(1) Fibroblasts from two such TSD patients had Hex A activity comprising 16% of total Hex when measured by thermal fractionation and quantitation with 4-methylumbelliferyl-beta-D-N-acetylglucosamine (4MUG).
(2) We have shown previously that a mutant sequence (hex-3), which differs from hex-1 by three base pairs, can no longer bind these two factors significantly.
(3) About 200 urine samples, from the various categories listed above, were analyzed for Hex A with both the heat denaturation and pH inactivation methods and the results compared with serum and leukocyte levels from many of the same individuals.
(4) Hexosaminidase in extracts from normal kidney and renal carcinoma tissue could be separated into two major forms [hexosaminidase A (Hex A) and hexosaminidase B (Hex B)] by Cellogel electrophoresis or by diethylaminoethyl cellulose column chromatography.
(5) This finding also suggests that the Hex, Mut, and PMS systems evolved from a common ancestor and that functionally similar mismatch repair systems could be widespread among procaryotic as well as eucaryotic organisms.
(6) The greatest amount of hex S activity was found in fibroblast, but it was also observed in lesser amounts in liver, kidney, intestine and placenta.
(7) At low pH, two of the latter mabs reacted only with Hex B, and it was, therefore, possible to develop enzyme immunoassays for the specific determination of Hex A and Hex B.
(8) The competitive ganglionic nicotinic blocking agent, HEX, on the other hand, inhibited both the increased locomotion produced by CRF in the home cage and also the decreased locomotion induced by CRF in the modified open field.
(9) Hex 70-Inv and Hex 532-Inv, like endogenous lysosomal enzymes, were subject to developmentally induced secretion.
(10) A hexose (Hex)2-3 branch is attached to the heptose linked directly to KDO and a GalNAc-Hex3, GlcNAc, and PEA are separately attached to the second heptose.
(11) The commonly used screening test for detection of Tay-Sachs disease (TSD) carriers is the serum Hex heat inactivation method (HIM), which is based on the assumption that Hex A is the only thermolabile component of Hex; However, in the presence of thermolabile Hex B, HIM could lead to false-negative results.
(12) HEX(C) is shown to differ from HEX(A) and HEX(B) in substrate specificity, molecular size and affinity for Concanavalin-A.
(13) The activities of beta-hexosaminidase (HEX), a lysosomal glycosidase, were studied in serum (sHEX) and urine (uHEX) among men with various drinking habits.
(14) The Hex treated dogs and cats exhibited a fall of MAP and CBF with enhancement of CVR.
(15) The electrophoretic pattern of human fibroblast extracts displays three bands (cathode to anode) of hexosaminidase: Hex B, Hex A, Hex C in normal strains, only one B band in Tay-Sachs strains, and only one C band in Sandhoff strains.
(16) Though monkey tissues also cross-reacted with human seminal plasma Hex-antisera, mouse, rat, and goat testis and epididymis extracts failed to show any cross-reaction.
(17) Hex S, the major residual beta hexosaminidase activity present in tissues, fluids, and cultured skin fibroblasts of patients with type 0 GM2 gangliosidosis, was isolated and characterized biochemically and immunologically.
(18) The persistence of a second major hexosaminidase isozyme, HEX B, does not protect against the lethal accumulation of GM2 ganglioside in the central nervous system.
(19) The results suggest that, in the patient's fibroblasts, a defect in beta-chain synthesis or processing precludes the self-association of beta-chains to form Hex B, but does not prevent the association of alpha- and beta-chains to form Hex A.
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Uranium
Definition:
(n.) An element of the chromium group, found in certain rare minerals, as pitchblende, uranite, etc., and reduced as a heavy, hard, nickel-white metal which is quite permanent. Its yellow oxide is used to impart to glass a delicate greenish-yellow tint which is accompanied by a strong fluorescence, and its black oxide is used as a pigment in porcelain painting. Symbol U. Atomic weight 239.
Example Sentences:
(1) These steps signify a willingness for engagement not seen before, but they have been overshadowed by the "nuclear crisis" triggered in October 2002 when Pyongyang admitted to having the "know-how", but not the technology, for a highly enriched uranium route to nuclear weapons.
(2) It paves the way for Iran to get nuclear weapons.” Under the deal, Iran committed to reducing the number of its centrifuges by two-thirds, capping its level of uranium enrichment well below the level needed for bomb-grade material, reducing its enriched uranium stockpile from around 10,000kg to 300kg for 15 years, and submitting to international inspections to verify its compliance.
(3) A simple method for distinction between RNA- and DNA-containing structures in aldehyde- and osmiumtextroxide-fixed electron microscopic autoradiographs (or ordinary thin sections) is described: the developer and the acetic acid used for processing autoradiographs extract selectively uranium acetate from DNA containing-structures which, after staining with lead citrate, leads to a characteristically 'bleached' appearance of the DNA.
(4) When the reactor is running, high-speed particles called neutrons strike the uranium atoms and cause them to split in a process known as nuclear fission.
(5) Lung dissolution of industrial uranium tetrafluoride (UF4) was tested in rats and baboons by intratracheal instillation and inhalation, to check the W classification given to UF4 by the International Commission on Radiological Protection.
(6) We aggressively push new uranium deals to countries like India , whose nuclear industry has been called unsafe by its own auditor general , and which point blank refuses to sign the global nuclear non-proliferation treaty .
(7) A chemist working at Iran's main uranium enrichment plant was killed on Wednesday when attackers on a motorbike stuck a magnetic bomb to his car.
(8) The 20%-enriched uranium stockpile would be at the heart of the new diplomatic effort.
(9) The aim of the present study was to determine whether the nephrotoxicity of the uranium-containing compound uranyl fluoride (UO2F2) is enhanced after unilateral nephrectomy.
(10) After fixing, some specimens were embedded in resin and prepared in ultra thin sections before being triple stained with tannic acid-ethanol uranium-lead.
(11) Among the ideas on the table were cutting Iran’s uranium stockpile, slowing the speed of the centrifuges or reconfiguring them.
(12) He was responsible for securing vital uranium-enrichment technology, photographing centrifuge blueprints that a German executive had been bribed into temporarily "mislaying" in his kitchen.
(13) Obama described the site, apparently a second Iranian facility for enriching uranium, as a "disturbing revelation".
(14) In kidney and bone, only administration of Tiron at 0, 0.25, or 1 hr after uranium injection, or gallic acid at 1 hr after uranium exposure significantly reduced tissue uranium concentrations.
(15) The following correction was printed in the Guardian's Corrections and clarifications column, Saturday November 17 2007 The obituary below said that some of the uranium used in the Little Boy atom bomb was snatched from Soviet-occupied Germany in 1945 by an Anglo-American special unit.
(16) The six powers (US, UK, France, Russia, China and Germany) will make it clearer to Iran that relief from the current severe sanctions regime will be available if Iran stops producing 20%-enriched uranium – a particular proliferation concern as it could easily turned into weapons-grade uranium should Iran take the decision to make a bomb.
(17) Using the Kaplan-Meier method, actuarial survival data were estimated in cancer patients registered in the Cancer Registry of Health Institute of Uranium Industry during 1976-1983, and in those followed up for 3 years and longer after the initiation of their treatment.
(18) Seventy-three rats were exposed to an aerosol of enriched uranium dioxide (UO2), giving initial lung burdens of 26 to 447 micrograms at 6 days post-inhalation (PI).
(19) Does Obama include the right to enrich uranium, which Iran is entitled to do as a signatory of the nuclear non-proliferation treaty?
(20) A future in which Iran doesn’t have a single centrifuge for enriching uranium?