(1) The rate-limiting step for O2, NO, and isonitrile binding to all five proteins is ligand migration up to the initial geminate state, and the rate of this process determines the overall bimolecular association rate constant for these ligands.
(2) Analysis of the effect of photoselection by the linearly polarized excitation pulse indicates that a major contribution to the apparent geminate rebinding in the 50-ns relaxation arises from rotational diffusion of molecules containing unphotolyzed heme-CO complexes.
(3) This is due to the influence of the fluorine substituent(s) on the basicity of the amine function proximal to the fluoromethylene group, this effect being amplified by geminal disubstitution.
(4) Significant subnanosecond geminate recombination is observed in oxyhemoglobin down to 150 K, while below 100 K this geminate recombination disappears.
(5) In addition, the first prevalence statistics for the bilateral occurrence of fusion and gemination in the primary and permanent dentitions are determined.
(6) We discuss geminate recombination measurements of cyanomet hybrid hemoglobins with NO and consider these results in terms of alpha and beta subunit heterogeneity.
(7) The results were analyzed quantitatively in terms of a three-step reaction scheme, MbX in equilibrium B in equilibrium C in equilibrium Mb + X, where Mb is myoglobin, B represents a geminate state in which the ligand is present in the distal pocket but not covalently bound to the iron atom, and C, a state in which the ligand is still embedded in the protein but further away from the heme group.
(8) The picosecond geminate rebinding of molecular oxygen was monitored in a variety of different human, reptilian, and fish hemoglobins.
(9) Comparing the kinetic and thermodynamic process of the O2 geminate reaction among several Mbs, we concluded that the geminate O2 reaction with Mb is governed by the dynamic motion of the protein which is sensitively controlled by the static interaction of the heme moiety with the surroundings.
(10) The geminal nature of the magnitude-COSY detected partners to the resolved C beta H peaks is confirmed by strong NOESY cross-peaks.
(11) Typical geminate virus particles were observed in extracts of plants infected with ORF AC3 mutants indicating that this gene is not essential for coat protein synthesis or virus assembly but possibly acts by modulating virus levels in infected tissues.
(12) However, the rates of geminate recombination of NO and O2 and the affinity of myoglobin for O2 were dependent upon the basicity of residue 45.
(13) The vicinal (vic) isomer was excreted in a 2 times higher amount (16 nmol) than the geminal (gem) isomer (8 nmol).
(14) The fraction geminate signal was least at delays where the maximum proportion of liganded T state tetramer is expected.
(15) Geminate recombination phases were observed at 30 ns and 1 microsecond following photodissociation.
(16) It is suggested that all succedaneous teeth that are joined or fused together by dentin be referred to as fused teeth because of the frequent difficulty in differentiating fusion and gemination in the adult dentition.
(17) The geminal beta-methylene protons for the two cysteines bound to the iron(II) center were clearly identified, as well as the C alpha H and one C beta H for each of the cysteines bound to the iron(III).
(18) Measurement of the geminate process in the infrared CO-stretch bands shows distributed activation enthalpies with different distributions for each band, transitions between two bands that correspond to photolyzed ligands, and kinetic hole burning.
(19) The kinetics of geminate recombination for the diliganded species alpha 2CO beta 2 and alpha 2 beta 2CO of human hemoglobin were studied using flash photolysis.
(20) Flash photolysis kinetics of carbon monoxide hemoglobin show a decrease in the fraction of ligand recombination occurring as geminate when the hemoglobin has fewer ligands bound.
Seminal
Definition:
(a.) Pertaining to, containing, or consisting of, seed or semen; as, the seminal fluid.
(a.) Contained in seed; holding the relation of seed, source, or first principle; holding the first place in a series of developed results or consequents; germinal; radical; primary; original; as, seminal principles of generation; seminal virtue.
(n.) A seed.
Example Sentences:
(1) In normal seminal vesicle, the reaction product was apparently more abundant in columnar and basal cells than in other cell types.
(2) 500-MHz H-NMR spectroscopy of the oligosaccharides derived from gamma-seminoprotein, a human seminal plasma glycoprotein, revealed considerable microheterogeneity both with respect to the degree of branching and with regard to the peripheral sugars.
(3) GC using the capillary columns proved suitable for mapping of the carbohydrate profile of human seminal fluid and for the analyses of organic compounds accumulating in human adipose tissue.
(4) The corresponding values for 1 ml seminal plasma were: 1-50, 0-439, 0-581, 0-594 and 0-010 mg.
(5) Air-regenerated monomers of bovine seminal ribonuclease have been found capable of reassociating into native dimers, whereas monomers refolded in the presence of a glutathione redox mixture do not reassociate into dimers [Smith, K. G., D'Alessio, G. and Schaffer, S. W. (1978) Biochemistry 17, 2633-2638].
(6) Repeated administration of high concentrations (10 muglml and above) of histamine produce tachyphylaxis in the seminal vesicle of guinea pig.
(7) This report describes the cytotoxic properties of human seminal plasma and demonstrates that the inhibition of response to mitogens shown by murine lymphocytes in the presence of whole human seminal plasma can be attributed largely to an effect of seminal components on lymphocyte viability.
(8) Immunoelectron microscopy of the rat seminal vesicle was performed using specific antibodies to secretory proteins.
(9) The effect of SV-IV, one of the major proteins secreted from the rat seminal vesicle epithelium, on phagocytosis and chemotaxis of human polymorphonuclear leukocytes (PMNs) has been studied.
(10) Volume of prostate and seminal vesicles was measured in patients with Klinefelter's syndrome by means of transrectal ultrasonography before and after testosterone replacement therapy.
(11) However the diagnostic accuracy of an elevated serum antigen level on an individual basis was only 55 per cent for capsular penetration and 50 per cent for seminal vesicle involvement and lymph node involvement.
(12) The previous demonstration that sperm kept at body temperature (37 degrees C) had a marked deterioration in motility accompanied by an overgrowth of bacteria in the semen and a concomitant decrease in pH led to this study to test the hypothesis that the decrease in motility was caused by the bacteria or by bacterial alteration of seminal pH.
(13) The mean length of the seminal vesicles was 2.98 cm.
(14) The seminal degeneration and regeneration associated with the development and spontaneous cure of scrotal mange were very similar to that seen following experimental elevation of testicular temperature.
(15) The acrosin inhibitors are localized in the mucosa cells of the cauda epididymis, the vas deferens, the seminal vesicles, the urethra and distinct glandular units of the prostate.
(16) The maximum labelling indices which appeared on days 2 or 3 of administration of methyltestosterone were 24.3, 8.4, 9.6, 21.6 and 13.7% for the ventral, lateral and dorsal prostate, seminal vesicle and coagulating glands, respectively.
(17) It was concluded that the heat-induced substance(s) from leukocytes, which being highly possible the Hsps, interfered the mobility of wash human sperm and the inhibition might be antagonized by seminal plasma.
(18) Basic peptides (bovine pancreatic trypsin inhibitor, bull seminal isoinhibitors of trypsin, arginine vasopressin and adamantylamide-alanylisoglutamine) were analysed with a cationic ITP system at acidic pH.
(19) Relaxin in seminal fluid was determined radioimmunologically in 238 andrological patients with various ejaculate qualities.
(20) We have previously described the presence of a human seminal plasma component which may prevent the immunologic sensitization of females against sperm and seminal plasma antigens.