(superl.) Heaved or lifted with labor; not light; weighty; ponderous; as, a heavy stone; hence, sometimes, large in extent, quantity, or effects; as, a heavy fall of rain or snow; a heavy failure; heavy business transactions, etc.; often implying strength; as, a heavy barrier; also, difficult to move; as, a heavy draught.
(superl.) Not easy to bear; burdensome; oppressive; hard to endure or accomplish; hence, grievous, afflictive; as, heavy yokes, expenses, undertakings, trials, news, etc.
(superl.) Laden with that which is weighty; encumbered; burdened; bowed down, either with an actual burden, or with care, grief, pain, disappointment.
(superl.) Slow; sluggish; inactive; or lifeless, dull, inanimate, stupid; as, a heavy gait, looks, manners, style, and the like; a heavy writer or book.
(superl.) Strong; violent; forcible; as, a heavy sea, storm, cannonade, and the like.
(superl.) Loud; deep; -- said of sound; as, heavy thunder.
(superl.) Dark with clouds, or ready to rain; gloomy; -- said of the sky.
(superl.) Impeding motion; cloggy; clayey; -- said of earth; as, a heavy road, soil, and the like.
(superl.) Not raised or made light; as, heavy bread.
(superl.) Not agreeable to, or suitable for, the stomach; not easily digested; -- said of food.
(superl.) Having much body or strength; -- said of wines, or other liquors.
(superl.) With child; pregnant.
(adv.) Heavily; -- sometimes used in composition; as, heavy-laden.
(v. t.) To make heavy.
Example Sentences:
(1) We were instantly refused entrance by the heavies at the door.
(2) With the exception of PMMA and PTFE, all plastics leave a very heavy tar- and soot deposit after burning.
(3) One-nation prime ministers like Cameron found the libertarians useful for voting against taxation; inconvenient when they got too loud about heavy-handed government.
(4) The prevalence was also higher in medium and heavy smokers.
(5) These results indicate that the inhibition of CarAc by heavy metals occurs by binding of the sulfhydryl on the enzyme by the metals.
(6) The biggest single source of air pollution is coal-fired power stations and China, with its large population and heavy reliance on coal power, provides $2.3tn of the annual subsidies.
(7) The combined evidence from immunoglobulin light chain staining and the analysis of immunoglobulin heavy chain gene rearrangement indicated that the lesions in most patients represented polyclonal proliferations that gave rise to clonal subpopulations.
(8) Variations in light chain composition, particularly fast and slow myosin light chain 1, appeared to occur independently of the variations in heavy chain composition, suggesting that some myosin molecules consist of mixtures of slow- and fast-type subunits.
(9) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(10) But the condition of edifices such as B30 and B38 - and all the other "legacy" structures built at Sellafield decades ago - suggest Britain might end up paying a heavy price for this new commitment to nuclear energy.
(11) By applying this method to rat cardiac whole muscle, high-molecular weight proteins, such as myosin heavy chains, are focused on the first-dimensional gels and, in addition, minor components are resolved on the second-dimensional gels, without loss during equilibration with detergent.
(12) To identify cells of different myogenic lineages, myotubes were analyzed for content of fast and slow classes of myosin heavy chain (MHC) isoforms by immunocytochemistry and immunoblotting using specific monoclonal antibodies.
(13) Horses in heavy training may require more energy than they can consume on a conventional diet.
(14) As yet the observations demonstrate that workers exposed in their occupation to heavy metals (cadmium, lead, metalic mercury) and organic solvents should be subjected to special control for detection of renal changes.
(15) Heavy death losses (59%) occurred in adult Mystromys 3--14 days after muscle biopsies were taken from their rear legs.
(16) A comparative analysis of the structure and reactivity of the recombinant monoclonal antibodies showed that the light and heavy Ig-specific chains could form the reactive antibodies when the chains were present in different paratopes of Ig molecules.
(17) Mononucleosomes obtained from labeled cells were fractionated by rate zonal sedimentation through a sucrose gradient in heavy water (Senshu et al.
(18) Previous epitope mapping studies of human factor VIII (FVIII) inhibitor antibodies with heavy chain specificity localized epitopes to the amino-terminal half of the FVIII A2 domain.
(19) The ABI figures revealed that the best annuity for someone who is a heavy smoker and has severely impaired health was at Prudential, which paid out 46% more than the worst, from Friends Life.
(20) The parasites were highly aggregated within the study community, with most people harbouring low burdens while a few individuals harboured very heavy burdens.
Leaden
Definition:
(a.) Made of lead; of the nature of lead; as, a leaden ball.
(a.) Like lead in color, etc. ; as, a leaden sky.
(a.) Heavy; dull; sluggish.
Example Sentences:
(1) There is a heavy, leaden feeling in your chest, rather as when someone you love dearly has died; but no one has – except, perhaps, you.
(2) In ancient Rome and during the Renaissance compression by means of leaden plates was a well-known treatment of cancer.
(3) DCMS secretary Maria Miller last week promised to fight for the arts: untouched by loftier values her leaden utilitarianism in calling the arts a "compelling product" came under fire, but she did lay out a good commercial case.
(4) There is no way that the show could have been made without it, because otherwise all the action would have been leaden with exposition.
(5) The murine dilute suppressor gene, dsu, was previously shown to suppress the dilute coat color phenotypes of mice homozygous for the dilute (d), leaden (ln), and ashen (ash) mutations.
(6) Sixty patients with probable atypical depression--defined as meeting Research Diagnostic Criteria for depressive illness, having reactive mood, and having one of four associated symptoms (hyperphagia, hypersomnolence, leaden feeling, and sensitivity to rejection)--took part in a study contrasting phenelzine, imipramine, and placebo.
(7) The football was leaden in the first half and, once again, there were times when an impatient crowd struggled to contain their frustrations.
(8) The syndrome is characterized by profound dysfunction of the central nervous system, silver-leaden colored hair, abnormal melanosomes and melanocytes, and abnormal inclusion bodies in fibroblasts, bone marrow histiocytes and lymphocytes which appear to represent abnormal lysosomal bodies.
(9) In addition, scatter radiation exposure of the head decreased by 54% by covering the patient with a rubber leaden blanket (0.25 mm Pb).
(10) They left as the leaden sun started to dip; federal police stretched yellow crime scene tape around the sites.
(11) 6.08pm BST 36 min: A leaden-footed touch from Weimann puts the ball out of play deep in Liverpool territory, surrendering possession to the visitors in the form of a throw-in.
(12) The hour struck, 9.17pm, and leaden silence fell, broken only by the babble of TV reporters beside their mobile trucks.
(13) In the fifteenth his legs were leaden; Frazier punished him immediately and before the round had gone a minute a sickeningly violent left hook smashed across the right side of Ali's face, instantly increasing the swelling that had developed there earlier and lifting him flat on his back with his legs kicking high towards the ring lights.
(14) If it’s just going to be leaden, and heavy, and bureaucratic, we will lose out.” Speaking to the Guardian as the CBI launches a new report analysing the factors that make some regions more economically successful than others, Fairbairn urged the government to invest more in boosting school standards in order to help address the financial concerns that led to Brexit.
(15) 9.13pm BST 12 min: A leaden touch from Jerome Boateng on the edge of his own penalty area puts Per Mertesacker under pressure from Slimani, but the German centre-half clears.
(16) As sendoffs go, it is probably fair to say Roy Hodgson hoped for better in England’s final match before Euro 2016 than seeing his team look so leaden, the crowd so bored they resorted to making their own entertainment and a tetchy press conference when the questions centred around whether his team were heading into another tournament without any clarity about their best way of playing.
(17) Dowsett set off at positively leaden pace in the opening lap and a half but once he hit cruising speed, he maintained the same even pace throughout, covering most of his laps in about 17sec, raising his game approaching the half-hour and pushing hard in the final 15 minutes.
(18) 14 min: A decent scoring opportunity for Brazil goes to waste after a disappointingly leaden-footed touch from Neymar, who is sporting an interesting mohawk type barnet that makes him resemble a toilet brush.
(19) Through the leaden rain of a battleship-grey morning in one of the poorest neighbourhoods in Britain drifts a flurry of music by Antonio Vivaldi.
(20) An enhanced development of pituitary tumors was observed in virgin female mice of the C57 Leaden strain following repeated oral administration of synthetic progestins.