(n.) A pointed or wedge-shaped instrument of metal, as a steel wedge used in mining, etc.
(n.) A sharp-pointed rod; a goad.
(n.) A spike on a gauntlet; a gadling.
(n.) A wedge-shaped billet of iron or steel.
(n.) A rod or stick, as a fishing rod, a measuring rod, or a rod used to drive cattle with.
(n.) To walk about; to rove or go about, without purpose; hence, to run wild; to be uncontrolled.
Example Sentences:
(1) N-Acetyl-beta-D-glucosaminidase (GAD) activities did not change significantly duringlate fetal, neonatal or young adult stages but increased significantly with advancing age.
(2) A more specific differentiation, as indicated by the sharp increase in GAD levels which was concurrent with an increase in interneuronal contacts, lagged behind the initial growth.
(3) GAD activity appeared in mutant spores after germination and increased to levels comparable to parent spores after 9 min of germination.
(4) In situ hybridization in normal visual cortex revealed a complex sublaminar organization of GAD-expressing cells within layers IVC and VI and a distribution of CaM II kinase alpha-expressing cells that was greatest in layers II, III, IVB, and VI.
(5) Neurogenesis of GABAergic neurons in the rat area dentata was studied combining [3H]thymidine autoradiography with immunostaining for glutamate decarboxylase (GAD), the gamma-aminobutyric acid (GABA) synthesizing enzyme.
(6) The presence of glutamic acid decarboxylase (GAD) and gamma-aminobutyric acid (GABA) was investigated in neuroretina sections from hatching quail embryos by immunocytochemistry.
(7) The hippocampal cell counts showed an increase in GAD-immunoreactive somata visualized on the fourth postischemic day.
(8) The postnatal maturation of the GABAergic innervation of the rat inferior olive was studied with an antiserum to glutamic acid decarboxylase (GAD), the GABA-synthesizing enzyme.
(9) In contrast, only modest alterations in GABA-immunoreactivity and glutamic acid decarboxylase (GAD) activity were observed in the same region.
(10) Approximately 25% of the neurons in the IC in SD rat are GAD-positive, while about 35% of the neurons in the GEPR are GAD-positive.
(11) The oxidation reaction ends in a mixture composed largely of oxidized GAD species.
(12) Although their numbers are greatest in the polymorph region of the fascia dentata (FD) and in the principal cell layers stratum pyramidale (SP) and stratum granulosum (SG), GAD immunoreactive (GAD-IR) cells are numerous in other strata that contain mostly dendrites and scattered cells.
(13) The methods and chemicals utilized were the same as those used and reported by Gad et al.
(14) However, the administration of thyroxine markedly increased CNPase activity in normal rats, whereas in hypothyroid rats the effect on both CNPase and GAD was also significant.
(15) No change in parameters of GABAergic activity, namely the glutamic acid decarboxylase (GAD) activity and high affinity GABA uptake, were observed in any of the structures examined.
(16) None of the drug treatments altered nigral GAD activity when examined after 1, 3, 6, 9 or 12 months administration.
(17) Addition of alkali to the culture media results in decrease of cell GAD activity, whereas increase of enzyme level occurs only in cells growing in unbuffered media.
(18) Vibratome sections of rat substantia nigra (SN) topically injected with colchicine were processed for glutamate decarboxylase (GAD) immunocytochemistry to reveal GABAergic neurons using electronmicroscopic procedures.
(19) GAD and ChAT omnipresence may indicate constant GABAergic HCII and its cholinergic efferent synapses, their raised content, appearance of GABA-containing HCI and related cholinergic boutons in higher vertebrates.
(20) Interestingly, the beta-galactosidase-GAD fusion protein encoded by lambda GAD is enzymatically active, catalyzing the conversion of glutamate to CO2 and GABA.
Mad
Definition:
(n.) A slattern.
(n.) The name of a female fairy, esp. the queen of the fairies; and hence, sometimes, any fairy.
() p. p. of Made.
(superl.) Disordered in intellect; crazy; insane.
(superl.) Excited beyond self-control or the restraint of reason; inflamed by violent or uncontrollable desire, passion, or appetite; as, to be mad with terror, lust, or hatred; mad against political reform.
(superl.) Proceeding from, or indicating, madness; expressing distraction; prompted by infatuation, fury, or extreme rashness.
(superl.) Extravagant; immoderate.
(superl.) Furious with rage, terror, or disease; -- said of the lower animals; as, a mad bull; esp., having hydrophobia; rabid; as, a mad dog.
(superl.) Angry; out of patience; vexed; as, to get mad at a person.
(superl.) Having impaired polarity; -- applied to a compass needle.
(v. t.) To make mad or furious; to madden.
(v. i.) To be mad; to go mad; to rave. See Madding.
(n.) An earthworm.
Example Sentences:
(1) Do [MPs] remember the madness of those advertisements that talked of the cool fresh mountain air of menthol cigarettes?
(2) Right from the beginning, I had been mad about movies.
(3) "This will be not only be a postcode lottery, but a States vs Europe lottery and that would be madness."
(4) It took years of prep work to make this sort of Übermensch thing socially acceptable, let alone hot – lots of “legalize it!” and “you are economic supermen!” appeals to the balled-and-entitled toddler-fists of the sociopathic libertechian madding crowd to really get mechanized mass-death neo-fascism taken mainstream .
(5) Or perhaps the "mad cow"-fuelled beef war in the late 1990s, when France maintained its ban on British beef for three long years after the rest of the EU had lifted it, prompting the Sun to publish a special edition in French portraying then president Jacques Chirac as a worm.
(6) • +33 2 98 50 10 12, hotel-les-sables-blancs.com , doubles from €105 room only Hôtel Ty Mad, Douarnenez Hôtel Ty Mad In the 1920s the little beach and fishing village of Douarnenez was a favourite haunt of the likes of Pablo Picasso and writer and artist Max Jacob.
(7) If you’re against the RFS, you’re going to make Iowans mad, you’re going to [have] some Iowans question you but the beauty of Iowa is you can take your case to the people,” said Kaufmann.
(8) In its more loose, common usage, it's a game in which the rivalry has come to acquire the mad, rancorous intensity of a Celtic-Rangers, a Real Madrid-Barcelona, an Arsenal-Tottenham, a River Plate-Boca Juniors.
(9) Yes, we can assign more or less responsibility – I blame Austria-Hungary and Germany for their mad determination to destroy Serbia knowing that a general war might result – but there is still plenty of room for disagreement.
(10) It’s good to hear a full-throated defence of social security as a basic principle of civilisation, and a reiteration of the madness of renewing Trident; pleasing too to behold how much Burnham and Cooper have had to belatedly frame their arguments in terms of fundamental principle.
(11) The blue skipping rope – that’s the key to this race.” My eight-year-old daughter looked at me like I was mad … but when it came time for the year 3 skipping race, she did as she was told – and duly chalked up a glorious personal best in third place.
(12) The policies of zero tolerance equip local and federal law-enforcement with increasingly autocratic powers of coercion and surveillance (the right to invade anybody's privacy, bend the rules of evidence, search barns, stop motorists, inspect bank records, tap phones) and spread the stain of moral pestilence to ever larger numbers of people assumed to be infected with reefer madness – anarchists and cheap Chinese labour at the turn of the 20th century, known homosexuals and suspected communists in the 1920s, hippies and anti-Vietnam war protesters in the 1960s, nowadays young black men sentenced to long-term imprisonment for possession of a few grams of short-term disembodiment.
(13) Maleic acid dimethylester (MAD) was investigated in acute and subacute dermal toxicity studies, for sensitization potential, and for in vivo and in vitro genotoxicity.
(14) Or maybe it's the other way round - the constant touring is a manifestation of their madness.
(15) And while one may think that the bishops of the Church of England don’t quite have the sex appeal of Russell Brand, we think that we should counter it.” While the bishops stress that their letter is not intended as “a shopping list of policies we would like to see”, they do advocate a number of specific steps, including a re-examination of the need for Trident, a retention of the commitment to funding overseas aid and a reassessment of areas where regulations fuel “the common perception of ‘health and safety gone mad’”.
(16) He still thinks Labour was mad to get him of all people to work inside the system.
(17) That has changed over the past few years as wallpaper has made a comeback and women have remembered that they like wearing madly patterned dresses – particularly leopard-print ones, or ones with huge flowers.
(18) Seeing the performance later in Edinburgh, I was impressed by Briers' ability to encompass the hero's rage and madness.
(19) It would be hard to allow working from home if I thought that they were all watching box sets of Mad Men.
(20) People thought she'd gone mad, but in retrospect it's clear that this was precisely what she needed in order to move forward.