(superl.) Heaved or lifted with labor; not light; weighty; ponderous; as, a heavy stone; hence, sometimes, large in extent, quantity, or effects; as, a heavy fall of rain or snow; a heavy failure; heavy business transactions, etc.; often implying strength; as, a heavy barrier; also, difficult to move; as, a heavy draught.
(superl.) Not easy to bear; burdensome; oppressive; hard to endure or accomplish; hence, grievous, afflictive; as, heavy yokes, expenses, undertakings, trials, news, etc.
(superl.) Laden with that which is weighty; encumbered; burdened; bowed down, either with an actual burden, or with care, grief, pain, disappointment.
(superl.) Slow; sluggish; inactive; or lifeless, dull, inanimate, stupid; as, a heavy gait, looks, manners, style, and the like; a heavy writer or book.
(superl.) Strong; violent; forcible; as, a heavy sea, storm, cannonade, and the like.
(superl.) Loud; deep; -- said of sound; as, heavy thunder.
(superl.) Dark with clouds, or ready to rain; gloomy; -- said of the sky.
(superl.) Impeding motion; cloggy; clayey; -- said of earth; as, a heavy road, soil, and the like.
(superl.) Not raised or made light; as, heavy bread.
(superl.) Not agreeable to, or suitable for, the stomach; not easily digested; -- said of food.
(superl.) Having much body or strength; -- said of wines, or other liquors.
(superl.) With child; pregnant.
(adv.) Heavily; -- sometimes used in composition; as, heavy-laden.
(v. t.) To make heavy.
Example Sentences:
(1) We were instantly refused entrance by the heavies at the door.
(2) With the exception of PMMA and PTFE, all plastics leave a very heavy tar- and soot deposit after burning.
(3) One-nation prime ministers like Cameron found the libertarians useful for voting against taxation; inconvenient when they got too loud about heavy-handed government.
(4) The prevalence was also higher in medium and heavy smokers.
(5) These results indicate that the inhibition of CarAc by heavy metals occurs by binding of the sulfhydryl on the enzyme by the metals.
(6) The biggest single source of air pollution is coal-fired power stations and China, with its large population and heavy reliance on coal power, provides $2.3tn of the annual subsidies.
(7) The combined evidence from immunoglobulin light chain staining and the analysis of immunoglobulin heavy chain gene rearrangement indicated that the lesions in most patients represented polyclonal proliferations that gave rise to clonal subpopulations.
(8) Variations in light chain composition, particularly fast and slow myosin light chain 1, appeared to occur independently of the variations in heavy chain composition, suggesting that some myosin molecules consist of mixtures of slow- and fast-type subunits.
(9) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(10) But the condition of edifices such as B30 and B38 - and all the other "legacy" structures built at Sellafield decades ago - suggest Britain might end up paying a heavy price for this new commitment to nuclear energy.
(11) By applying this method to rat cardiac whole muscle, high-molecular weight proteins, such as myosin heavy chains, are focused on the first-dimensional gels and, in addition, minor components are resolved on the second-dimensional gels, without loss during equilibration with detergent.
(12) To identify cells of different myogenic lineages, myotubes were analyzed for content of fast and slow classes of myosin heavy chain (MHC) isoforms by immunocytochemistry and immunoblotting using specific monoclonal antibodies.
(13) Horses in heavy training may require more energy than they can consume on a conventional diet.
(14) As yet the observations demonstrate that workers exposed in their occupation to heavy metals (cadmium, lead, metalic mercury) and organic solvents should be subjected to special control for detection of renal changes.
(15) Heavy death losses (59%) occurred in adult Mystromys 3--14 days after muscle biopsies were taken from their rear legs.
(16) A comparative analysis of the structure and reactivity of the recombinant monoclonal antibodies showed that the light and heavy Ig-specific chains could form the reactive antibodies when the chains were present in different paratopes of Ig molecules.
(17) Mononucleosomes obtained from labeled cells were fractionated by rate zonal sedimentation through a sucrose gradient in heavy water (Senshu et al.
(18) Previous epitope mapping studies of human factor VIII (FVIII) inhibitor antibodies with heavy chain specificity localized epitopes to the amino-terminal half of the FVIII A2 domain.
(19) The ABI figures revealed that the best annuity for someone who is a heavy smoker and has severely impaired health was at Prudential, which paid out 46% more than the worst, from Friends Life.
(20) The parasites were highly aggregated within the study community, with most people harbouring low burdens while a few individuals harboured very heavy burdens.
Impenetrable
Definition:
(a.) Incapable of being penetrated or pierced; not admitting the passage of other bodies; not to be entered; impervious; as, an impenetrable shield.
(a.) Having the property of preventing any other substance from occupying the same space at the same time.
(a.) Inaccessible, as to knowledge, reason, sympathy, etc.; unimpressible; not to be moved by arguments or motives; as, an impenetrable mind, or heart.
Example Sentences:
(1) During the entire process the passage between the lumen and the intercellular space remained blocked by the tight junctions, as shown by their impenetrability to ferritin.
(2) Veering between a patronising video , a vague report and impenetrable financial data does not amount to openness and accountability.
(3) Similar results were obtained with subcutaneous or intraperitoneal thymus grafts and with thymus grafts within cell-impenetrable diffusion chambers.
(4) On the other hand, the performance of a material that is liquid-proof is absolute--it is impenetrable and can be accurately described as impervious.
(5) In a 70-page document that was largely ignored and almost completely impenetrable, he said the US intended to treat cyberspace as a military battleground.
(6) This last phenomenon appears to precede the entry of some axons into the neuropil and suggests that the glia limitans may not necessarily represent an impenetrable barrier to the passage of regenerating axons into the CNS.
(7) It appears that the major part of the exclusion volume is due to the collagen-fibril as a rod and the dextran coil as an impenetrable sphere.
(8) Some of the games are based around recognisable sports (like football), others around ancient samurai conflicts – but whatever the theme, the nature of the action is absolutely impenetrable to the casual onlooker.
(9) Many of the particles could therefore pass freely through tightly woven fabrics with pores up to 10-15 micrometer which might seem to be impenetrable to whole corneocytes, typically larger than 30 X 40 micrometer in the hydrated state.
(10) QSI's intentions are no doubt honest but if players as important as goalkeepers can be owned by anonymous third parties in impenetrable offshore companies the potential for match fixing is clear.
(11) The more complex a system, the more unintelligible and impenetrable is the map of possible side effects.
(12) Spontaneous postoperative expulsion of an IUD resulted in blockage or distortion of the anastomosis in 1 monkey; and in another the anastomosis was patent for a least 5 months, but later became impenetrable.
(13) Lactoperoxidase-catalyzed iodination (LCI) was carried out under impenetrable conditions in intact electroplax (where protein exposure on the external surface is monitored) and in split electroplax (where total protein labeling on both the external and internal monolayers of the plasma membrane bilayer is monitored).
(14) For 45 minutes, Arjen Robben twisted and turned with the ball only to find himself confronted by an impenetrable thicket of blue-shirted Brazil defenders.
(15) And viewed again in this mood, Libeskind's building, with its blank excoriated surfaces, looks closed to understanding; in material as in spirit, impenetrable.
(16) Subsequent chemical analysis of sperm-penetrable and impenetrable samples indicated that the concentrations of mucus nondialyzable solids (NDS), mucins, and soluble proteins were significantly higher in impenetrable specimens.
(17) The mites ate the germ before the endosperm, leaving an impenetrable layer of crushed endosperm cells between these regions.
(18) Two decades after Tutu made it a shining city of defiance amid seemingly impenetrable darkness, Cape Town is finding economic liberation harder than the political kind.
(19) Insensitivities at 190 and 100 nm were common to all five types of spores, indicating that these wavelengths were particularly impenetrant and absorbed by the outer layer materials.
(20) By announcing a huge programme of bond purchases , much bigger relative to the eurozone bond market than the quantitative easing implemented in the United States, Britain, or Japan, the ECB president, Mario Draghi, erected the impenetrable firewall that had long been needed to protect the monetary Union from a Lehman-style financial meltdown.