taking to reinforce those fundamentals."
(3) The percent pause time, the standard deviation of the voice fundamental frequency distribution, the standard deviation of the rate of change of the voice fundamental frequency and the average speed of voice change were found to correlate to the clinical state of the patient.
(4) Some fundamentals of the causes of diagnostic errors depending upon anatomophysiological and topographo-anatomical peculiarities of woman's organism are given.
(5) Speaking to pro-market thinktank Reform, Milburn called for “more competition” and said the shadow health team were making a “fundamental political misjudgment” by attempting to roll back policies he had overseen.
(6) These data suggest that there are fundamental differences in the mechanisms of induction of virally and chemically induced thymic lymphomas in AKR mice.
(7) The findings support our earlier suggestion that the kinetics of spermatogenesis in the quail are fundamentally similar to the pattern which has been described for mammals.
(8) The crystallographic parameters of four different unit cells, all of which are based on hexagonal packing arrangements, indicate that the fundamental unit of the complex is composed of six gene 5 protein dimers.
(9) Which brings us to the next fundamental question: Was it a terrorist attack?
(10) The trials have yielded much fundamental and clinical data of general relevance in the radiotherapy of malignant disease.
(11) With an increased understanding of the fundamental biologic characteristics of brain tumors, we should be able to improve the outlook for these patients.
(12) The negative inotropic effect is fundamentally related to its effects on calcium release, with additional contributions from its effects on calcium entry.
(13) Thus functional plasticity in response to early experience appears to be a fundamental aspect of cortical development.
(14) In spite of this fundamental disagreement, they were both relieved that President Obama has suspended his plan to launch missiles against Syria .
(15) It is argued that the provision of accurate and useful probabilistic assessments of future events should be a fundamental task for biostatisticians collaborating in clinical or experimental medicine, and we explore two aspects of obtaining and evaluating such predictions.
(16) However, the most fundamental questions concerning the pathogenesis of Cushing's disease remain unanswered.
(17) The values of human dignity, freedom, democracy, equality, the rule of law and the respect for human rights are absolutely fundamental to the European Union.
(18) This study contains the fundamentals and the technique of the intraarticular application of an MRI contrast agent in connection with magnetic resonance imaging (MRI arthrography).
(19) Given that patient preferences constitute a central concept within the framework of HRQL, further empirical evaluation of utility measures of preference is fundamental to improving the HRQL measurement tool-kit.
(20) Our fundamental market is 75% done,” he said last weekend, “and when we sign one midfield player that crucial work will be done.” The manager did not rule out further purchases, though.
Rationale
Definition:
(a.) An explanation or exposition of the principles of some opinion, action, hypothesis, phenomenon, or the like; also, the principles themselves.
Example Sentences:
(1) Topical and systemic antibiotic therapy is common in dermatology, yet it is hard to find a rationale for a particular route in some diseases.
(2) The nature of the putative autoantigen in Graves' ophthalmopathy (Go) remains an enigma but the sequence similarity between thyroglobulin (Tg) and acetylcholinesterase (ACHE) provides a rationale for epitopes which are common to the thyroid gland and the eye orbit.
(3) The rationale for using the high-risk-group research design in the search for the aetiology of schizophrenia is described.
(4) Pathophysiologic mechanisms and rationale for treatment are discussed.
(5) The rationale for this assumption seems logical because using all of the available accommodation is not sustainable without discomfort.
(6) The rationale for the use of exercise as part of the treatment program in type II diabetes is much clearer and regular exercise may be prescribed as an adjunct to caloric restriction for weight reduction and as a means of improving insulin sensitivity in the obese, insulin-resistant individual.
(7) The rationale for diagnosis and therapy is discussed.
(8) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(9) The rationale for using videofluoroscopy for rehabilitation, the implementation of videofluoroscopy for rehabilitation, and indications for using specific rehabilitation techniques during videofluoroscopy will be discussed.
(10) The rationale for pursuing the development and use of germ-line selection and modification techniques is examined in this essay.
(11) An experimental murine malarial model was devised using the highly synchronous species Plasmodium vinckei petteri to test this rationale.
(12) The wide variety of neurobehavioral effects produced by chemicals found in the environment argues for a rationale of tailoring test selection in many situations, particularly those where the range of expected effects has been fairly well established for the chemical under study.
(13) The homology thus revealed not only lends strong support to mechanisms of autoimmunity that invoke the theory of molecular mimicry of viral proteins, but also suggests a rationale for the skeletal muscle target of polymyositis.
(14) The relationship of these findings to the rationale of such procedures as segmental resection in the surgical treatment of breast cancer is discussed.
(15) The rationale of the method is outlined with emphasis on the management of traumatic oedema.
(16) Concluding the two-page survey were open-ended questions addressing the respondent's indications, contraindications, and rationale for using or not using fluoroscopy.
(17) This advantage may provide a rationale for further evaluation of this agent in patients with more widespread ventricular dysfunction.
(18) The evolution of and rationale for the combined surgical approach to coexistent carotid and coronary artery disease is discussed and the literature reviewed.
(19) Whether there is an additional cost-benefit rationale for handwashing with an antimicrobial agent remains to be studied.
(20) The first reviews the problems of heat stress evaluation: it describes the comprehensive approach adopted by ISO standards and in particular the rationale of the Required Sweat Rate index, and presents the work done during the ECSC interlaboratory study, which extends the application of this index to intermittent or fluctuating conditions of exposure.