(adv.) Up to this time; hitherto; before; in time past.
Example Sentences:
(1) The heretofore "permanently and totally disabled versus able-bodied" principle in welfare reforms is being abbandoned.
(2) All cases heretofore described in immunocompromised hosts have involved the external auditory canal and mastoid areas.
(3) Heretofore, human tumor clonogenic assays or human glioma-bearing nude mice models were usually used for predicting the drug sensitivity of brain tumor.
(4) It is concluded that the heretofore pessimistic outlook regarding complete quadriplegia is unwarranted and that a more aggressive approach may result in a better functional outcome.
(5) Since basilar artery thrombosis is now a treatable condition, early diagnosis and documentation of functional deficits moves into a more important clinical area than heretofore.
(6) Taken together, these results suggest that processing of alpha-MSH is unlike that heretofore described for other peptide antigens and seems to involve APC handling to form the stimulatory moiety presented on the APC surface.
(7) However, the electrofocusing pattern of renin from pituitary tissue (pI = 4.43, 5.77) differed from that of plasma and kidney enzymes heretofore reported, a discrepancy which could be interpreted as evidence for the endogeneous synthesis of renin in the brain tissue.
(8) The facts that (a) essentially all particles, regardless of orientation, entrap cells, and (b) nonporous particles also entrap cells with high efficiency, indicate that filtration effects are irrelevant and that heretofore unrecognized hydrodynamic forces are alone responsible for the cell immobilization.
(9) Perhaps alpha activation is indicative of stimulating and excitatory effects induced by m-xylene exposure, which has been noted heretofore in the absorption phase of alcohol intake.
(10) The important otolaryngological manifestations of arthrogryposis multiplex congenita (AMC), which heretofore have not been described in otolaryngological and other specialty journals, are reviewed.
(11) Finding the chromosomal location of human genes that heretofore have been defined solely by phenotypes, in particular clinical phenotypes that are transmitted in Mendelian fashion in families, is an early and often crucial step in the process of identifying the molecular basis of a disease.
(12) Tumors of the skull base with carotid artery involvement have heretofore required carotid ligation or been deemed inoperable.
(13) Heteroplasmy, heretofore rarely observed, occurred frequently in these same two regions.
(14) Heretofore, unresolved was the question which skin element causes stimulation of vessel formation in this lesion: the epidermis, the dermis, vessels themselves, inflammatory cells, and so forth.
(15) The induction of experimental allergic encephalomyelitis (EAE) with purified myelin basic protein (MBP) has, heretofore, required its incorporation in a water-in-oil emulsion or adsorption on particulate adjuvants.
(16) These anomalies in trisomy 22 mosaicism have not been emphasized heretofore.
(17) A detailed examination of a stillborn fetus with Apert's syndrome showed several unexpected findings, which prompted a reevaluation of the heretofore generally accepted hypotheses regarding the cause of the dysmorphic craniofacial features in this syndrome.
(18) Today's perspective of the endothelial cell recognizes its real significance, heretofore neglected, and anticipates important future contributions to improved medical management.
(19) Juan Salgado, community leader creating a model for workforce development and training among immigrant communities through a holistic approach that addresses language skills, education and other barriers to entering the workforce Beth Stevens, neuroscientist revealing the heretofore unknown role of microglial cells in neuron communication and prompting a fundamental shift in thinking about brain development in both healthy and unhealthy states.
(20) Multiple pyogenic granuloma-like lesions occurring at punch graft sites are an unusual complication of hair transplantation heretofore unreported.
Hitherto
Definition:
(adv.) To this place; to a prescribed limit.
(adv.) Up to this time; as yet; until now.
Example Sentences:
(1) Electron microscopy revealed the presence of a hitherto unreported peculiar "pilovacuolar" inclusion in numerous mitochondria, composed of an electron dense pile or rod within a vacuole, while globular or crystalline inclusions were absent.
(2) The anomaly may represent a hitherto overlooked but easily obtainable diagnostic marker.
(3) As regards other factors, however, whose causative role has hitherto been considered proven or at least very probable, no differences were found between patients and controls (e.g.
(4) This model was recently introduced into the stereology of myocardial capillaries and leads to a more accurate quantitation of the capillary network than parameters used hitherto, such as the "capillary density" (number of capillary profiles per mm2 of cross sectional area) and the "capillary-fiber ratio" (number of capillary profiles per number of myofiber profiles in cross sections).
(5) The carcinostatic effect of the hitherto unknown N-(2-cyanethylene) urea is descirbed.
(6) It is concluded that SLE is not as uncommon in black South Africans as was believed hitherto.
(7) Hitherto unsuspected biosynthetic heterogeneity is present in the glands.
(8) Hitherto performed abdominoperineal or sacroperineal procedures entailed major traumatizing surgery with an inherent risk of complications.
(9) In fact, the overall efficacy of CSFs has been outstanding for disorders hitherto viewed as otherwise refractory.
(10) It is suggested that the condition is more common than hitherto reported and is often confused with maturation arrest.
(11) One case of tubal endometrioid carcinoma has been reported previously, but the entity has not hitherto been recognized among primary fallopian tube tumors.
(12) Controlled behavioural testing confirmed the apparent agnosia but revealed that he could be trained to make a number of visual discriminations which had not been apparent from routine clinical examination and that he suffered a number of subtle sensory impairments which likewise had not hitherto been apparent.
(13) Hitherto there have been hardly any paediatric investigation into the effect of sport on children,--apart from physiological ones, (Rutenfranz).
(14) The present study has shown a hitherto unknown axo-axonic cell in the rat fascia dentata.
(15) The importance of the m. canalis ani and of the hitherto unknown transsphincteric course of the blood reflux from the arterially supplied corpus cavernosum for the pathogenesis of the hemorrhoidal disease as the adequate therapy are delineated.
(16) According to the results in hand there exists a contradiction to the opinions hitherto existing about a distinct age dependence in the bone structure and distinct sex differences in the findings of the structures of the Ist order.
(17) The progressive fusion of the neural folds during stage 10, and the closure of the rostral and caudal neuropores at stages 11 and 12, respectively, are detailed with further precision than hitherto.
(18) Hitherto, the duration of the perfusion has been extended to 10 h. After this time the endothelium was well preserved.
(19) The hitherto recommended treatment, pyrimethamine in combination with sulphonamides, is often associated with severe side-effects.
(20) These spontaneous fluctuations of the blood lithium level, a hitherto unreported phenomenon are discussed as a possible cause of the lithium intoxication.