(1) The first concerns precursor cells that give rise to lambda-bearing NP-specific antibodies with heteroclitic fine specificity.
(2) The data suggest that the humoral response to different epitopes of a protein antigen during the maturation of the immune response is a stochastic process leading to transient humoral immunodominance, enhancing Ab populations and heterocliticity, depending upon individual characteristics, either in outbred or inbred populations.
(3) The goal of these experiments has been to capitalize on the functionally distinct responses of heteroclitic CTL to cross-reactive Ag to explore the role of Ag in regulating CTL proliferation and lytic function.
(4) It is predicted that a combination of solid-phase competition assay with high epitope density and direct binding assay with low epitope density would result in optimal detection of heteroclitic antibodies and small differences in antibody affinity for cross-reactive antigens.
(5) By contrast, the heteroclitic Abs to eGH developed by hypopituitary patients therapeutically injected with human growth hormone failed to react with any eGH-derived fragment.
(6) m ABs 8 to 14 and 16 to 20 demonstrated heteroclitic behavior, that is, they bound CTT IIIa better than the immunogen CTT III.
(7) One assay method failed to detect heteroclitic activity of 1 antibody which was clearly evident in the other 3 assays.
(8) Moreover, some anti-BP mAbs and anti-Cop 1 mAbs reacted in a heteroclitic manner and favored the cross-reactive antigen over the immunogen.
(9) However, immunization with the heterologous peptide resulted in a response strictly directed to rat CII and the immunogen while immunization with the autologous peptide elicited T cells which reacted in a heteroclitic fashion, with a stronger response to the heterologous peptide than to the autologous peptide, and did respond to rat CII but not to mouse CII.
(10) Polypeptides (Lys-Ser-Glu)n induced cross-reacting or heteroclitic antibodies.
(11) Monoclonal and anti-dinitrophenyl and anti-trinitrophenyl IgE antibodies were used to measure heterocliticity using competitive inhibition assays with homologous and heterologous haptens.
(12) To our knowledge, this is the first description of a T cell clone that is specific for a class I antigen and cross-reacts heteroclitically with a class II antigen.
(13) A number of antibodies showed heteroclitic binding to particular insulin variants.
(14) Med., 146 (1977) 1323-1331), by comparing the encephalitogenic guinea pig sequence to a less potent analog, had also previously observed what now would be termed a heteroclitic phenomenon at the T cell level in Lewis rats.
(15) In this report, we employ a competition assay to confirm that this alloresponse involves a groove-binding peptide, demonstrate that this peptide derives from or depends on fetal calf serum and exploit a panel of antigen-presenting cell lines--each displaying an Ak complex with a different position 69 substitution--to establish that the alloresponse is not just a heteroclitic response to ribonuclease, itself.
(16) The results indicated temporal and individual variations in the titers of each class of Ab as well as the existence of enhancer and heteroclitic Ab.
(17) Products of both genes had an exotic (heteroclitic) fine-specificity.
(18) Although most of the animals showed cross-reacting Ab, two out of 12 mice, chronically injected, developed heteroclitic Ab.
(19) Heterocliticity towards non-human GH was also detected.
(20) Some of the antibodies could be inhibited to a greater degree with the cross-reacting haptens than with the haptens homologous to the immunizing antigen, therefore these antibodies were heteroclitic.
Uncountable
Definition:
Example Sentences:
(1) It is not known how many killings by police officers go uncounted in the United States each year.
(2) By restraining the lateral spread and confluence of colonies, the hydrophobic grid-membrane filter (HGMF) allows growth- or colony-forming units (GU) to be resolved at levels far above those which produce an uncountable lawn on a conventional membrane filter.
(3) In a canyon between grey shattered precipices of bomb-ravaged buildings, an uncountable number of people wait for food.
(4) The first-ever attempt by US record-keepers to estimate the number of uncounted “law enforcement homicides” exposed previous official tallies as capturing less than half of the real picture.
(5) But Kyte added: “If they all had access to coal-fired power tomorrow their respiratory illness rates would go up, etc, etc … We need to extend access to energy to the poor and we need to do it the cleanest way possible because the social costs of coal are uncounted and damaging, just as the global emissions count is damaging as well.” The World Bank sees climate change as a driver of poverty, threatening decades of development.
(6) There are uncountable things that only a human can do, and that no computer seems close to.
(7) Some degree of carpeting of the colonic mucosa and uncountable numbers fo tumors occurred in 30% of mice and these areas of confluent neoplasms also occurred predominantly in the distal colon.
(8) Simulations with this model show that: (1) none of the postural maintenance schemes considered in these simulations (including varying anticipation) could suppress the initial backward thrust on the body link; (2) the more important destabilizing perturbation is a subsequent forward sway that, left uncountered by postural activity, would eventually leave the body to fall flat on its face; and (3) anticipatory silencing of the postural extensor followed by a brief period of extensor activation (descending control) and synchronous reflex activity (feedback control) appears to be the most likely postural stabilizing strategy that inhibits the continuous forward sway and is consistent with the experimental evidence.
(9) Moscow remains wary of the Afghan quagmire, with memories still fresh of the disastrous 1979-89 war that cost the lives of 15,000 Russian soldiers and uncounted Afghan civilians, and ultimately contributed to the collapse of the Soviet Union.
(10) The uncounted: why the US can't keep track of people killed by police Read more Cummings told the Guardian he was convening the debate “because I believe we have a unique moment of bipartisan, nationwide support to reform our criminal justice system – a system that has led to the over-criminalization, imprisonment, and even deaths of Americans across the country, particularly in communities of color.
(11) An average of 545 people killed by local and state law enforcement officers in the US went uncounted in the country’s most authoritative crime statistics every year for almost a decade, according to a report released on Tuesday.
(12) The core business of the BBC is broadcasting – it's there in the name – and if it has to make a choice between radio, television and an uncountable number of web pages then radio and TV should always come first.
(13) The abdominal pathologies that can be studied are almost uncountable: gastric neoplasms, pancreatic cysts and stones, gallstones, neoplasms of the liver and pancreas, bowel tumors, abdominal aortic aneurysms, renal neoplasms and cysts, atrophy of the kidneys, bladder tumors, uterine tumors, ovarian cysts, and many more.
(14) Wyden warned that the uncounted FBI searches posed a particular problem, both substantively and for oversight.
(15) I hope that neither place continues to act as a graveyard; full of the uncounted remains of people we preferred not to think about or see as equal to ourselves.
(16) The amplitude reduction associated with a CVA cannot be simply interpreted as evidence for reduced cognitive efficiency because overall amplitudes and intercorrelations between brain regions of CVA patients were reduced for both counted and uncounted stimuli.
(17) But the majority of victims in law enforcement homicides for those years not only went unnamed – they went uncounted in any one tally.
(18) Simulations also predict that any postural activities in the hips and lower limbs should be a two-fold process: first, some preprogrammed, descending control to the lower body would be required to actively enhance the passive, backwards motion (this is consistent with, though not strictly identical to, the hypothesis of Crenna and colleagues); secondly, there must be a subsequent activation in the anterior muscles of the lower body in order to arrest this backwards motion, since otherwise the uncountered momentum would carry the body backward to the floor in less than half a second after the upper body movement has terminated.
(19) Operation Ellamy cost the British taxpayer hundreds of millions of pounds; what it cost the Libyan people is uncountable.
(20) A justice department investigation of the FBI’s published statistics has already revealed the worst from a data standpoint: more than half the people killed by local and state law enforcement officers in the US went uncounted in the country’s most authoritative crime statistics every year, for almost a decade.