(n.) A spout projecting from the roof gutter of a building, often carved grotesquely.
Example Sentences:
(1) Their intellect is normal and they have no gargoyle-like features.
(2) Bill Nighy plays the king of the demons; Miranda Otto the gargoyle queen.
(3) beta-Mannosidase deficiency was demonstrated in fibroblasts of a girl who showed severe psychomotor retardation, bone deformities and gargoylism and recurrent skin and respiratory infections and who died at 20 years of age from bronchopneumonia.
(4) In various tissues from patients with gargoylism, deficiency of beta-galactosidase A could be demonstrated.
(5) The high level of mannose in the liver from gargoylism patients seems to indicate storage of glycopeptide, adding a new group of substances to those known to be stored in gargoylism.
(6) An autopsy case of a 19-year-old boy who had shown typical gargoyle features, strictly consistent with mucopolysaccharidosis type II (Hunter's syndrome) was reported.
(7) The reversed conditions could be caused by the difference of increased aMPS; i.e., dermatan sulfate B or heparitin sulfate in gargoylism, on the contrary, dermatan sulfate A and C or hyaluronic acid in Marfan syndrome.
(8) An adult patient with macular cherry-red spots, a gargoyle-like physical appearance, cerebellar ataxia, myoclonus, convulsive seizures, and pyramidal tract signs showed a profound deficiency of beta-galactosidase in liver and brain.
(9) The patient had a gargoyle-like face, bone change with cherry-red spot and absence of mucopolysacchariduria, and moreover accompanied by hereditary thrombocytopathy and color blindness.
(10) The nature of the basic defect in gargoylism is discussed.
(11) It must however be mentioned that the most frequent mucopolysaccharidosis, Sanfilippo's disease, and other forms of mucopolysaccharidoses (MPSoses) are not showing gargoylism.
(12) As grim as a gargoyle, craggy as a crag, jaw set in steel – even the famous smirk was well hidden behind the scowl.
(13) The present paper describes 3 out of a total of 9 siblings, aged 9, 17, and 18, with the following symptoms: gargoyle-like facial features, clouding of the cornea in both eyes, dysostosis multiplex, slightly impaired intelligence, hepatosplenomegaly, umbilical hernia, and increased secretion of mucopolysaccharides in the urine, in particular dermatan and heparan sulfate.
(14) Cellulose acetate electrophoresis differentiated clearly between the two major forms of gargoylism, the Hurler and Sanfilippo syndromes, but differentiation between the Hurler, Hunter, and Scheie syndromes was more difficult on electrophoretic data alone.
(15) The samples analyzed were obtained from control subjects, patients with gargoylism, and patients with a few other kinds of storage disorders.
(16) Studies in the morphology, histochemistry, and ultrastructure of the cerebellum, with special reference to the Purkinje cell dendrites, have been undertaken in eight cases of gargoylism.
(17) Still though, the obsession with personality, the grand gargoyles of the dugout over, say, tactics and development remains.
(18) In newspapers, cartoons squat like gargoyles on top of the columns, and while you nibble your way through the columnists' prose for several minutes, you swallow the cartoon whole in seconds.
(19) An autopsy case of a 9 years and 5 months old gargoyle girl diagnosed as Sanfilippo B syndrome by the biochemical demonstration of a large amount of heparan sulfate in urine and some organs and of deficiency of alpha-N-acetyl-D-glucosaminidase in the liver and brain was reported.
(20) A 17-year-old patient clinically manifesting gargoyle face, dwarfism, skeletal bone deformity, mild mental retardation and benign course was presented.
Grotesque
Definition:
(n.) A whimsical figure, or scene, such as is found in old crypts and grottoes.
(n.) Artificial grotto-work.
Example Sentences:
(1) There was some fertile ground in which that grotesque lie could be sown.
(2) There are allegations of very, very serious dereliction of duty and of wrongdoing by people in the police at the time who were investigating – it is alleged – some of the most grotesque crimes imaginable.” According to Newsnight, the officers involved said they did not know the senior figure who threatened them.
(3) That's completely and utterly grotesque and, no matter how proud we all are in the labour movement that the minimum wage exists, not a single day goes by that we shouldn't be disgusted with ourselves for that.
(4) They look like grotesque open-air swimming pools - and they contain some of the UK's biggest problems regarding nuclear waste.
(5) I still believe that the diversion of ever wider tracts of arable land from feeding people to feeding livestock is iniquitous and grotesque.
(6) The voices of the other characters – Thomas's mother as well as a cast of recognisable grotesques: a taxi driver, a bully, the local drunk – add to the atmosphere of dissolving reality and, at times, to the sense that they may exist only in Magill's head.
(7) The grotesque merry-go-round of more people selling fewer overpriced homes is in full swing.
(8) Jimmy Savile told hospital staff he interfered with patients' corpses, taking grotesque photographs and stealing glass eyes for jewellery, over two decades at the mortuary of Leeds general infirmary.
(9) A combination of dysfunctional family and invasive fame ate away at the essentially private singer, whose initially minor eccentricities escalated into grotesque changes to his appearance and lifestyle.
(10) The church cannot face in two directions like a grotesque two-headed monster: one face for public, the other for private.
(11) O'Brien has since become notorious among equal rights campaigners for his vigorous attacks on gay marriage and gay adoptions , calling homosexuality a "grotesque subversion" and "harmful to the physical, mental and spiritual wellbeing of those involved".
(12) He will still be lauded by those who enjoy this grotesque, sadistic sport, whatever his views on gay people or women.
(13) The model is then subjected to the criticism that it is grotesque to ignore questions relating to the value of, for example, a productive mother over against an aged recluse, and to treat them as having equal rights to access.
(14) Outside, all the talk was of the corruption allegations that had led to a fresh wave of hand-wringing over the greed and grotesque sums in the game.
(15) His once-visionary keywords have grotesque afterlives: Big Brother is a TV franchise to make celebrities of nobodies and Room 101 a light-entertainment show on BBC2 currently hosted by Frank Skinner for celebrities to witter about stuff that gets their goat.
(16) To put it plainly, PFI charges include too high a rate of interest and grotesquely high returns on equity.
(17) But he made grotesque monetary demands for the nonsense of Superman.
(18) His conclusion, outlined in The Book of Matt: Hidden Truths about the Murder of Matthew Shepard , is that the grotesque murder was not a hate crime, but could instead be blamed on crystal meth, a drug that was flooding Denver and the surrounding area at the time of Matthew’s death.
(19) It's that to portray Israel as some kind of victim with every right to "defend itself" from attack from "outside its borders" is a grotesque inversion of reality.
(20) It also contains a grotesquely racist portrayal of an Asian neighbour by Mickey Rooney.