(1) Although GORD is primarily a motor disorder, the injurious effects of gastric acid are central to the pathogenic process of oesophagitis, and the severity of disease correlates with the degree and duration of oesophageal acid exposure.
(2) The ambulatory 24 hour pH test may have rendered the AP test obsolete in the assessment of GORD as the cause of NCCP.
(3) Epidemiological studies of gastro-oesophageal reflux disease (GORD) are confounded by the lack of a standardized definition and a diagnostic 'gold-standard' for the disorder.
(4) Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients.
(5) This may be made worse by relative gastric acid hypersecretion in some patients with severe GORD.
(6) The aim of this study was to investigate the association of gastro-oesophageal reflux disease (GORD) with radiographic pulmonary changes.
(7) The pathogenesis of GORD depends on a mix of factors which vary amongst individual patients.
(8) In the NCCP population with a normal oesophageal examination (1) AP test reproduction of chest pain is poorly predictive of GORD; (2) AP test reproduction of heartburn is more predictive of GORD but does not ensure that the chest pain is caused by GORD; (3) a negative AP test does not exclude GORD and (4) only 48% of AP test positive patients have demonstrable acid mediated chest pain.
(9) Although these data are not conclusive, it seems prudent, if possible, to avoid the use of NSAIDs in patients with GORD, particularly those with oesophageal stricture.
(10) In patients with more severe grades of oesophagitis, there are abnormally high levels of nocturnal acid exposure, with the intra-oesophageal pH being less than 4.0 for 36% of the time, compared with 5% of the time in patients with mild GORD.
(11) In Western countries, 20-40% of the adult population experience heartburn, which is the cardinal symptom of GORD, but only some 2% of adults have objective evidence of reflux oesophagitis.
(12) Of patients with oesophagitis 29% had no typical symptoms of GORD; only 24% of patients with regurgitation had oesophagitis.
(13) Although GORD causes substantial morbidity, the annual mortality rate due to GORD is very low (approximately 1 death per 100,000 patients), and even severe GORD has no apparent effect on longevity, although the quality of life can be significantly impaired.
(14) A third of the patients reported such inconclusive symptomatology at history-taking that no preliminary diagnosis about the presence or absence of GORD could be made.
(15) The limited information available about salivation in GORD patients suggests that salivary secretion is no different from that of age-matched controls, but that there is an age-dependent loss of the salivary response to oesophageal acidification.
(16) The long duration of action and effective inhibition of meal-stimulated acid secretion probably explains the superiority of omeprazole in treating GORD.
(17) In the 105 of these patients in whom there was any suspicion of GORD, 24-hour pH monitoring was carried out.
(18) When patients were divided according to their symptoms suggestive of GORD, lower VC%, FVC%, and FEV1% were found in patients with than in those without symptoms (87 vs 102, p = 0.0018; 76 vs 91, p = 0.0099; 80 vs 93, p = 0.0026).
(19) The signs and symptoms of GORD often wax and wane in intensity, and spontaneous remissions have been reported.
(20) Of several symptoms thought to be related to gastrooesophageal reflux disease (GORD), only heartburn (68% vs 48%) and acid regurgitation (60% vs 48%) occurred in more of the patients with GORD (as determined by pH monitoring) than of those with normal pH monitoring.
Gorm
Definition:
(n.) Axle grease. See Gome.
(v. t.) To daub, as the hands or clothing, with gorm; to daub with anything sticky.
Example Sentences:
(1) Asked by counsel assisting the inquest Jeremy Gormly SC whether it was the case that it was not going to be available to any of the three snipers to take a shot unless the glass was breached, he replied: “I believe that to be correct.” Sydney siege: plan to release hostage thwarted by mass breakout, inquest told Read more The officer, who cannot be identified for legal reasons, has also rejected suggestions that the sniper at the Westpac building could have taken a shot at Monis at about 7.38pm, when the gunman was observed through a window at the Lindt cafe.
(2) Overseen by New South Wales coroner Michael Barnes, the inquest is being guided by Jeremy Gormly SC, counsel assisting the coroner, who has revealed there are many audio and video recordings from inside the cafe to shed more light on what happened.
(3) Rothman shows more gorm: sometimes chaos is just chaos.
(4) Sydney siege: how a day and night of terror unfolded at the Lindt cafe Read more Asked by counsel assisting the coroner, Jeremy Gormly SC, what he believed Monis was referring to, Morton-Hoffman said: “I believe Monis might have said to me that he wants, he has these two bombs on him but he doesn’t want to blow them up and he needs the police to disarm them ... take them out of the building so that we don’t die.” It was confirmed after the siege ended there were no bombs.
(5) When pressed by counsel assisting the inquest, Jeremy Gormly SC, why the emergency action trigger had not been reached despite a shot being fired, the tactical commander said no hostage had been harmed at that stage.