(1) Coronary spasm was provoked by ergonovine maleate in four of 12 patients in group A (33%) and in three patients in group B (18%).
(2) Guinea pigs immunized by repeated exposure to aerosolized ovalbumin (OA) were intravenously given metopirone, a cortisol synthesis inhibitor, 24 hrs before and 30 min before antigen challenge, and to prevent death from immediate severe bronchoconstriction, chlorpheniramine maleate was also injected.
(3) This complex is characterized by an increased absorption at 430 nm together with a positive Cotton effect, as also observed in the case of the complex with the competitive inhibitor maleate indicating protonation of the internal aldimine.
(4) Liver was the most responsive to these agents in that all 11 chemicals increased MT concentrations in liver, with diethyl maleate, paraquat, and diamide producing 20- to 30-fold increases.
(5) Enalapril maleate (25 mg.kg-1.day-1 in drinking water) was started at 4-5 weeks of age.
(6) Tartaric acid-evoked contractions of the rat isolated fundus could not be antagonized by atropine sulphate or methysergide hydrogen maleate, but were partially reduced by mepyramine hydrochloride.
(7) We evaluated the efficacy of perhexiline maleate, a drug with an antianginal mechanism of action in humans that is as yet unknown, by using a randomized double-blind placebo-controlled crossover design in 17 patients with refractory angina who continued to receive maximal antianginal therapy, typically including nitrates, a beta-blocker, and a calcium channel antagonist.
(8) Methylergonovine maleate produced painful oesophageal abnormal contractions in 5 of the 6 patients in group A.
(9) Neither other vasodilator agents (acetylcholine, tolazoline, histamine, isoproterenol, sodium arachidonate, the prostaglandin analog CL115, 347) nor vasoconstrictor substances (norepinephrine, epinephrine, phenylephrine, and ergonovine maleate) produced the same effect.
(10) A compound, 1'-methyl spiro (adamantane-2,3'-pyrrolidine) maleate, chemically related to the antiviral drug amantadine, was tested for activity in vitro against a number of human respiratory viruses.
(11) Flupirtine maleate is a centrally acting analgesic with a novel chemical structure and pharmacological profile.
(12) Contractions induced by 8-hydroxy-2-(di-n-propylamino)-tetralin or alpha-methylserotonin maleate were attenuated by pretreatment with S(-)propranolol (2.6 microM), a relatively selective 5-HT1A and 5-HT1B receptor antagonist, and ketanserin (0.3 microM), a selective 5-HT2 receptor antagonist, respectively.
(13) Stable incubation medium was achieved by using tartrate, instead of maleate, as chelating for lead.
(14) The effect of treatment with the potent, non-competitive NMDA receptor-channel antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a, d] cyclohepten-5,10-imine maleate (MK-801) on ischemia-induced brain damage was studied in a well-characterized model of focal neocortical infarction in spontaneously hypertensive rats.
(15) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(16) As an extension of these studies, the present paper first reports (i) an experimental investigation of the tendency of four dicarboxylic acids, namely malate, malonate, tartrate and maleate, to mixed-ligand coordination with zinc and histamine, (ii) computer-based potential effects to be expected from the association of these agents to zinc with respect to histamine tissue diffusion.
(17) Two antihistamines, orally administered chlorpheniramine maleate (CM) and diphenhydramine hydrochloride (DH) administered by intranasal spray, were used under double-blinded, randomized, placebo-controlled conditions to assess both tolerance and efficacy in volunteers with experimental rhinovirus (RV) colds.
(18) Timolol maleate is a nonselective beta-blocking drug used for the topical treatment of increased intraocular pressure in patients with chronic open angle glaucoma.
(19) The pharmacokinetics of dimetindene (dimethindene maleate, Fenistil, CAS 3614-69-5) were studied after its intravenous and oral administration to 8 healthy male volunteers.
(20) Treatment with diethyl maleate prior to rubratoxin B administration caused an 80% reduction in hepatic and a 70% reduction in renal NPSH concentration, which was prolonged by rubratoxin B treatment.