(v. t.) To liquefy by heat; to render fiuid; to dissolve; to melt.
(v. t.) To unite or blend, as if melted together.
(v. i.) To be reduced from a solid to a Quid state by heat; to be melted; to melt.
(v. i.) To be blended, as if melted together.
(n.) A tube or casing filled with combustible matter, by means of which a charge of powder is ignited, as in blasting; -- called also fuzee. See Fuze.
Example Sentences:
(1) Synthetic DNA corresponding to the hydrophobic domain of cytochrome b5 was enzymatically fused in-frame to cloned DNA corresponding to the C-terminus of the Escherichia coli enzyme, beta-galactosidase.
(2) The latter findings reinforce the concept that in pathologic states associated with cerebral oedema, pinocytotic vesicles fuse to form transendothelial channels which transport plasma proteins into brain.
(3) DNA fragments coding for signal peptides with different lengths (28, 31, 33 and 41 amino acids from the translation initiator Met) were prepared and fused with the E. coli beta-lactamase structural gene.
(4) When these sequences were fused to the N terminus of yeast cytochrome oxidase subunit IV lacking its own presequence, they directed the attached subunit IV to its correct intramitochondrial location in vivo.
(5) In addition, 15 double mutant xylS genes were constructed in vitro by fusing parts of various mutant genes to produce mutant regulators exhibiting C-terminal and N-terminal amino acid substitutions.
(6) Descending neurons have opposite structural polarity, arising in the brain and terminating in segmental regions of the fused ventral ganglia.
(7) Some of them situated in a particular environment fused with the tail sequence to produce monomeric ubiquitin genes that were maintained across species.
(8) Fusing equimolecular amounts of 3-oxaspiro[5.5]undecane-2.4-dione with certain amino compounds afforded the corresponding N-substituted azaspirodiones.
(9) Theoretical analyses of parameters for submicron fluorescence recovery after photobleaching measurements in intact mitoplasts support the finding of highly mobile redox components diffusing at the same rates as determined in conventional fluorescence recovery after photobleaching measurements in fused, ultralarge inner membranes.
(10) A simple method has been developed for fusing synaptic vesicles into spherical structures 20-50 micron in diameter.
(11) The results obtained allow to conclude that heterophasic condition of the fused cells is one of the causes of pathological mitosis of polykaryons and of their death.
(12) At high protein concentrations, three footprints fuse to a 106-bp protected region, suggesting that this segment specifically binds several proteins of lower affinity or abundance.
(13) Traction spurs with segmental hypermobility were found more commonly at the L4-5 level in patients whose spines were not fused, particularly women.
(14) As for possible causes of reduced Leydig cell activity it was investigated whether the testis was (1) hypoplastic; (2) abnormally fused with the epididymis; (3) located in the abdomen; (4) or UT was associated with hypospadias.
(15) We report a case of seminoma associated with crossed fused renal ectopia and a duplicated vena cava.
(16) Large intracellular vacuoles, which arose from dilated cisternae of the rough-surfaced endoplasmic reticulum, were fused together, and marked swelling of the mitochondria was also noted.
(17) Apparently the myoblasts have become postmitotic and competent to fuse into muscle fibers during their initial exposure to fusion inducing medium, even though cytodifferentiation has been blocked.
(18) Our results clearly demonstrate that capillary GC analysis of amino acids using fused silica bonded-phase columns provides data with good precision and in general excellent agreement with ion-exchange analyses.
(19) We have perturbed the dynamics of the nuclear lamins by means of cell fusion between mitotic and interphase cells and have studied redistribution of lamins in fused cells as a function of extracellular pH levels.
(20) To identify regulatory elements of these promoters, we fused CSF-1R genomic sequences to bacterial reporter genes and introduced the resulting constructs into human cell lines and mouse fibroblasts.
Quinoline
Definition:
(n.) A nitrogenous base, C9H7N obtained as a pungent colorless liquid by the distillation of alkaloids, bones, coal tar, etc. It the nucleus of many organic bodies, especially of certain alkaloids and related substances; hence, by extension, any one of the series of alkaloidal bases of which quinoline proper is the type.
Example Sentences:
(1) The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed in vitro.
(2) The quinolinate synthetase B protein exists in all nadA and nadC mutants examined.
(3) Unilateral infusions of quinolinic acid (QUIN) into the rat striatum led to an increase in cholecystokinin octapeptide sulfate-like immunoreactivity (CCK8S-LI) in the striatum and substantia nigra 4 days later.
(4) A histochemical method for staining CNS zinc by the stoichiometric formation of zinc: quinoline fluorescent chelates is described.
(5) In contrast to other excitotoxins, such as kainic acid, quinolinic acid (QA) may spare a specific population of striatal neurons that is also spared in Huntington's disease (HD).
(6) Previous studies have shown that in lipopolysaccharide (LPS)-stimulated human monocytes, interleukin 1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.
(7) We conclude that quinolinic acid causes both reversible and long-lasting gliosis when injected into the rat striatum.
(8) The enzymic and non-enzymic formation of protein-arylating intermediates from amodiaquine (AQ,7-chloro-4-(3'-diethylamino-4'-hydroxyanilino) quinoline), an anti-malarial associated with agranulocytosis and liver damage in man, was studied in vitro.
(9) The ability of quinolinic acid to produce neurotoxicity was greater in the striatum than in other parts of the brain.
(10) The behavioral effects of 2-p-chlorophenylpyrazolo[4,3-c]quinolin-3(5H)-one (CGS 9896) were compared with those of lorazepam and zopiclone in squirrel monkeys.
(11) Synthetic heterocyclic quinones (107 samples) consisting of o- and p-quinoline quinones, o-isoquinoline quinones and p-quinoxaline quinones as well as o- and p-naphthoquinones (3 samples) were tested for their inhibitory activities against avian myeloblastosis virus reverse transcriptase (AMV-RT) and cytotoxic activities against mouse lymphoblastoma L5178Y cells.
(12) Ibotenate lesioned rats, despite having larger lesions than the quinolinate, showed no deficits in eating or drinking in the home cage, or reaching or grasping disabilities in the staircase test.
(13) Between the other toxins (kainate, AMPA, ibotenate, quisqualate, NMDA and the high dose of quinolinate) there were no statistically significant differences.
(14) possess anticonvulsant action against kynurenine and not against quinolinic acid.
(15) The quinoline nitrogen atom of quipazine also contributes to affinity and its replacement by carbon reduces affinity by 20-fold.
(16) The localization and distribution of quinolinic acid phosphoribosyltransferase, the degradative enzyme of the endogenous excitotoxin quinolinic acid, were studied in the post mortem human neostriatum by immunohistochemistry.
(17) The quinoline-containing antimalarial drugs chloroquine, quinine and mefloquine exert an irreversible inhibitory effect on erythrocytic stages of Plasmodium falciparum grown in culture.
(18) Bilateral intrastriatal injections of quinolinic acid (QA) (180 nmoles) induced weight loss and neurologic and behavioral deficits including convulsions, decreased catalepsy response to haloperidol, increased nocturnal locomotor activity, and abnormal feeding behavior in adult male Sprague-Dawley rats.
(19) Kainic acid and quinolinic acid were also effective in increasing the AAT activity.
(20) Diabetogenic and acidotropic effects of dithizone, 8-(p-toluenesulfonylamino)-quinoline and 8-(benzenesulfonylamino)-quinoline were studied in experiments on cats, rabbits, golden hamsters and mice.