(1) Although GORD is primarily a motor disorder, the injurious effects of gastric acid are central to the pathogenic process of oesophagitis, and the severity of disease correlates with the degree and duration of oesophageal acid exposure.
(2) The ambulatory 24 hour pH test may have rendered the AP test obsolete in the assessment of GORD as the cause of NCCP.
(3) Epidemiological studies of gastro-oesophageal reflux disease (GORD) are confounded by the lack of a standardized definition and a diagnostic 'gold-standard' for the disorder.
(4) Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients.
(5) This may be made worse by relative gastric acid hypersecretion in some patients with severe GORD.
(6) The aim of this study was to investigate the association of gastro-oesophageal reflux disease (GORD) with radiographic pulmonary changes.
(7) The pathogenesis of GORD depends on a mix of factors which vary amongst individual patients.
(8) In the NCCP population with a normal oesophageal examination (1) AP test reproduction of chest pain is poorly predictive of GORD; (2) AP test reproduction of heartburn is more predictive of GORD but does not ensure that the chest pain is caused by GORD; (3) a negative AP test does not exclude GORD and (4) only 48% of AP test positive patients have demonstrable acid mediated chest pain.
(9) Although these data are not conclusive, it seems prudent, if possible, to avoid the use of NSAIDs in patients with GORD, particularly those with oesophageal stricture.
(10) In patients with more severe grades of oesophagitis, there are abnormally high levels of nocturnal acid exposure, with the intra-oesophageal pH being less than 4.0 for 36% of the time, compared with 5% of the time in patients with mild GORD.
(11) In Western countries, 20-40% of the adult population experience heartburn, which is the cardinal symptom of GORD, but only some 2% of adults have objective evidence of reflux oesophagitis.
(12) Of patients with oesophagitis 29% had no typical symptoms of GORD; only 24% of patients with regurgitation had oesophagitis.
(13) Although GORD causes substantial morbidity, the annual mortality rate due to GORD is very low (approximately 1 death per 100,000 patients), and even severe GORD has no apparent effect on longevity, although the quality of life can be significantly impaired.
(14) A third of the patients reported such inconclusive symptomatology at history-taking that no preliminary diagnosis about the presence or absence of GORD could be made.
(15) The limited information available about salivation in GORD patients suggests that salivary secretion is no different from that of age-matched controls, but that there is an age-dependent loss of the salivary response to oesophageal acidification.
(16) The long duration of action and effective inhibition of meal-stimulated acid secretion probably explains the superiority of omeprazole in treating GORD.
(17) In the 105 of these patients in whom there was any suspicion of GORD, 24-hour pH monitoring was carried out.
(18) When patients were divided according to their symptoms suggestive of GORD, lower VC%, FVC%, and FEV1% were found in patients with than in those without symptoms (87 vs 102, p = 0.0018; 76 vs 91, p = 0.0099; 80 vs 93, p = 0.0026).
(19) The signs and symptoms of GORD often wax and wane in intensity, and spontaneous remissions have been reported.
(20) Of several symptoms thought to be related to gastrooesophageal reflux disease (GORD), only heartburn (68% vs 48%) and acid regurgitation (60% vs 48%) occurred in more of the patients with GORD (as determined by pH monitoring) than of those with normal pH monitoring.
Gourd
Definition:
(n.) A fleshy, three-celled, many-seeded fruit, as the melon, pumpkin, cucumber, etc., of the order Cucurbitaceae; and especially the bottle gourd (Lagenaria vulgaris) which occurs in a great variety of forms, and, when the interior part is removed, serves for bottles, dippers, cups, and other dishes.
(n.) A dipper or other vessel made from the shell of a gourd; hence, a drinking vessel; a bottle.
(n.) A false die. See Gord.
(n.) Alt. of Gourde
Example Sentences:
(1) Gourd seed inhibitors were purified in the following manner: gourd seeds were ground and extracted with 10 mM ammonium carbonate, pH 7.8.
(2) Three serine proteinase inhibitors, MCTI-I, MCTI-II, and MCEI-I, were isolated from bitter gourd (Momordica charantia LINN.)
(3) 1. beta-Momorcharin, a glycoprotein isolated from seeds of the bitter gourd, inhibited incorporation of [3H]leucine, [3H]uridine and [3H]thymidine into trichloroacetic acid-precipitable radioactivity in peri-implantation mouse embryos, mouse splenocytes with or without activation by concanavalin A, and human squamous carcinoma of the tongue and larynx, but did not affect incorporation of the aforementioned radioisotopes into mouse liver cells.
(4) Age composition, seasonal abundance and diel patterns of landing activity of the sylvan vector of yellow fever Haemagogus janthinomys Dyar were monitored weekly during 1981-82 by human collectors on the ground at Point Gourde in Chaguaramas Forest, 16 km west of Port of Spain, Trinidad.
(5) And, if one is not at the zenith of adulation of the Pacific islanders who believe the Prince to be the penis-gourd-sporting Melanesian Messiah, then, at the very least, the example of Britain's longest-serving monarchal consort is deserving of our – and, more specifically, the Duchess of Cambridge's – interest.
(6) Many had a longer cell body and were cylindrical or gourd-like in shape, but some short hair cells were also present in the caudal saccule.
(7) Seven trypsin inhibitors were isolated from the seeds of Cucurbitaceae plants: two from cucumber (Cucumis sativus) and red bryony (Bryonia diotica) and one from figleaf gourd (Cucurbita ficifolia), spaghetti squash (Cucurbita pepo var.
(8) She spent an hour preparing a huge spread of dishes, using her own curry powder: jackfruit curry, crispy chewy aubergine, bitter gourd salad, fish balls, mango chutney and ambulthiyal – chunks of yellowfin tuna steeped in spices.
(9) The complete amino acid sequence of ribonuclease (RNase MC) from the seeds of bitter gourd (Momordica charantia) has been determined.
(10) Three new proteins which inhibit protein synthesis in rabbit reticulocyte lysates were isolated from an extract of sponge gourd (Luffa cylindrica) seeds by chromatography on a AF-Blue Toyopearl column followed by FPLC with a Mono S column.
(11) Experimental evidence indicated that the snake-gourd proteinases are similar in their properties to cucumisin, which is isolated from the sarcocarp of melon fruit.
(12) Correlations between ragweed and gourd-specific IgE levels were significant (p less than 0.001), and correlation coefficients between any two gourds exceeded 0.79.
(13) Gourde Forest, Trinidad, were monitored weekly for 53 consecutive weeks using conventional ovitraps.
(14) Luffin-a, a ribosome-inactivating protein from the seeds of sponge gourd (Luffa cylindrica), was modified with 2,4,6-trinitrobenzenesulfonic acid (TNBS) at pH 8.0 and 20 degrees C. The inhibitory activity of the modified luffin-a on protein synthesis using rabbit reticulocyte lysate was lost rapidly at a rate compatible with that of the modification of a single highly reactive amino group in the initial stage of the reaction.
(15) Urinary tract roentgenograms show a high, gourd-shaped bladder with the surrounding radiolucency of fatty tissues.
(16) Southern hybridization studies using french bean highly repetitive DNA as a probe indicated more homology with repeats of pigeon pea and less homology with red gourd, snake gourd and cucumber repeats.
(17) A galactose binding lectin was isolated from the seeds of the bitter gourd Momordica charantia by delipidation with petroleum ether, extraction with phosphate buffered saline, ammonium sulfate precipitation and affinity chromatography on lactogel.
(18) Digestion of nuclear DNAs of five plants, namely Cucurbita maxima (red gourd), Trichosanthes anguina (snake gourd), Cucumis sativus (cucumber), Cajanus cajan (pigeon pea) and Phaseolus vulgaris (french bean) with the restriction endonuclease MboI yielded discrete size classes with molecular weights in the range of 0.5 to 5 kbp.
(19) A lectin specific for chito-oligosaccharides from the exudate of ridge gourd (Luffa acutangula) fruits has been purified to homogeneity by affinity chromatography.
(20) And in one corner of the garden, a group of nondescript lidded boxes contains a project for the future: the Garden of Bangladesh, an exercise in growing the ingredients used in Bangladeshi cooking, such as gourds and coriander, suggested by some of the Bangladeshis who work in the store.