(n.) A spout projecting from the roof gutter of a building, often carved grotesquely.
Example Sentences:
(1) Their intellect is normal and they have no gargoyle-like features.
(2) Bill Nighy plays the king of the demons; Miranda Otto the gargoyle queen.
(3) beta-Mannosidase deficiency was demonstrated in fibroblasts of a girl who showed severe psychomotor retardation, bone deformities and gargoylism and recurrent skin and respiratory infections and who died at 20 years of age from bronchopneumonia.
(4) In various tissues from patients with gargoylism, deficiency of beta-galactosidase A could be demonstrated.
(5) The high level of mannose in the liver from gargoylism patients seems to indicate storage of glycopeptide, adding a new group of substances to those known to be stored in gargoylism.
(6) An autopsy case of a 19-year-old boy who had shown typical gargoyle features, strictly consistent with mucopolysaccharidosis type II (Hunter's syndrome) was reported.
(7) The reversed conditions could be caused by the difference of increased aMPS; i.e., dermatan sulfate B or heparitin sulfate in gargoylism, on the contrary, dermatan sulfate A and C or hyaluronic acid in Marfan syndrome.
(8) An adult patient with macular cherry-red spots, a gargoyle-like physical appearance, cerebellar ataxia, myoclonus, convulsive seizures, and pyramidal tract signs showed a profound deficiency of beta-galactosidase in liver and brain.
(9) The patient had a gargoyle-like face, bone change with cherry-red spot and absence of mucopolysacchariduria, and moreover accompanied by hereditary thrombocytopathy and color blindness.
(10) The nature of the basic defect in gargoylism is discussed.
(11) It must however be mentioned that the most frequent mucopolysaccharidosis, Sanfilippo's disease, and other forms of mucopolysaccharidoses (MPSoses) are not showing gargoylism.
(12) As grim as a gargoyle, craggy as a crag, jaw set in steel – even the famous smirk was well hidden behind the scowl.
(13) The present paper describes 3 out of a total of 9 siblings, aged 9, 17, and 18, with the following symptoms: gargoyle-like facial features, clouding of the cornea in both eyes, dysostosis multiplex, slightly impaired intelligence, hepatosplenomegaly, umbilical hernia, and increased secretion of mucopolysaccharides in the urine, in particular dermatan and heparan sulfate.
(14) Cellulose acetate electrophoresis differentiated clearly between the two major forms of gargoylism, the Hurler and Sanfilippo syndromes, but differentiation between the Hurler, Hunter, and Scheie syndromes was more difficult on electrophoretic data alone.
(15) The samples analyzed were obtained from control subjects, patients with gargoylism, and patients with a few other kinds of storage disorders.
(16) Studies in the morphology, histochemistry, and ultrastructure of the cerebellum, with special reference to the Purkinje cell dendrites, have been undertaken in eight cases of gargoylism.
(17) Still though, the obsession with personality, the grand gargoyles of the dugout over, say, tactics and development remains.
(18) In newspapers, cartoons squat like gargoyles on top of the columns, and while you nibble your way through the columnists' prose for several minutes, you swallow the cartoon whole in seconds.
(19) An autopsy case of a 9 years and 5 months old gargoyle girl diagnosed as Sanfilippo B syndrome by the biochemical demonstration of a large amount of heparan sulfate in urine and some organs and of deficiency of alpha-N-acetyl-D-glucosaminidase in the liver and brain was reported.
(20) A 17-year-old patient clinically manifesting gargoyle face, dwarfism, skeletal bone deformity, mild mental retardation and benign course was presented.
Ugly
Definition:
(superl.) Offensive to the sight; contrary to beauty; being of disagreeable or loathsome aspect; unsightly; repulsive; deformed.
(superl.) Ill-natured; crossgrained; quarrelsome; as, an ugly temper; to feel ugly.
(superl.) Unpleasant; disagreeable; likely to cause trouble or loss; as, an ugly rumor; an ugly customer.
(n.) A shade for the face, projecting from the bonnet.
(v. t.) To make ugly.
Example Sentences:
(1) Pyongyang also called the UN security council an "ugly product of American-led international pressure".
(2) Richard now is presented, albeit somewhat inconsistently, as evil in response to social ostracism because of his ugly deformities.
(3) It is clearly painful for her to keep talking about Larsson's death, and the ugliness and upheaval that has come since.
(4) It created a very ugly atmosphere in society – as I was growing up in politics, I disliked the hypocrisy where people had to conceal their own identity.
(5) This would probably end in an ugly fight on the floor of the convention where delegates (almost of whom are selected in a process separate from the actual primary ) are free to vote on the rules however they want.
(6) To suggest that people who are concerned about the use of a power of this sort against journalists are condoning terrorism, which seems to be the implication of that remark, is an extremely ugly and unhelpful sentiment.
(7) When it transpired that he had, if not in the way he might have wanted, he and his corner leapt in the air, before the realization of the ugly mood of the crowd muted the celebrations.
(8) With panic-inducing stories of deaths, rising infection rates and government failure to advertise the annual vaccination campaign, flu has once again reared its ugly head in our newspapers and across TV screens.
(9) He cites the shockingly ugly examples of "predict" and "extraneous".
(10) No, for all of its ugly tenor, that statement has long been true under the law; corporations have long existed as a concept by which business interests could have the legal standing of individuals.
(11) The good has been off-the-wall inspiring, and the ugly made me doubt humanity.” Steve Huffman, a Reddit founder and former CEO, will return to the top job.
(12) To be talking of relocating people off their traditional country does indeed take us back 50 years in a very ugly way.” Barnett has said there is no other option but closure of between 100 and 150 communities which it has described as “unviable”, and cited “high rates of suicide, poor education, poor health [and] no jobs”.
(13) I’m a maniac and everyone on this stage is stupid, fat and ugly,” he deadpanned.
(14) So it will have been a wrench for Jez, and his embattled entourage, to have to “cave in”, as the Guardian’s report put it, and suspend the MP from the party after David Cameron (who really should leave the rough stuff to the rough end of the trade) had taunted him at PMQs for not acting sooner when the Guido Fawkes blog republished her ugly comments and the Mail on Sunday got out its trumpet.
(15) We lived on the 10th floor of one of Moscow's post-communist-era apartment blocks, an ugly, orange-brick tower in the Moscow suburb of Voikovskaya.
(16) Sixty-one headteachers wrote to the papers in support a couple of days later, but they were swept away by a campaign notable for the ugliness it permitted in some of its readers.
(17) After a £559m loss in the first half, he told the Guardian last week that the annual numbers would be "ugly" .
(18) Captain America kicking open the door of what looks like a European mountain fortress suggests the Nazi offshoot Hydra might be rearing its many ugly heads once again.
(19) The run of unpredictable weather this season has left farmers and growers with bumper crops of "ugly" fruit and vegetables with reported increases in blemishes and scarring, as well as shortages due to later crops.
(20) In many ways, I wasn't shocked with the physical threats and ugly language.