(superl.) Heaved or lifted with labor; not light; weighty; ponderous; as, a heavy stone; hence, sometimes, large in extent, quantity, or effects; as, a heavy fall of rain or snow; a heavy failure; heavy business transactions, etc.; often implying strength; as, a heavy barrier; also, difficult to move; as, a heavy draught.
(superl.) Not easy to bear; burdensome; oppressive; hard to endure or accomplish; hence, grievous, afflictive; as, heavy yokes, expenses, undertakings, trials, news, etc.
(superl.) Laden with that which is weighty; encumbered; burdened; bowed down, either with an actual burden, or with care, grief, pain, disappointment.
(superl.) Slow; sluggish; inactive; or lifeless, dull, inanimate, stupid; as, a heavy gait, looks, manners, style, and the like; a heavy writer or book.
(superl.) Strong; violent; forcible; as, a heavy sea, storm, cannonade, and the like.
(superl.) Loud; deep; -- said of sound; as, heavy thunder.
(superl.) Dark with clouds, or ready to rain; gloomy; -- said of the sky.
(superl.) Impeding motion; cloggy; clayey; -- said of earth; as, a heavy road, soil, and the like.
(superl.) Not raised or made light; as, heavy bread.
(superl.) Not agreeable to, or suitable for, the stomach; not easily digested; -- said of food.
(superl.) Having much body or strength; -- said of wines, or other liquors.
(superl.) With child; pregnant.
(adv.) Heavily; -- sometimes used in composition; as, heavy-laden.
(v. t.) To make heavy.
Example Sentences:
(1) We were instantly refused entrance by the heavies at the door.
(2) With the exception of PMMA and PTFE, all plastics leave a very heavy tar- and soot deposit after burning.
(3) One-nation prime ministers like Cameron found the libertarians useful for voting against taxation; inconvenient when they got too loud about heavy-handed government.
(4) The prevalence was also higher in medium and heavy smokers.
(5) These results indicate that the inhibition of CarAc by heavy metals occurs by binding of the sulfhydryl on the enzyme by the metals.
(6) The biggest single source of air pollution is coal-fired power stations and China, with its large population and heavy reliance on coal power, provides $2.3tn of the annual subsidies.
(7) The combined evidence from immunoglobulin light chain staining and the analysis of immunoglobulin heavy chain gene rearrangement indicated that the lesions in most patients represented polyclonal proliferations that gave rise to clonal subpopulations.
(8) Variations in light chain composition, particularly fast and slow myosin light chain 1, appeared to occur independently of the variations in heavy chain composition, suggesting that some myosin molecules consist of mixtures of slow- and fast-type subunits.
(9) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(10) But the condition of edifices such as B30 and B38 - and all the other "legacy" structures built at Sellafield decades ago - suggest Britain might end up paying a heavy price for this new commitment to nuclear energy.
(11) By applying this method to rat cardiac whole muscle, high-molecular weight proteins, such as myosin heavy chains, are focused on the first-dimensional gels and, in addition, minor components are resolved on the second-dimensional gels, without loss during equilibration with detergent.
(12) To identify cells of different myogenic lineages, myotubes were analyzed for content of fast and slow classes of myosin heavy chain (MHC) isoforms by immunocytochemistry and immunoblotting using specific monoclonal antibodies.
(13) Horses in heavy training may require more energy than they can consume on a conventional diet.
(14) As yet the observations demonstrate that workers exposed in their occupation to heavy metals (cadmium, lead, metalic mercury) and organic solvents should be subjected to special control for detection of renal changes.
(15) Heavy death losses (59%) occurred in adult Mystromys 3--14 days after muscle biopsies were taken from their rear legs.
(16) A comparative analysis of the structure and reactivity of the recombinant monoclonal antibodies showed that the light and heavy Ig-specific chains could form the reactive antibodies when the chains were present in different paratopes of Ig molecules.
(17) Mononucleosomes obtained from labeled cells were fractionated by rate zonal sedimentation through a sucrose gradient in heavy water (Senshu et al.
(18) Previous epitope mapping studies of human factor VIII (FVIII) inhibitor antibodies with heavy chain specificity localized epitopes to the amino-terminal half of the FVIII A2 domain.
(19) The ABI figures revealed that the best annuity for someone who is a heavy smoker and has severely impaired health was at Prudential, which paid out 46% more than the worst, from Friends Life.
(20) The parasites were highly aggregated within the study community, with most people harbouring low burdens while a few individuals harboured very heavy burdens.
Overwhelming
Definition:
(p. pr. & vb. n.) of Overwhelm
(a.) Overpowering; irresistible.
Example Sentences:
(1) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(2) She added: “We will continue to act upon the overwhelming majority view of our shareholders.” The vote was the second year running Ryanair had suffered a rebellion on pay.
(3) T cells admixed in the germinal centers were overwhelmingly of the T-helper type.
(4) Unfortunately for the governor, he could win both states and still face the overwhelming likelihood of failure if he doesn't take Ohio, where the poll found Obama out front 51-43.
(5) In Britain, the European election is overwhelmingly seen through the prism of domestic politics.
(6) Photograph: Christopher Thomond for the Guardian Asked if Watson should seek to refresh his mandate after Corbyn’s overwhelming victory among members, McCluskey added: “Well, if Tom wants to try to refresh his mandate it would be interesting to see what happens.” Watson said it was time “to be proud of our party”, because the Conservatives were beatable and the prime minister, Theresa May, could call an election any time.
(7) The government acknowledged it had been overwhelmed by the devastation from the deadliest quake in Nepal in over 80 years.
(8) He made me laugh and cry, and his courage in writing about what he was going through was sometimes quite overwhelming.
(9) Although alpha 1-antiprotease (alpha 1-AP) binds and inactivates NE and is the major antielastase of the lower respiratory tract, antielastase defenses may be overwhelmed in CF, leading to progressive lung damage.
(10) And HAP has shown that the key finding that debt slows growth was driven overwhelmingly by the exclusion of four years of data from New Zealand.
(11) Cathepsin D-like acid proteinase existed overwhelmingly in the mucosal layer and was hardly detected in the gastric juice.
(12) Hence, reaction of chemical carcinogen with nuclear DNA is possible only when the cell is overwhelmed leading to cell death, or following a temporary breach of the nuclear membrane control points, but the DNA damage in the latter is totally reparable.
(13) The facts are clear: the overwhelming majority of EU citizens in Britain are contributors, not freeloaders.” But that was not the official position of any of the parties involved, so it went mostly unsaid.
(14) Of 54 patients with poor-grade aneurysms, ventriculostomy was placed in 47 (87.0%) and yielded high ICP's in the overwhelming majority, with the mean ICP being 40.2 cm H2O.
(15) There is overwhelming evidence, today, that such factors are involved in the manifestation of acute as well as chronic, non-specific as well as well as specific inflammation.
(16) Mobile phone networks, overwhelmed by demand, were down for hours, with authorities advising people to use email or text messages instead.
(17) The immunity was enacted by an overwhelming bipartisan vote, with the support of leading Democrats including Barack Obama, who had promised - when seeking his party's nomination - to filibuster any bill that contained retroactive telecom immunity.
(18) There’s an overwhelming sadness among kids like that who have been kept there for a very long time.
(19) Panic attacks would overwhelm her periodically and she experienced regular “ scanxiety ” – the feelings of dread that grip patients before new tests.
(20) In the meantime, Malaysia Airlines’ overwhelming focus will be the same as it has been from the outset – to provide the families with a comprehensive support programme.