(n.) An abnormal formation foreign to the economy, and composed of elements different from those are found in it in its normal condition.
Example Sentences:
(1) The common occurrence in the marine mussel Mytilus of heteroplasmic individuals with two or more types of highly diverged mtDNA molecules was interpreted as strong evidence for biparental mtDNA inheritance by some, but not by others.
(2) Approximately half of these transformants were initially heteroplasmic for copies of the disrupted atpB or rbcL genes integrated into the recipient chloroplast genome but still retained photosynthetic competence.
(3) In two localities, we found individuals with heteroplasmic mtDNA which had different numbers of the 160-bp repeats mentioned above.
(4) Several lines were heteroplasmic for the length of the genome.
(5) The heteroplasmic NCS6 striped plants carry both partially deleted and normal versions of the mitochondrial cytochrome oxidase subunit 2 (cox2) gene and have low levels of cox2 transcripts when compared with nonstriped control plants.
(6) We studied 23 patients with clinically defined mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), 25 oligosymptomatic or asymptomatic maternal relatives, and 50 mitochondrial disease control subjects for the presence of a previously reported heteroplasmic point mutation at nt 3,243 in the transfer RNA(Leu(UUR)) gene of mitochondrial DNA.
(7) A patient heteroplasmic for the bp 8344 mutation (associated with myoclonic epilepsy and ragged red fibres: MERRF) showed subnormal COX activity within RRF, although the tissue distribution of mtDNA and its transcripts was similar to that seen with the bp 3243 mutation.
(8) A heteroplasmic A to G transition mutation in the mitochondrial encoded tRNA(Lys) gene at nucleotide pair 8344 has been suggested to be linked to the MERRF-syndrome.
(9) Single cell cloning of the initially heteroplasmic transformants also yielded nonphotosynthetic segregants that were homoplasmic for the disrupted gene.
(10) The functional consequences of large heteroplasmic mtDNA deletions were investigated in a group of 6 patients with chronic progressive external ophthalmoplegia (CPEO) syndromes.
(11) In CPEO, 31 of 40 patients had deleted mtDNA in a heteroplasmic distribution; the mutant mtDNA were present in a large amount in the skeletal muscle and other symptomatically affected organs as observed on Southern blotting and polymerase chain reaction (PCR).
(12) Disorders resulting from heteroplasmic mutations of mitochondrial genes may appear to be sporadic rather than familial.
(13) In three of these the maternal type was completely replaced while the fourth was heteroplasmic.
(14) Translation of all mtDNA-encoded genes was severely depressed in homoplasmic mutant myoblast clones but not in heteroplasmic or wild-type clones.
(15) The parental mtDNAs were quantitated in heteroplasmic cells by using restriction fragment length polymorphisms (RFLPs) detected in Southern blots.
(16) heteroplasmic) population of normal and deleted mitochondrial DNAs, or only normal mitochondrial DNAs (i.e.
(17) The frequencies of mtDNA size variants in heteroplasmic females and samples of their offspring were estimated by densitometry of autoradiographs.
(18) large-scale heteroplasmic deletions in syndromes with progressive external ophthalmoplegia and point mutations in MELAS and MERRF encephalomyopathies.
(19) Southern blot analysis revealed a 4.7 kb heteroplasmic deletion of the mitochondrial DNA mapping within genes coding for subunits of complexes I, IV and V of the respiratory chain and for tRNA.
(20) In this study, we correlated heteroplasmic mtDNA abnormality with clinical, biochemical and histological findings with the following results: (1) large deletions ranging from 1.8 to 8.8 kb in 22 muscle specimens from 28 patients who had ophthalmoplegia clinically and focal cytochrome c oxidase (CCO) deficiency by histochemistry, (2) no difference in clinical and biochemical findings between patients with and without mtDNA deletions, (3) no relationship between the size, site or populations of deleted mtDNA and respiratory chain enzyme activities in muscles, (4) positive correlation between the number of CCO-deficient fibers and the populations of deleted mtDNA, and (5) higher incidence of CCO-negative fibers in patients with deleted mtDNA than in those with no deletion of mtDNA.
Heteroplastic
Definition:
(a.) Producing a different type of organism; developing into a different form of tissue, as cartilage which develops into bone.
Example Sentences:
(1) Reference is made to the possible use of cardiac valves of animal origin as heteroplastic material in cardiac valve surgery.
(2) Recipients of a heteroplastic eye recovered the reaction as frequently and to the same extent as animals with one of their own eyes reattached.
(3) In addition, teratoid medulloepithelioma, a tumor arising from the ciliary epithelium, can contain a rhabdomyoblastic component, often in combination with other heteroplastic elements.
(4) Heteroplastic bone was evaluated according to Brooker's criteria, in the investigated group only type I was found.
(5) Trypsin was used to isolate adult mouse (heteroplastic) or rat (homoplastic) pancreatic ductal epithelium and fetal rat mesenchyme.
(6) The World Health Organisation histological classification of medulloepithelioma was applied, but some problems were encountered, particularly where the presence of heteroplastic brain tissue was used as a criterion for teratoid tumour and where rosettes were used as a criterion for malignancy.
(7) Teratoid medulloepitheliomas, which we considered the most advanced and malignant lesions, consisted of heterogeneous, highly mitotic, invasive cells and contained heteroplastic elements including striated muscle, undifferentiated mesenchymal tissues, and hyaline cartilage.
(8) Their prevalence is analogous of the general population for those diseases easily detectable by US, such as cystic and heteroplastic diseases.
(9) The intention is also to demonstrate how at times symptomatology and clinical objectivity are not always enough to guide the physician to correct diagnosis; where historical data are lacking, clinical objectivity, often suggest neoformation of heteroplastic type or aspecific chronic inflammation rather than granulomatous reactions due to foreign bodies.
(10) Changes of tissue pO2 levels in chronic subcutis wounds with and without heteroplastic tumour spheroid implants in thoraco-lumbal rat skinfolds covered by transparent chambers were followed in crosscut analysis by pO2 surface electrodes as a function of post-operative age using constant normoxic, hypoxic, post-hypoxic breathing conditions and intervals for each measured area.
(11) A heteroplastic eye transplant can reinstate the latter reaction.
(12) Phenoloxidase containing cells (POZ) identified with histochemical techniques in the subcutaneous connective tissue showed a marked increase in their number in response to heteroplastic skin transplantation in the rat.
(13) The common knowledge according to which all heteroplastic structures need a large quantity of O2 and provoke the formation of new vessels with the angiogenesis factor, with particularly rapid, and tumultuous fluxes due to the presence of shunt, is the basis for the use of color doppler in research on neoplasia in the initial phase.
(14) In femoro-popliteal reconstructions proximal to the knee joint alloplastic and heteroplastic material are being used increasingly instead of the autologous vein, even though the latter is still unmatched for quality.
(15) Heteroplastic elements (brain tissue, cartilage, or rhabdomyoblasts) were observed in four benign and 17 malignant tumors; these 21 were designated teratoid medulloepitheliomas.
(16) In only two cases (since 1963) was it necessary to resort to heteroplastic material, viz.
(17) This work assesses the anatomical and infectious problems of heteroplastic transplantation from a baboon to a man.
(18) The aspect of the condition which is of particular interest is the presence in 3 of the dilated segments of heteroplastic foregut derivatives of unusual varieties.