(a.) Globe-shaped; having the form of a ball or sphere; spherical, or nearly so; as, globular atoms.
Example Sentences:
(1) Electron microscopy revealed the presence of a hitherto unreported peculiar "pilovacuolar" inclusion in numerous mitochondria, composed of an electron dense pile or rod within a vacuole, while globular or crystalline inclusions were absent.
(2) Sedimentation-velocity experiments indicate the M. elsdenii enzyme (s20,w = 4.95 S) to be essentially globular, while the D. vulgaris enzyme (s20,w = 4.1 S) has a less symmetric shape.
(3) Both types of molecules are compact and globular in shape and apparently contain beta-pleated sheet conformation.
(4) The native mass of factor a was estimated to be 240-260 kDa by gel filtration, but its sedimentation rate in a glycerol gradient was similar to that of a much smaller globular protein, suggesting an extended conformation.
(5) In particular, nitration of Tyr-51 provoked a structural perturbation in the globular region.
(6) The globular cells appeared to receive numerous afferents with GABA- or glycine-like immunoreactivity on their somata.
(7) Although the globular bushy cell axons were not completely filled from the soma of origin to terminal fields in the contralateral brainstem, a number of consistent anatomical features were distinguished in the population.
(8) Sera reactive with this protein identify a distinctive globular nuclear antigen.
(9) Cells with demarcated borders showed rearrangement of microvilli into globular chains or ridges which lined up with the branching membrane.
(10) It is suggested that the neoplastic cells produced the fibronectin, which accumulated in globular form.
(11) 88, 543--555] have shown that these derivatives act as partial agonists at the platelet ADP receptor inducing only the transition from discoid to globular morphology ('shape change').
(12) Thereafter, 27S species adsorbed avidly to it and collapsed into characteristic configurations containing four globular domains, each linked to the others by three approximately 33-nm struts.
(13) Extensive surgical resections of neocortical cerebral tissue (including hemispherectomies) from 13 infants and children with infantile spasms showed that 12 of 13 specimens contained either malformative and dysplastic lesions of the cortex and white matter (sometimes with associated hamartomatous proliferation of globular cells), or destructive lesions possibly acquired as a result of anoxic-ischemic injury, or a combination of the two.
(14) In this more nearly globular shape, CAM reveals to the environment two interior pockets that contain a number of hydrophobic residues, in agreement with NMR data suggesting involvement of such residues in the binding of inhibitors and proteins to CAM.
(15) The abdomen was tender with guarding and a palpable globular mass in the same region.
(16) Examination of the SnF2-treated dentin surfaces showed a dense layer of globular particles and in addition some larger particles.
(17) They are calibrated or tested against a large body of experimental data, including extended basis set ab initio, quantum mechanical calculations, nuclear magnetic resonance spectroscopic data and dipole moment data for di- and oligopeptides, characteristic ratio data for random coil homopolypeptides, extensive data from peptide solubility studies, and experimental structures of polyalanine fibres and globular proteins.
(18) We have found that mycoplasma virus L172 is an enveloped globular virion containing circular, single-stranded DNA of 14.0 kilobases.
(19) Overlapping cDNA clones that span the entire length of the corresponding 7.2-kb mRNA reveal an encoded polypeptide of 236,278 D that is predicted to contain two globular domains separated by a discontinuous alpha-helix with characteristics for adopting a coiled-coil structure.
(20) The shape of the protein is approximately globular (S20.w = 4.18 S).
Globule
Definition:
(n.) A little globe; a small particle of matter, of a spherical form.
(n.) A minute spherical or rounded structure; as blood, lymph, and pus corpuscles, minute fungi, spores, etc.
(n.) A little pill or pellet used by homeopathists.
Example Sentences:
(1) The values obtained are shown to be lower than those calculated for arigid pepsin globule.
(2) Histologically, foci strongly resembling hepatocellular carcinoma with hyaline globules were noted.
(3) A large portion of the N-terminal globule of human collagen VI was prepared from the culture medium of stably transfected human embryonic kidney cell clones.
(4) Ultrastructurally, the globules measured 0.5-1.5 mu in diameter and they were usually not membrane bound.
(5) Calcification initially occurs in maxtrix vesicles (or calcifying globules) which are very numerous between the collagen fibrils of the osteoid tissue, and successively spreads into the surrounding interfibrillar matrix.
(6) This early rejection was associated with local appearance of globule leucocytes and increased concentration of T. colubriformis-specific IgG1 and IgG2 in intestinal mucus.
(7) Eosinophilic globules were found in 17% of the 34 nevi, and congenital features in 8.8%.
(8) In some areas, the tumor shows a striking resemblance to Kaposi's sarcoma; criss-crossing fascicles of spindle cells are interspersed with narrow vascular spaces, but PAS-positive hyaline globules are absent.
(9) Kamino's eosinophilic globules could be considered another important sign for the differential diagnosis between pigmented spindle cell nevus and malignant melanoma.
(10) Deposits of reaction product were found in varying amounts on the membranes of primary vesicles in the globules.
(11) Double immunofluorescence microscopy revealed that hsp70 codistributed with the c-myc protein in distinct globules in the nucleus of many but not all myc-positive cells.
(12) Lipids associated with fat globule membrane components increased during the dry period.
(13) Examination of possibility of AAT deficiency should be performed in every case, where the cause of liver disease is unsolved; this examination is especially indicated by the presence of typical PAS positive, diastase-resistant, AAT immunreactive globules in hepatocytes.
(14) In addition to exposing the underlying filamentous substructure of the matrix, protease treatment also revealed large, straight fiber bundles and globules of amorphous material suspended in the filamentous web.
(15) Cow, goat, and human globules were subjected to varying concentrations of the bile salt taurodeoxycholate at 37 degrees C for 2 min, and the released material was obtained by centrifugation at 2 degrees C and 50,000 g for 1 h. Sedimented pellets were analyzed for phospholipid and protein and were characterized further by sodium dodecylsulfate-polyacrylamide gel electrophoresis.
(16) The examination of the data leads to the conclusion on the existence of two possible mechanisms: the variation of properties of surface tryptophan residues environment and paramagnetic orientation of protein globule under the influence of a magnetic field.
(17) Myxoglobulosis is a rare morphologic variant of appendiceal mucocele characterized by intraluminal mucinous globules of the appendix.
(18) A remarkable array of filaments, approximately 0.5 micron in length, was seen on human, but not bovine, globules.
(19) In 10 of 56 patients with primary liver carcinoma the nontumorous hepatocytes contained diastase resistant, periodic acid-Schiff positive and alpha-1-antitrypsin positive (immunoperoxidase technique) globules.
(20) The antigenic relationship between the milk fat globule membrane (MFGM) and the hydrophobic fraction of proteose-peptone (HFPP) was demonstrated, using a mono-specific anti-HFPP antibody.