(n.) A pointed or wedge-shaped instrument of metal, as a steel wedge used in mining, etc.
(n.) A sharp-pointed rod; a goad.
(n.) A spike on a gauntlet; a gadling.
(n.) A wedge-shaped billet of iron or steel.
(n.) A rod or stick, as a fishing rod, a measuring rod, or a rod used to drive cattle with.
(n.) To walk about; to rove or go about, without purpose; hence, to run wild; to be uncontrolled.
Example Sentences:
(1) N-Acetyl-beta-D-glucosaminidase (GAD) activities did not change significantly duringlate fetal, neonatal or young adult stages but increased significantly with advancing age.
(2) A more specific differentiation, as indicated by the sharp increase in GAD levels which was concurrent with an increase in interneuronal contacts, lagged behind the initial growth.
(3) GAD activity appeared in mutant spores after germination and increased to levels comparable to parent spores after 9 min of germination.
(4) In situ hybridization in normal visual cortex revealed a complex sublaminar organization of GAD-expressing cells within layers IVC and VI and a distribution of CaM II kinase alpha-expressing cells that was greatest in layers II, III, IVB, and VI.
(5) Neurogenesis of GABAergic neurons in the rat area dentata was studied combining [3H]thymidine autoradiography with immunostaining for glutamate decarboxylase (GAD), the gamma-aminobutyric acid (GABA) synthesizing enzyme.
(6) The presence of glutamic acid decarboxylase (GAD) and gamma-aminobutyric acid (GABA) was investigated in neuroretina sections from hatching quail embryos by immunocytochemistry.
(7) The hippocampal cell counts showed an increase in GAD-immunoreactive somata visualized on the fourth postischemic day.
(8) The postnatal maturation of the GABAergic innervation of the rat inferior olive was studied with an antiserum to glutamic acid decarboxylase (GAD), the GABA-synthesizing enzyme.
(9) In contrast, only modest alterations in GABA-immunoreactivity and glutamic acid decarboxylase (GAD) activity were observed in the same region.
(10) Approximately 25% of the neurons in the IC in SD rat are GAD-positive, while about 35% of the neurons in the GEPR are GAD-positive.
(11) The oxidation reaction ends in a mixture composed largely of oxidized GAD species.
(12) Although their numbers are greatest in the polymorph region of the fascia dentata (FD) and in the principal cell layers stratum pyramidale (SP) and stratum granulosum (SG), GAD immunoreactive (GAD-IR) cells are numerous in other strata that contain mostly dendrites and scattered cells.
(13) The methods and chemicals utilized were the same as those used and reported by Gad et al.
(14) However, the administration of thyroxine markedly increased CNPase activity in normal rats, whereas in hypothyroid rats the effect on both CNPase and GAD was also significant.
(15) No change in parameters of GABAergic activity, namely the glutamic acid decarboxylase (GAD) activity and high affinity GABA uptake, were observed in any of the structures examined.
(16) None of the drug treatments altered nigral GAD activity when examined after 1, 3, 6, 9 or 12 months administration.
(17) Addition of alkali to the culture media results in decrease of cell GAD activity, whereas increase of enzyme level occurs only in cells growing in unbuffered media.
(18) Vibratome sections of rat substantia nigra (SN) topically injected with colchicine were processed for glutamate decarboxylase (GAD) immunocytochemistry to reveal GABAergic neurons using electronmicroscopic procedures.
(19) GAD and ChAT omnipresence may indicate constant GABAergic HCII and its cholinergic efferent synapses, their raised content, appearance of GABA-containing HCI and related cholinergic boutons in higher vertebrates.
(20) Interestingly, the beta-galactosidase-GAD fusion protein encoded by lambda GAD is enzymatically active, catalyzing the conversion of glutamate to CO2 and GABA.
Spike
Definition:
(v. t.) To set or furnish with spikes.
(v. t.) To fix on a spike.
(n.) A sort of very large nail; also, a piece of pointed iron set with points upward or outward.
(n.) Anything resembling such a nail in shape.
(n.) An ear of corn or grain.
(n.) A kind of flower cluster in which sessile flowers are arranged on an unbranched elongated axis.
(v. t.) To fasten with spikes, or long, large nails; as, to spike down planks.
(v. t.) To stop the vent of (a gun or cannon) by driving a spike nail, or the like into it.
(n.) Spike lavender. See Lavender.
Example Sentences:
(1) It was tested for recovery and separation from other selenium moieties present in urine using both in vivo-labeled rat urine and human urine spiked with unlabeled TMSe.
(2) The pons, on the other hand, has a bioelectrical activity of its own during PS, i.e., the ponto-geniculo-occipital spikes (PGO).
(3) The spikes likely correspond to VP3, a hemagglutinin, while the rest of the mass density in the outer shell represents 780 molecules of VP7, a neutralization antigen.
(4) In this series there were 45 patients (40%) with independent focal interictal EEG epileptic abnormalities over frontobasal cortex (with or without independent spiking over interomedial temporal region).
(5) It was shown that gradual recovery of spike wave patterns occurred from initial water swallowing to successive dry swalllowing.
(6) One might expect that a similar news spike and rebounding of support for stricter gun control can happen, given President Obama's new push.
(7) By this action, oxytocin is believed to increase the probability of successful regenerative spikes and thereby initiate electrical activity in quiescent preparations, increase the frequency of burst discharges, the number of spikes in each burst, and the amplitude of spikes in individual cells.
(8) The differentiated neuroblastoma cell possesses characteristics of an electrically excitable cell and can generate propagated potential spikes in which Ca2+ is the inward charge carrier.
(9) Jane's life clearly still has a massive Spike-shaped hole in it.
(10) Our hypothesis is that phase unlocking may be one of the induction mechanisms of spike-burst activity.
(11) The threshold of epileptic spiking varied inversely with the area of cortical damage inflicted by the electrode.
(12) In some ways, the Gandolfini performance that his fans may savour most is his voice work in Spike Jonze's Where the Wild Things Are (2009), the cult screen version of Maurice Sendak 's picture book classic – he voiced Carol, one of the wild things, an untamed, foul-mouthed figure.
(13) The best understood fusion mechanism is that of influenza virus, for which sequences involved in pH-dependent fusion can be correlated with the crystallographic structure of the spike protein.
(14) Single shocks applied to medullary pressor sites evoked a train of spikes in the interneurons.
(15) Many subjects have a negative spike in the beginning of a saccade in electro-oculographic signals.
(16) This enhancement of laminin synthesis corresponds to the mesangial expansion and to the development of laminin-containing spike formations of the glomerular basement membrane at week 8.
(17) A train of conditioning stimuli to either of the midbrain nuclei produced inhibition of evoked population spikes recorded in the CA1 pyramidal cell layer of the hippocampus.
(18) The brief (3 ms) afterhyperpolarizations that followed such spikes were blocked by intracellular injections of Cs+ or by bath applications of tetraethylammonium.
(19) They discharged one or two spikes only at the beginning of depolarizing current pulses.
(20) An increase followed by a decrease in the number of spikes per burst and a reduction in the peak activity were observed.