What's the difference between goldenseal and hydrastine?
Goldenseal
Definition:
Example Sentences:
Hydrastine
Definition:
(n.) An alkaloid, found in the rootstock of the golden seal (Hydrastis Canadensis), and extracted as a bitter, white, crystalline substance. It is used as a tonic and febrifuge.
Example Sentences:
(1) As an antagonist of the activation of low affinity GABAA receptors as measured by the stimulation by GABA of [3H]-diazepam binding to rat brain membranes, (+)-hydrastine (IC50 0.4 microM) was more potent than bicuculline (IC50 2.3 microM).
(2) Cysts from d-hydrastine treated mice were shown by transmission electron microscope to have dissolution of the microtriches, disturbance of organelles in their arrangement, dilatation and disruption of microtubules, increase in size and number of lysosomes, a decrease in number of Golgi complexes and lessening in density and swelling of mitochondria.
(3) (+)-Hydrastine, 10 nM to 1 mM, did not inhibit the binding of [3H]-(-)-baclofen to GABAB binding sites in rat brain membranes.
(4) When tested against the binding of [3H]-muscimol to high affinity GABAA binding sites in rat brain membranes, (+)-hydrastine (IC50 2.37 microM) was 8 times more potent than bicuculline (IC50 19.7 microM).
(5) (+)-Hydrastine is a phthalide isoquinoline alkaloid, isolated from Corydalis stricta.
(6) The present paper reports the protoscolicidal action of hydrastine, ether-acetic acid-ethanol admixture, H2O2, pyquiton and albendazole through in vitro or in vivo exposure, for 15 minutes and transplantation studies.
(7) The mortality of protoscolices in vitro and in vivo were 70.2% and 68.9% for 0.3% hydrastine, 56.8% and 56.2% for 10% ether-acetic acid-ethanol admixture, 6.0% and 8.8% for 0.3% H2O2; 6.1% for 0.004% pyquiton in vitro and 5.0% were 10% and 25% for 0.3% hydrastine, 30% and for 0.004% albendazole in vitro.
(8) Hydrastine and strychnine produced an increase in non-adrenergic IPSPs of smooth muscle cells.
(9) It has the same 1S,9R configuration as the competitive GABAA receptor antagonist bicuculline and is the enantiomer of the commercially available (-)-hydrastine.
(10) (+)-Hydrastine was a competitive antagonist of GABAA responses (pA2 6.5) more potent than bicuculline (pA2 6.1).
(11) Disruption of external plasma membrane, hook detachment, sucker deformity of protoscolices exposed to hydrastine were demonstrated by scanning electron microscopy.
(12) Some structurally related compounds with antitussive properties (narceine, hydrastine, narcotoline and papaverine) were potent competitors, while other antitussives did not inhibit [3H]noscapine binding.
(13) The effects of strychnine, hydrastine and apamine on nervemuscle transmission in guinea pig stomach and taenia coli were studied.
(14) The above effects were completely reproduced by the bicuculline related-substance, beta-hydrastine, but not by the bicuculline N-methyl derivative, bicuculline methiodide (BMI), on the isolated rat atria.
(15) (+)-Hydrastine was a selective antagonist at bicuculline-sensitive GABAA receptors in the guinea-pig isolated ileum.
(16) It is suggested that hydrastine exerts a profound intracellular effect on the protoscolex of E. granulosus of sheep and man, and might be a promising protoscolicide as adjuvant to hydatid surgery.
(17) This action was stereoselective in that (+)-hydrastine was 180 times as potent as (-)-hydrastine.
(18) It seems that d-hydrastine has a profound intracellular effect on experimental Echinococcus granulosus cysts in mice, and that it may be a promising drug for treating hydatidosis.