(superl.) Heaved or lifted with labor; not light; weighty; ponderous; as, a heavy stone; hence, sometimes, large in extent, quantity, or effects; as, a heavy fall of rain or snow; a heavy failure; heavy business transactions, etc.; often implying strength; as, a heavy barrier; also, difficult to move; as, a heavy draught.
(superl.) Not easy to bear; burdensome; oppressive; hard to endure or accomplish; hence, grievous, afflictive; as, heavy yokes, expenses, undertakings, trials, news, etc.
(superl.) Laden with that which is weighty; encumbered; burdened; bowed down, either with an actual burden, or with care, grief, pain, disappointment.
(superl.) Slow; sluggish; inactive; or lifeless, dull, inanimate, stupid; as, a heavy gait, looks, manners, style, and the like; a heavy writer or book.
(superl.) Strong; violent; forcible; as, a heavy sea, storm, cannonade, and the like.
(superl.) Loud; deep; -- said of sound; as, heavy thunder.
(superl.) Dark with clouds, or ready to rain; gloomy; -- said of the sky.
(superl.) Impeding motion; cloggy; clayey; -- said of earth; as, a heavy road, soil, and the like.
(superl.) Not raised or made light; as, heavy bread.
(superl.) Not agreeable to, or suitable for, the stomach; not easily digested; -- said of food.
(superl.) Having much body or strength; -- said of wines, or other liquors.
(superl.) With child; pregnant.
(adv.) Heavily; -- sometimes used in composition; as, heavy-laden.
(v. t.) To make heavy.
Example Sentences:
(1) We were instantly refused entrance by the heavies at the door.
(2) With the exception of PMMA and PTFE, all plastics leave a very heavy tar- and soot deposit after burning.
(3) One-nation prime ministers like Cameron found the libertarians useful for voting against taxation; inconvenient when they got too loud about heavy-handed government.
(4) The prevalence was also higher in medium and heavy smokers.
(5) These results indicate that the inhibition of CarAc by heavy metals occurs by binding of the sulfhydryl on the enzyme by the metals.
(6) The biggest single source of air pollution is coal-fired power stations and China, with its large population and heavy reliance on coal power, provides $2.3tn of the annual subsidies.
(7) The combined evidence from immunoglobulin light chain staining and the analysis of immunoglobulin heavy chain gene rearrangement indicated that the lesions in most patients represented polyclonal proliferations that gave rise to clonal subpopulations.
(8) Variations in light chain composition, particularly fast and slow myosin light chain 1, appeared to occur independently of the variations in heavy chain composition, suggesting that some myosin molecules consist of mixtures of slow- and fast-type subunits.
(9) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(10) But the condition of edifices such as B30 and B38 - and all the other "legacy" structures built at Sellafield decades ago - suggest Britain might end up paying a heavy price for this new commitment to nuclear energy.
(11) By applying this method to rat cardiac whole muscle, high-molecular weight proteins, such as myosin heavy chains, are focused on the first-dimensional gels and, in addition, minor components are resolved on the second-dimensional gels, without loss during equilibration with detergent.
(12) To identify cells of different myogenic lineages, myotubes were analyzed for content of fast and slow classes of myosin heavy chain (MHC) isoforms by immunocytochemistry and immunoblotting using specific monoclonal antibodies.
(13) Horses in heavy training may require more energy than they can consume on a conventional diet.
(14) As yet the observations demonstrate that workers exposed in their occupation to heavy metals (cadmium, lead, metalic mercury) and organic solvents should be subjected to special control for detection of renal changes.
(15) Heavy death losses (59%) occurred in adult Mystromys 3--14 days after muscle biopsies were taken from their rear legs.
(16) A comparative analysis of the structure and reactivity of the recombinant monoclonal antibodies showed that the light and heavy Ig-specific chains could form the reactive antibodies when the chains were present in different paratopes of Ig molecules.
(17) Mononucleosomes obtained from labeled cells were fractionated by rate zonal sedimentation through a sucrose gradient in heavy water (Senshu et al.
(18) Previous epitope mapping studies of human factor VIII (FVIII) inhibitor antibodies with heavy chain specificity localized epitopes to the amino-terminal half of the FVIII A2 domain.
(19) The ABI figures revealed that the best annuity for someone who is a heavy smoker and has severely impaired health was at Prudential, which paid out 46% more than the worst, from Friends Life.
(20) The parasites were highly aggregated within the study community, with most people harbouring low burdens while a few individuals harboured very heavy burdens.
Laden
Definition:
(p. & a.) Loaded; freighted; burdened; as, a laden vessel; a laden heart.
Example Sentences:
(1) We conclude that: 1) the effective capillary PO2 in the fetal brain can be significantly reduced by increasing the distance between non-methemoglobin-laden erythrocytes in capillaries and 2) hypoxic inhibition of fetal breathing probably arises from discrete areas of the brain having a PO2 less than 3 Torr.
(2) Histologically, 3-week explants showed only small areas of neointima with myofibroblasts and endothelial cells; the outer capsules were infiltrated by lipid-laden macrophages.
(3) The day it opened in the US, three senators – senate select committee on intelligence chairwoman Dianne Feinstein, Carl Levin and John McCain – released a letter of protest to Sony Pictures's CEO, citing their committee's 6,000-page classified report on interrogation tactics and calling on him "to state that the role of torture in the hunt for Osama bin Laden is not based on the facts, but rather part of the film's fictional narrative".
(4) The doom-laden voiceover claims Miliband could only secure power through a deal with the SNP and that Salmond would be able to “call the tune”.
(5) Contraction of the cell-laden gel occurred subsequently to create a new zone in the cell chamber.
(6) The debris-laden macrophages appear to migrate from the tail to the body.
(7) All organs took up 67Cu from both sources, but there was a tendency for increased uptakes in copper-deficient rats and decreased uptake in copper-laden rats.
(8) By light microscopy they contained lipid-laden cells (oil red O and Sudan black B positive), collagen, and much acid mucopolysaccharide.
(9) Yemen has long been the base of al-Qaida in the Arabian Peninsula, an offshoot of Osama bin Laden’s original group that has previously targeted Houthis.
(10) There is a perfectly illogical explanation for it; polio drops are meant to make us impotent and these programmes are run by the same people who managed to locate Osama bin Laden by running another scam vaccination campaign.
(11) I personally want to know how they caught bin Laden.
(12) The association of neutral fat-laden cells with the increase in lecithin could be due to a common origin from the skin of the fetus.
(13) Bin Laden himself headed north into the remote Afghan province of Kunar after the battle of Tora Bora in December 2001.
(14) Sure enough, the rowdy crowd in the Fox News audience gave him a lusty boo - the loudest of a rambunctious night and maybe of the entire primary season so far - while Gingrich called him "utterly irrational" for questioning the manner of Bin Laden's killing.
(15) In the letter, Gadahn – who the White House has announced was killed in a US drone stike in January – told the al-Qaida leader that Benjamin Franklin had never been a president of the United States and warned that if he or Ayman al-Zawahiri, Bin Laden’s deputy, made the mistake in propaganda speeches, their credibility would suffer.
(16) At least two of Bin Laden's sons – Hamza and Saad – apparently followed him into radicalism.
(17) In an attempt to reveal the role of antigen-laden marginal metallophil (MM) and other macrophages in the intrasplenic immune response of a specific B-cell lineage to a thymus-independent type-2 antigen (Ficoll conjugated with fluorescein isothiocyanate), simultaneous immunohistological observations of the involved cells were performed in the rat.
(18) The Associated Press quoted a US security source as saying the Somali raid was carried out by members of the same navy Seal team that killed the al-Qaida founder Osama bin Laden.
(19) Nurses' responses were more personalized and affect-laden.
(20) Bin Laden, who was 54 when he died, also had a copy of The America I Have Seen, a vitriolic memoir of a short trip to the US by the Egyptian thinker and activist Syed Qutb , considered the godfather of modern jihadi thinking and hanged in 1966.