(superl.) Large in space; of much size; big; immense; enormous; expanded; -- opposed to small and little; as, a great house, ship, farm, plain, distance, length.
(superl.) Large in number; numerous; as, a great company, multitude, series, etc.
(superl.) Long continued; lengthened in duration; prolonged in time; as, a great while; a great interval.
(superl.) Superior; admirable; commanding; -- applied to thoughts, actions, and feelings.
(superl.) Endowed with extraordinary powers; uncommonly gifted; able to accomplish vast results; strong; powerful; mighty; noble; as, a great hero, scholar, genius, philosopher, etc.
(superl.) Holding a chief position; elevated: lofty: eminent; distingushed; foremost; principal; as, great men; the great seal; the great marshal, etc.
(superl.) Entitled to earnest consideration; weighty; important; as, a great argument, truth, or principle.
(superl.) Pregnant; big (with young).
(superl.) More than ordinary in degree; very considerable in degree; as, to use great caution; to be in great pain.
(superl.) Older, younger, or more remote, by single generation; -- often used before grand to indicate one degree more remote in the direct line of descent; as, great-grandfather (a grandfather's or a grandmother's father), great-grandson, etc.
(n.) The whole; the gross; as, a contract to build a ship by the great.
Example Sentences:
(1) Arterial compliance of great vessels can be studied through the Doppler evaluation of pulsed wave velocity along the arterial tree.
(2) Both apertures were repaired with great caution using individual sutures without resection of the hernial sac.
(3) However, ticks, which failed to finish their feeding and represent a disproportionately great part of the whole parasite's population, die together with them and the parasitic system quickly restores its stability.
(4) To be fair to lads who find themselves just a bus ride from Auschwitz, a visit to the camp is now considered by many tourists to be a Holocaust "bucket list item", up there with the Anne Frank museum, where Justin Bieber recently delivered this compliment : "Anne was a great girl.
(5) Subtypes of HBs Ag are already of great use in the epidemiology of hepatitis B virus infections; yet they may have additional significance.
(6) Until the 1960's there was great confusion, both within and between countries, on the meaning of diagnostic terms such as emphysema, asthma, and chronic brochitis.
(7) For viewers in the US, you get the worst possible in-game managerial interview in Mike Matheny, one that's so bad, it's actually great!
(8) When compared with lissencephalic species, a great horizontal fibrillary system (which is vertically arranged in gyral regions) was observed in convoluted brains.
(9) DI James Faulkner of Great Manchester police said: “The men and women working in the factory have told us that they were subjected to physical and verbal assaults at the hands of their employers and forced to work more than 80-hours before ending up with around £25 for their week’s work.
(10) Nucleotide, which is essential for catalysis, greatly enhances the binding of IpOHA by the reductoisomerase, with NADPH (normally present during the enzyme's rearrangement step, i.e., conversion of a beta-keto acid into an alpha-keto acid, in either the forward or reverse physiological reactions) being more effective than NADP.
(11) Over the past decade the use of monoclonal antibodies has greatly advanced our knowledge of the biological properties and heterogeneity that exist within human tumours, and in particular in lung cancer.
(12) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(13) It’s great to observe the beach from that perspective.
(14) The dose response effect in this tumor is steep and combinations which compromise the dose of adriamycin too greatly are showing inferior results.
(15) Although the relative contributions of different fuels varies greatly in different organisms, in none is there a simple reliance on stored ATP.
(16) = 19) with a very low, but statistically significant, correlation with the AUC, r = 0.35 (p less than 0.05), thus demonstrating a very great individual variation in sensitivity to cimetidine.
(17) The popularly used procedure in Great Britain is that in which a sheet of Ivalon sponge is sutured to the sacrum and wrapped around the rectum thus anchoring it in place.
(18) Transfection of the treated DNA into SOS-induced spheroplasts results in an increase in mutagenesis as great as 50-fold.
(19) From the social economic point of view nosocomial infections represent a very important cost factor, which could be reduced to great deal by activities for prevention of nosocomial infection.
(20) We conclude that inflammatory lesions at these sites are not uncommon and that CT scans are diagnostic in the great majority.
Molecule
Definition:
(n.) One of the very small invisible particles of which all matter is supposed to consist.
(n.) The smallest part of any substance which possesses the characteristic properties and qualities of that substance, and which can exist alone in a free state.
(n.) A group of atoms so united and combined by chemical affinity that they form a complete, integrated whole, being the smallest portion of any particular compound that can exist in a free state; as, a molecule of water consists of two atoms of hydrogen and one of oxygen. Cf. Atom.
Example Sentences:
(1) A series of human cDNA clones of various sizes and relative localizations to the mRNA molecule were isolated by using the human p53-H14 (2.35-kilobase) cDNA probe which we previously cloned.
(2) Glucocorticoids have numerous effects some of which are permissive; steroids are thus important not only for what they do, but also for what they permit or enable other hormones and signal molecules to do.
(3) The results demonstrated that K2PtCl4 was bound to a greater degree than CDDP in this system with 3-5 and 1-2 platinum atoms respectively, bound per transferrin molecule.
(4) Complementarity determining regions (CDR) are conserved to different extents, with the first CDR region in all family members being among the most conserved segments of the molecule.
(5) Even with hepatic lipase, phospholipid hydrolysis could not deplete VLDL and IDL of sufficient phospholipid molecules to account for the loss of surface phospholipid that accompanies triacylglycerol hydrolysis and decreasing core volume as LDL is formed (or for conversion of HDL2 to HDL3).
(6) However, the presence of these two molecules was restored if testosterone was supplemented immediately after orchiectomy.
(7) In the second approach, attachment sites of DTPA groups were directed away from the active region of the molecule by having fragment E1,2 bound in complex, with its active sites protected during the derivatization.
(8) PMNs could be primed for PMA-triggered oxidative burst by muramyl peptide molecules (MDP) and two of its adjuvant active nonpyrogenic derivatives.
(9) These same molecules may be equally responsible for the pathologic characteristics of the immune response seen, for example, in inflammatory bowel diseases.
(10) A cDNA library prepared from human placenta has been screened for sequences coding for factor XIIIa, the enzymatically active subunit of the factor XIII complex that stabilizes blood clots through crosslinking of fibrin molecules.
(11) T cell costimulation by molecules on the antigen presenting cell (APC) is required for optimal T cell proliferation.
(12) The lipid A moiety was shown to be responsible for this novel biological activity of the LPS molecule.
(13) Both systems indicated that the Kupffer cell modified endotoxin by enriching the lipid content of the molecule and shortening the length of the O-antigen.
(14) Photoreactions induced in that proper sensitizer molecules absorb UV-light or visible light.
(15) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(16) Flow cytofluorometric analysis of the strain distribution of the molecules defined by the mAb revealed that two of the antibodies (I-22 and III-5) were directed against nonpolymorphic determinants of Thy-1, whereas V-8 mAb reacted only with Thy-1.2+ lymphocytes.
(17) At a fixed concentration of nucleotide the effectiveness of elution was proportional to the charge on the eluting molecule.
(18) The relative rates of reduction of several spin-labeled molecules that partition differently across the hy-drophobic-interface of inner membranes from rat liver mitochondria were investigated.
(19) The seve polypeptide chains investigated had generalyy similar properties; all contained two residues per molecule of tryptophan and N-acetylserine was the common N-terminal amino acid residue.
(20) Much information has accumulated on the isolation and characterization of a heterogeneous group of molecules that inhibit one or more of the bioactivities of interleukin 1.