(v. t.) To touch; to feel with the hand; to use or hold with the hand.
(v. t.) To manage in using, as a spade or a musket; to wield; often, to manage skillfully.
(v. t.) To accustom to the hand; to work upon, or take care of, with the hands.
(v. t.) To receive and transfer; to have pass through one's hands; hence, to buy and sell; as, a merchant handles a variety of goods, or a large stock.
(v. t.) To deal with; to make a business of.
(v. t.) To treat; to use, well or ill.
(v. t.) To manage; to control; to practice skill upon.
(v. t.) To use or manage in writing or speaking; to treat, as a theme, an argument, or an objection.
(v. i.) To use the hands.
(n.) That part of vessels, instruments, etc., which is held in the hand when used or moved, as the haft of a sword, the knob of a door, the bail of a kettle, etc.
(n.) That of which use is made; the instrument for effecting a purpose; a tool.
Example Sentences:
(1) The high amino acid levels in the cells suggest that these cells act as inter-organ transporters and reservoirs of amino acids, they have a different role in their handling and metabolism from those of mammals.
(2) The most successful dyes were phenocyanin TC, gallein, fluorone black, alizarin cyanin BB and alizarin blue S. Celestin blue B with an iron mordant is quite successful if properly handled to prevent gelling of solutions.
(3) "The Samaras government has proved to be dangerous; it cannot continue handling the country's fate."
(4) Control of cell calcium handling and transport may be abnormal in hypertension.
(5) Equal numbers of handled and unhandled puparia were planted out at different densities (1, 2, 4 or 8 per linear metre) in fifty-one natural puparial sites in four major vegetation types.
(6) Arrogant, narcissistic, egotistical, brilliant – all of that I can handle in Paul,” Levinson writes.
(7) Isolated renal tubules and renal clearance techniques were used to characterize the renal handling of 2-deoxy-D-galactose (2-d-Gal) by the winter flounder (Pseudopleuronectes americanus).
(8) In this study, we examined renal tubular cell handling of digoxin and ouabain using LLC-PK1 cells, a model of proximal renal tubular cells.
(9) Just before Christmas the independent Kerslake report severely criticised Birmingham city council for its dysfunctional politics and, in particular, its handling of the so-called Trojan Horse affair, in which school governors were said to have set out to bring about an Islamic agenda into the curriculum contents and the day-to-day running of some schools.
(10) The effects of insulin on the renal handling of sodium, potassium, calcium, and phosphate were studied in man while maintaining the blood glucose concentration at the fasting level by negative feedback servocontrol of a variable glucose infusion.
(11) The Nd-Yag-Laser seems to be a useful device in transsphenoidal surgery due to its potent coagulation effect and comfortable handling.
(12) Techniques are described for the special handling of these cells as well as suitable assay procedures.
(13) The decision of the editors to solicit a review for the Medical Progress series of this journal devoted to current concepts of the renal handling of salt and water is sound in that this important topic in kidney physiology has recently been the object of a number of new, exciting and, in some instances, quite unexpected insights into the mechanisms governing sodium excretion.
(14) Possible reasons for the previous discrepancies between direct and isotopic methods are discussed, as are the effects of protein binding, sample handling, and storage conditions on oxalate values in plasma.
(15) In addition to working with hist colleagues on general review and health-policy matters, he also handled issues related to the special needs of children and helped to get third-party benefit packages altered to better suit the treatment needs of children.
(16) Furthermore, this system can be satisfactory handled by technical personnel after short periods of training.
(17) The major difficulty encountered with the current technique is the danger of neurologic injury during the passage and handling of conventional wires, especially in extensive procedures.
(18) Both techniques are used by industry and regulatory agencies to monitor levels of fungal contamination at various stages of food handling, storing, processing and marketing.
(19) The particular advantage of the method described here is the ease with which the supernatants can be collected and transferred to counting vials with minimal handling of radioactive samples.
(20) The greatest care should be exercised by industry in handling tremolite or materials contaminated with it.
Splice
Definition:
(v. t.) To unite, as two ropes, or parts of a rope, by a particular manner of interweaving the strands, -- the union being between two ends, or between an end and the body of a rope.
(v. t.) To unite, as spars, timbers, rails, etc., by lapping the two ends together, or by applying a piece which laps upon the two ends, and then binding, or in any way making fast.
(v. t.) To unite in marrige.
(n.) A junction or joining made by splicing.
Example Sentences:
(1) It is argued that this process drove the evolution of present 5' and 3' splice sites from a subset of proto-splice sites and also drove the evolution of a more efficient splicing machinery.
(3) One splicing mutation results in a 3 amino acid in-frame insertion.
(4) Each of the two spliced molecules contains a 5'-terminal leader sequence transcribed from a DNA segment with an estimated length of 60 to 110 nuvleotides.
(5) Previously, we identified a candidate gene, Tcp-10b, whose t allele generates alternatively spliced transcripts.
(6) Analysis of this mutant illustrates that indirect flight muscles and jump muscles utilize different mechanisms for alternative RNA splicing.
(7) A comparison between the primary structures of the rat and human genes reveals that the heterogeneity of the C-terminal peptides can be explained in large part by a frameshift mutation and the utilization of an alternative splice donor site in the third exon of the rat gene.
(8) A new alternative splice site was incidently found 81 nucleotide downstream of motif II in both normal and truncated 4.1 mRNA.
(9) The IGA-65 present in splicing extracts was distinguishable from known U-snRNP and hnRNP proteins on protein gels.
(10) The protein variation potentially includes N-terminal differences coded for by transcript-specific 5' exons and internal differences arising from the optional inclusion of a 39 base-pair exon and from the alternative use of two 3' splice sites separated by six base-pairs.
(11) Certain RNA molecules can mediate their own cleavage or splicing or act as enzymes to promote reactions on substrate RNA molecules.
(12) In order to identify putative protein splicing factors associated with the 200S InRNP particles, a panel of monoclonal antibodies directed against these particles were screened for their ability to inhibit splicing of pre-mRNA in vitro.
(13) Similar results were obtained when hybrid-selected RNA, which had been labeled for 3 h with [3H]uridine, was analyzed on formaldehyde-agarose gels, suggesting that the observed differences were due to splicing rather than RNA stability.
(14) At the restrictive temperature the ratio of unspliced U6 precursor to mature RNA is elevated in the mutants compared to the wild type grown under identical conditions, indicating a defect in U6 pre-RNA splicing.
(15) These two splicing intermediates cosedimented under a variety of conditions, indicating that they are contained in the same RNP complex.
(16) Recombinant retroviruses containing intact or spliced CRPV sequences can now be used to introduce the viral genes efficiently into a variety of cell lines.
(17) The 0.85 kb fragment was cloned and sequenced and the result indicated that the introns from the xylanase gene were accurately spliced by the plant cells.
(18) The RNA-catalysed self-splicing reaction of group II intron RNA is assumed to proceed by two consecutive transesterification steps, accompanied by lariat formation.
(19) U1 snRNA is an essential splicing factor known to base pair with 5' splice sites of premessenger RNAs.
(20) We have used such constructs, assayed by transient expression in chicken embryo fibroblasts, to define the minimal sequences necessary to inhibit splicing.