(a.) Globe-shaped; having the form of a ball or sphere; spherical, or nearly so; as, globular atoms.
Example Sentences:
(1) Electron microscopy revealed the presence of a hitherto unreported peculiar "pilovacuolar" inclusion in numerous mitochondria, composed of an electron dense pile or rod within a vacuole, while globular or crystalline inclusions were absent.
(2) Sedimentation-velocity experiments indicate the M. elsdenii enzyme (s20,w = 4.95 S) to be essentially globular, while the D. vulgaris enzyme (s20,w = 4.1 S) has a less symmetric shape.
(3) Both types of molecules are compact and globular in shape and apparently contain beta-pleated sheet conformation.
(4) The native mass of factor a was estimated to be 240-260 kDa by gel filtration, but its sedimentation rate in a glycerol gradient was similar to that of a much smaller globular protein, suggesting an extended conformation.
(5) In particular, nitration of Tyr-51 provoked a structural perturbation in the globular region.
(6) The globular cells appeared to receive numerous afferents with GABA- or glycine-like immunoreactivity on their somata.
(7) Although the globular bushy cell axons were not completely filled from the soma of origin to terminal fields in the contralateral brainstem, a number of consistent anatomical features were distinguished in the population.
(8) Sera reactive with this protein identify a distinctive globular nuclear antigen.
(9) Cells with demarcated borders showed rearrangement of microvilli into globular chains or ridges which lined up with the branching membrane.
(10) It is suggested that the neoplastic cells produced the fibronectin, which accumulated in globular form.
(11) 88, 543--555] have shown that these derivatives act as partial agonists at the platelet ADP receptor inducing only the transition from discoid to globular morphology ('shape change').
(12) Thereafter, 27S species adsorbed avidly to it and collapsed into characteristic configurations containing four globular domains, each linked to the others by three approximately 33-nm struts.
(13) Extensive surgical resections of neocortical cerebral tissue (including hemispherectomies) from 13 infants and children with infantile spasms showed that 12 of 13 specimens contained either malformative and dysplastic lesions of the cortex and white matter (sometimes with associated hamartomatous proliferation of globular cells), or destructive lesions possibly acquired as a result of anoxic-ischemic injury, or a combination of the two.
(14) In this more nearly globular shape, CAM reveals to the environment two interior pockets that contain a number of hydrophobic residues, in agreement with NMR data suggesting involvement of such residues in the binding of inhibitors and proteins to CAM.
(15) The abdomen was tender with guarding and a palpable globular mass in the same region.
(16) Examination of the SnF2-treated dentin surfaces showed a dense layer of globular particles and in addition some larger particles.
(17) They are calibrated or tested against a large body of experimental data, including extended basis set ab initio, quantum mechanical calculations, nuclear magnetic resonance spectroscopic data and dipole moment data for di- and oligopeptides, characteristic ratio data for random coil homopolypeptides, extensive data from peptide solubility studies, and experimental structures of polyalanine fibres and globular proteins.
(18) We have found that mycoplasma virus L172 is an enveloped globular virion containing circular, single-stranded DNA of 14.0 kilobases.
(19) Overlapping cDNA clones that span the entire length of the corresponding 7.2-kb mRNA reveal an encoded polypeptide of 236,278 D that is predicted to contain two globular domains separated by a discontinuous alpha-helix with characteristics for adopting a coiled-coil structure.
(20) The shape of the protein is approximately globular (S20.w = 4.18 S).
Zymogene
Definition:
(n.) One of a physiological group of globular bacteria which produces fermentations of diverse nature; -- distinguished from pathogene.
Example Sentences:
(1) The study confirms that secretin influences pancreatic protein secretion and indicates in addition, that pharmacologic doses of the hormone, have the capacity to block acinar cell zymogen granule release.
(2) The data indicate that collagenase is released from the cells in inactive form, as a zymogen.
(3) Thus it can be tentatively suggested that it is prokallikrein A which is secreted into the pancreatic juice and represents the physiologically important zymogen.
(4) The presence of acinar cells with zymogen granules, squamous metaplasia and endocrine components makes the diagnosis.
(5) The cDNA-inferred amino acid sequence of apo[a] indicates that apo[a], like plasminogen and some zymogens, is composed of a kringle domain and a serine protease domain.
(6) When aprotinin was added during the course of the purification, the major species isolated was the zymogen form (28,000 Da) of pump-1.
(7) At very low detergent concentrations, below the critical micelle concentration, the anionic sulfates induce protein aggregation such that phospholipase A2, as well as its zymogen, is present in high molecular weight complexes containing several protein molecules.
(8) We combined these changes with a genetically altered glycoform to generate a zymogen protein C with a 60-fold increased cleavage rate by free alpha-thrombin, independent of its cofactor thrombomodulin.
(9) During autoactivation in a cell-free system, the 55 and 53 kDa zymogens are sequentially converted into the 49, 36, 31 and 25 kDa forms.
(10) Human C'1, a macromolecular complex composed of three subunits, is the zymogen for at least two distinct enzymes.
(11) Combination therapy with E-3123 and CMZ showed significant protective effects against the high mortality rate, increased serum amylase and ascitic fluid amylase levels, pancreatic amylase and lysosomal enzyme content, plasma endotoxin levels, redistribution of lysosomal enzyme from the lysosomal to the zymogen fraction, lysosomal and mitochondrial fragility, and also improved the histological findings when compared with the E-3123 alone.
(12) The circulating zymogen form of thrombin, prothrombin, was converted to proteolytically active thrombin during incubation with ECM.
(13) In the three groups of animals, lipase antigenic sites were detected with high resolution in the acinar cells in the compartments involved in protein secretion: rough endoplasmic reticulum, Golgi apparatus, and secretory zymogen granules.
(14) The overall identity with other zymogens for gastric proteinases is 27%.
(15) The fusion of granules with plasma membranes was unaffected by variation of the Ca2+ concentration over a wide range, but fusion of granules with both plasma membranes and zymogen granule membranes was stimulated by GTP and, more potently, by guanosine 5'-[gamma-thio]triphosphate (GTP[S]).
(16) Notably, zymogen granule dissolution neither preceded nor accompanied this swelling, but developed pari passu with cell degradation.
(17) We found small amounts of lysosomal enzymes colocalized with digestive enzymes within zymogen granules in normal acinar cells and in normal pancreatic juice, suggesting some physiological roles of lysosomal enzymes in pancreatic ducts.
(18) Both tumor cells frequently contained well-developed RER, zymogen-like granules, and annulate lamellae.
(19) For the native zymogen the rate of this conversion had been shown to be identical to the rate of cleavage of the scissile bond of pepsinogen.
(20) Ala-neochymotrypsinogen was activated by incubating with trypsin at a zymogen : trypsin ratio of 30 : 1 in 0.1 M phosphate buffer, pH 7.6 at 4 degrees C for 1 h. The fully active, stable species was identified as alpha-chymotrypsin.