(1) Although GORD is primarily a motor disorder, the injurious effects of gastric acid are central to the pathogenic process of oesophagitis, and the severity of disease correlates with the degree and duration of oesophageal acid exposure.
(2) The ambulatory 24 hour pH test may have rendered the AP test obsolete in the assessment of GORD as the cause of NCCP.
(3) Epidemiological studies of gastro-oesophageal reflux disease (GORD) are confounded by the lack of a standardized definition and a diagnostic 'gold-standard' for the disorder.
(4) Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients.
(5) This may be made worse by relative gastric acid hypersecretion in some patients with severe GORD.
(6) The aim of this study was to investigate the association of gastro-oesophageal reflux disease (GORD) with radiographic pulmonary changes.
(7) The pathogenesis of GORD depends on a mix of factors which vary amongst individual patients.
(8) In the NCCP population with a normal oesophageal examination (1) AP test reproduction of chest pain is poorly predictive of GORD; (2) AP test reproduction of heartburn is more predictive of GORD but does not ensure that the chest pain is caused by GORD; (3) a negative AP test does not exclude GORD and (4) only 48% of AP test positive patients have demonstrable acid mediated chest pain.
(9) Although these data are not conclusive, it seems prudent, if possible, to avoid the use of NSAIDs in patients with GORD, particularly those with oesophageal stricture.
(10) In patients with more severe grades of oesophagitis, there are abnormally high levels of nocturnal acid exposure, with the intra-oesophageal pH being less than 4.0 for 36% of the time, compared with 5% of the time in patients with mild GORD.
(11) In Western countries, 20-40% of the adult population experience heartburn, which is the cardinal symptom of GORD, but only some 2% of adults have objective evidence of reflux oesophagitis.
(12) Of patients with oesophagitis 29% had no typical symptoms of GORD; only 24% of patients with regurgitation had oesophagitis.
(13) Although GORD causes substantial morbidity, the annual mortality rate due to GORD is very low (approximately 1 death per 100,000 patients), and even severe GORD has no apparent effect on longevity, although the quality of life can be significantly impaired.
(14) A third of the patients reported such inconclusive symptomatology at history-taking that no preliminary diagnosis about the presence or absence of GORD could be made.
(15) The limited information available about salivation in GORD patients suggests that salivary secretion is no different from that of age-matched controls, but that there is an age-dependent loss of the salivary response to oesophageal acidification.
(16) The long duration of action and effective inhibition of meal-stimulated acid secretion probably explains the superiority of omeprazole in treating GORD.
(17) In the 105 of these patients in whom there was any suspicion of GORD, 24-hour pH monitoring was carried out.
(18) When patients were divided according to their symptoms suggestive of GORD, lower VC%, FVC%, and FEV1% were found in patients with than in those without symptoms (87 vs 102, p = 0.0018; 76 vs 91, p = 0.0099; 80 vs 93, p = 0.0026).
(19) The signs and symptoms of GORD often wax and wane in intensity, and spontaneous remissions have been reported.
(20) Of several symptoms thought to be related to gastrooesophageal reflux disease (GORD), only heartburn (68% vs 48%) and acid regurgitation (60% vs 48%) occurred in more of the patients with GORD (as determined by pH monitoring) than of those with normal pH monitoring.
Indigestion
Definition:
(n.) Lack of proper digestive action; a failure of the normal changes which food should undergo in the alimentary canal; dyspepsia; incomplete or difficult digestion.
Example Sentences:
(1) Duodenal DM flow was estimated with the indigestible markers, Cr-mordanted cell wall, Yb-soaked whole crop oat silage, and Co-EDTA.
(2) Our results demonstrate that in both diabetics and in controls the gastric emptying of digestible and indigestible solids occurs during the same phase of gastric motor activity, i.e.
(3) The symptoms of anaemia and indigestion appear to be paramount in making an early diagnosis, and negative barium meal studies should not be accepted when these two symptoms are present.
(4) Two dairy cows fitted with rumen cannulas and closed T-shaped duodenal cannulas were utilized to examine duodenal cannula function and indigestible marker performance.
(5) The parenchyma located close to the sclerenchyma became indigestible as the cell walls lignified progressively from the third stage.
(6) The objectives of the present study were to evaluate gastric and small bowel transit times of an indigestible solid matrix and to characterize the specific changes in intraluminal pH as a function of transit time through the gastrointestinal tract.
(7) Until recently these labels consisted of biologically indigestible carbohydrates attached to a radioactive reporter molecule.
(8) In 23 cows suffering from a secondary indigestion, in most cases with septicaemia, the syndrome of functional pyloric stenosis or vagal indigestion developed.
(9) Increased secretion of type 2 alveolocytes as well as participation of type 1 alveolocytes and macrophages in surfactant secretion were established in the course of intratracheal administration of indigestible mineral particles--natural zeolites to white male rats.
(10) The most common approach was an in-house medical kit with instructions emphasizing self treatment of the common ailments of travellers such as motion sickness, sleeplessness, diarrhoea, indigestion and headaches.
(11) Man, when acting in the role of the final host, often exhibits severe symptoms of indigestion.
(12) Electron-microscopic studies illustrate that the indigestible residue still has a preserved membrane structure.
(13) Dietary fiber is a highly interacting dietary component and is made up of a wide variety of enzyme-indigestible polymers: cellulose, pectins, gums, mucilages, lignin, and water-insoluble hemicelluloses.
(14) The effects of manipulation of the quantity and quality of protein, fat, and indigestible residues (fiber) of the diet will be described together with their possible implications for toxicity of ingested compounds.
(15) The Heidelberg capsule is an indigestible indicator of gastrointestinal pH, which was used to evaluate the relationship between gastric residence time (GRT) and variability in aspirin absorption from enteric-coated tablets.
(16) But when Ensler began passing blood five years ago, and her stomach distended, and she suffered terrible indigestion, and felt nauseous, she decided not to pay attention.
(17) This is a better survival rate than that reported for other causes of vagal indigestion.
(18) As compared with younger Rs, older respondents perceived intestinal flu to be relatively less serious-but earache, sprained toe, indigestion, having a tooth filled, stiff neck, and hangover to be relatively more serious.
(19) Surgery of the forestomach compartments is performed in bovine practices for the diagnosis and treatment of many diseases, including traumatic reticuloperitonitis, perireticular abscess, vagal indigestion, and grain overload.
(20) Spot samples of digesta were collected from duodenum and ileum during 96 h, and lanthanum was an indigestible marker to estimate flow and digestibility of nutrients.