(1) Although GORD is primarily a motor disorder, the injurious effects of gastric acid are central to the pathogenic process of oesophagitis, and the severity of disease correlates with the degree and duration of oesophageal acid exposure.
(2) The ambulatory 24 hour pH test may have rendered the AP test obsolete in the assessment of GORD as the cause of NCCP.
(3) Epidemiological studies of gastro-oesophageal reflux disease (GORD) are confounded by the lack of a standardized definition and a diagnostic 'gold-standard' for the disorder.
(4) Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients.
(5) This may be made worse by relative gastric acid hypersecretion in some patients with severe GORD.
(6) The aim of this study was to investigate the association of gastro-oesophageal reflux disease (GORD) with radiographic pulmonary changes.
(7) The pathogenesis of GORD depends on a mix of factors which vary amongst individual patients.
(8) In the NCCP population with a normal oesophageal examination (1) AP test reproduction of chest pain is poorly predictive of GORD; (2) AP test reproduction of heartburn is more predictive of GORD but does not ensure that the chest pain is caused by GORD; (3) a negative AP test does not exclude GORD and (4) only 48% of AP test positive patients have demonstrable acid mediated chest pain.
(9) Although these data are not conclusive, it seems prudent, if possible, to avoid the use of NSAIDs in patients with GORD, particularly those with oesophageal stricture.
(10) In patients with more severe grades of oesophagitis, there are abnormally high levels of nocturnal acid exposure, with the intra-oesophageal pH being less than 4.0 for 36% of the time, compared with 5% of the time in patients with mild GORD.
(11) In Western countries, 20-40% of the adult population experience heartburn, which is the cardinal symptom of GORD, but only some 2% of adults have objective evidence of reflux oesophagitis.
(12) Of patients with oesophagitis 29% had no typical symptoms of GORD; only 24% of patients with regurgitation had oesophagitis.
(13) Although GORD causes substantial morbidity, the annual mortality rate due to GORD is very low (approximately 1 death per 100,000 patients), and even severe GORD has no apparent effect on longevity, although the quality of life can be significantly impaired.
(14) A third of the patients reported such inconclusive symptomatology at history-taking that no preliminary diagnosis about the presence or absence of GORD could be made.
(15) The limited information available about salivation in GORD patients suggests that salivary secretion is no different from that of age-matched controls, but that there is an age-dependent loss of the salivary response to oesophageal acidification.
(16) The long duration of action and effective inhibition of meal-stimulated acid secretion probably explains the superiority of omeprazole in treating GORD.
(17) In the 105 of these patients in whom there was any suspicion of GORD, 24-hour pH monitoring was carried out.
(18) When patients were divided according to their symptoms suggestive of GORD, lower VC%, FVC%, and FEV1% were found in patients with than in those without symptoms (87 vs 102, p = 0.0018; 76 vs 91, p = 0.0099; 80 vs 93, p = 0.0026).
(19) The signs and symptoms of GORD often wax and wane in intensity, and spontaneous remissions have been reported.
(20) Of several symptoms thought to be related to gastrooesophageal reflux disease (GORD), only heartburn (68% vs 48%) and acid regurgitation (60% vs 48%) occurred in more of the patients with GORD (as determined by pH monitoring) than of those with normal pH monitoring.
John
Definition:
(n.) A proper name of a man.
Example Sentences:
(1) The judge, Mr Justice John Royce, told George she was "cold" and "calculating", as further disturbing details of her relationship with the co-accused, Colin Blanchard and Angela Allen, emerged.
(2) Names, and the absence of them, could be important Facebook Twitter Pinterest Don’t look back … Daisy Ridley’s Rey and John Boyega’s stormtrooper Finn.
(3) A new propaganda video by Islamic State featuring the British photojournalist John Cantlie, in which he says it is the “last film in this series”, has appeared online.
(4) The company, part of the John Lewis Partnership, now sources all its beef from the UK, including in its ready meals, sandwiches and fresh mince.
(5) It is a moment to be grateful for what remains of Labour's hard left: an amendment to scrap the cap was at least tabled by John McDonnell and Jeremy Corbyn but stood no chance.
(6) John Lewis’s marketing, advertising and reputation are all built on their promises of good customer services, and it is a large part of what still drives people to their stores despite cheaper online outlets.
(7) "In my era, we'd get a phone call from John [Galliano] before the show: this is what the show's about, what do you think?
(8) Two lunches are recoded with John Yates and Andy Hayman, the former assistant commissioners.
(9) The others were two Britons, Mark Cox and John Barrett (now both BBC commentators) and the US player Jim McManus.
(10) John Large, a leading nuclear consultant, said: "The HSE as an independent agency will come under tremendous pressure to push through these designs.
(11) The committee is chaired by John Thompson, the board's lead independent director, and includes Microsoft founder and chairman, Bill Gates, as well as other board members Chuck Noski and Steve Luczo.
(12) It is the biggest privatisation since John Major sold the railways in the 1990s.
(13) John Carver witnessed signs of much-needed improvement from the visitors in a purposeful spell either side of the interval but it was not enough to prevent a fifth successive Premier League defeat.
(14) An untiring advocate of the joys and merits of his adopted home county, Bradbury figured Norfolk as a place of writing parsons, farmer-writers and sensitive poets: John Skelton, Rider Haggard, John Middleton Murry, William Cowper, George MacBeth, George Szirtes.
(15) Facebook Twitter Pinterest Whether Sia, Jason Derulo, Coldplay’s Chris Martin or Sir Elton John is in the passenger seat, Corden plays the part of a real fan with a deep knowledge of their discography.
(16) The police investigating the 1991 murder of the Oxford student Rachel McLean had a strong hunch that the killer was her boyfriend, John Tanner, another student.
(17) Facebook Twitter Pinterest Imogen and her father, John Hull, before he lost his sight.
(18) It also devalues the courage of real whistleblowers who have used proper channels to hold our government accountable.” McCain added: “It is a sad, yet perhaps fitting commentary on President Obama’s failed national security policies that he would commute the sentence of an individual that endangered the lives of American troops, diplomats, and intelligence sources by leaking hundreds of thousands of sensitive government documents to WikiLeaks, a virulently anti-American organisation that was a tool of Russia’s recent interference in our elections.” WikiLeaks last year published emails hacked from the accounts of the Democratic National Committee and John Podesta, chairman of Hillary Clinton’s election campaign.
(19) The day it opened in the US, three senators – senate select committee on intelligence chairwoman Dianne Feinstein, Carl Levin and John McCain – released a letter of protest to Sony Pictures's CEO, citing their committee's 6,000-page classified report on interrogation tactics and calling on him "to state that the role of torture in the hunt for Osama bin Laden is not based on the facts, but rather part of the film's fictional narrative".
(20) Delabole residents Susan and John Theobald said: “We’ve always enjoyed being around the turbines and have often walked right up to them with our dogs.