(n.) The act of forming a groove or grooves; a groove, or collection of grooves.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Rifling
Definition:
(p. pr. & vb. n.) of Rifle
(n.) The act or process of making the grooves in a rifled cannon or gun barrel.
(n.) The system of grooves in a rifled gun barrel or cannon.
Example Sentences:
(1) He's Billy no-mates with a Heckler & Koch sniper-rifle, drowning in loneliness, booze and depression.
(2) A tall young Border Police officer stopped me, his rifle cradled in his arms.
(3) Types of weapons involved included handguns (48%), shotguns (22%), rifles (17%), unspecified weapon (12%), and air rifle (1%).
(4) Snipers fired from rooftops, and plainclothes Saleh supporters armed with automatic rifles, swords and batons attacked the protesters.
(5) Sky News has apologised profusely after one of its presenters was shown rifling through the personal belongings of a stricken passenger at the MH17 crash site.
(6) Deaths due to air rifles are extremely rare; only four other cases were found in the recent English-language literature.
(8) The drug was administered from a distance by means of a projectile syringe shot from a special rifle.
(9) We sampled a sawn-off shotgun and an assault rifle, but cops do get tasers and tear gas to add some urban flavour.
(10) Armed with an assault rifle, he then allegedly headed into two poor villages in Kandahar province, the Taliban's heartland, and went on a murderous rampage in which six people were also injured.
(11) District head Baba Abba Hassan said most victims are children, women and elderly people who could not run fast enough when insurgents drove into Baga, firing rocket-propelled grenades and assault rifles on town residents.
(12) Officers took up positions on rooftops and along railroad tracks and scanned the terrain through rifle scopes and binoculars.
(13) That proposal, similar to a Senate measure backed by the National Rifle Association, would let the attorney general delay a gun purchase by a suspected terrorist for three days, and let law enforcement officials ask a judge to block the purchase altogether.
(14) It can also be seen as a comment on the NSA debate, with Samantha gleefully rifling through Theodore's emails.
(15) Two men in a car tried to drive into the parking lot, jumped out with automatic rifles.
(16) A Royal Military police officer who was attached to the Rifles regiment, Pritchard had been put on duty at an observation post in the Sangin area of Helmand province, where the Taliban had fought hard for control.
(17) And with every heartbeat the blood was pumping up in the air from my thigh.” A man pointed a rifle at his head and threatened to finish him off.
(18) Via al-Aan correspondent Jenan Moussa: Jenan Moussa (@jenanmoussa) I asked a rebel sniper in #Syria : Drop ur rifle for a day & document life through lens of a camera.
(19) Heller called Bundy’s militia supporters, many of whom had trained semi-automatic rifles on government rangers during the stand-off, “patriots”; now his spokesman is saying that the senator “completely disagrees with Mr Bundy’s appalling and racist statements”.
(20) ", but nothing helped, there was so much other noise – both the helicopter above us and the bastard's rifle.