(1) Fibroblasts from two such TSD patients had Hex A activity comprising 16% of total Hex when measured by thermal fractionation and quantitation with 4-methylumbelliferyl-beta-D-N-acetylglucosamine (4MUG).
(2) We have shown previously that a mutant sequence (hex-3), which differs from hex-1 by three base pairs, can no longer bind these two factors significantly.
(3) About 200 urine samples, from the various categories listed above, were analyzed for Hex A with both the heat denaturation and pH inactivation methods and the results compared with serum and leukocyte levels from many of the same individuals.
(4) Hexosaminidase in extracts from normal kidney and renal carcinoma tissue could be separated into two major forms [hexosaminidase A (Hex A) and hexosaminidase B (Hex B)] by Cellogel electrophoresis or by diethylaminoethyl cellulose column chromatography.
(5) This finding also suggests that the Hex, Mut, and PMS systems evolved from a common ancestor and that functionally similar mismatch repair systems could be widespread among procaryotic as well as eucaryotic organisms.
(6) The greatest amount of hex S activity was found in fibroblast, but it was also observed in lesser amounts in liver, kidney, intestine and placenta.
(7) At low pH, two of the latter mabs reacted only with Hex B, and it was, therefore, possible to develop enzyme immunoassays for the specific determination of Hex A and Hex B.
(8) The competitive ganglionic nicotinic blocking agent, HEX, on the other hand, inhibited both the increased locomotion produced by CRF in the home cage and also the decreased locomotion induced by CRF in the modified open field.
(9) Hex 70-Inv and Hex 532-Inv, like endogenous lysosomal enzymes, were subject to developmentally induced secretion.
(10) A hexose (Hex)2-3 branch is attached to the heptose linked directly to KDO and a GalNAc-Hex3, GlcNAc, and PEA are separately attached to the second heptose.
(11) The commonly used screening test for detection of Tay-Sachs disease (TSD) carriers is the serum Hex heat inactivation method (HIM), which is based on the assumption that Hex A is the only thermolabile component of Hex; However, in the presence of thermolabile Hex B, HIM could lead to false-negative results.
(12) HEX(C) is shown to differ from HEX(A) and HEX(B) in substrate specificity, molecular size and affinity for Concanavalin-A.
(13) The activities of beta-hexosaminidase (HEX), a lysosomal glycosidase, were studied in serum (sHEX) and urine (uHEX) among men with various drinking habits.
(14) The Hex treated dogs and cats exhibited a fall of MAP and CBF with enhancement of CVR.
(15) The electrophoretic pattern of human fibroblast extracts displays three bands (cathode to anode) of hexosaminidase: Hex B, Hex A, Hex C in normal strains, only one B band in Tay-Sachs strains, and only one C band in Sandhoff strains.
(16) Though monkey tissues also cross-reacted with human seminal plasma Hex-antisera, mouse, rat, and goat testis and epididymis extracts failed to show any cross-reaction.
(17) Hex S, the major residual beta hexosaminidase activity present in tissues, fluids, and cultured skin fibroblasts of patients with type 0 GM2 gangliosidosis, was isolated and characterized biochemically and immunologically.
(18) The persistence of a second major hexosaminidase isozyme, HEX B, does not protect against the lethal accumulation of GM2 ganglioside in the central nervous system.
(19) The results suggest that, in the patient's fibroblasts, a defect in beta-chain synthesis or processing precludes the self-association of beta-chains to form Hex B, but does not prevent the association of alpha- and beta-chains to form Hex A.
(20) Track listing: What Goes Boom Greens and Blues Indie Cindy Bagboy Magdalena 318 Silver Snail Blue Eyed Hexe Ring the Bell Another Toe in the Ocean Andro Queen Snakes Jaime Bravo Track listing for Live in the USA (feat Lenchantin on bass): Bone Machine Hey Ana Magdalena 318 Snakes Indie Cindy I’ve Been Tired Head On The Sad Punk Distance Equals Rate Times Time Something Against You Isla de Encanta Planet of Sound Reading this on mobile?
Vex
Definition:
(v. t.) To to/s back and forth; to agitate; to disquiet.
(v. t.) To make angry or annoyed by little provocations; to irritate; to plague; to torment; to harass; to afflict; to trouble; to tease.
(v. t.) To twist; to weave.
(v. i.) To be irritated; to fret.
Example Sentences:
(1) De Boer's successor's first tasks will be to keep the US aboard the negotiations and to clear up the vexed question of the legal status of the Copenhagen accord , the deal struck at Copenhagen by a small group but not endorsed by a majority of countries.
(2) There is also the vexed question of what should be the legal form of any Paris agreement, a subject likely to keep negotiators up late into the night at the conference, and some anxiety among the hosts over whether the text of a deal can be formulated in due time.
(3) But the bigger question, the one that has vexed historians, biographers and holocaust experts for eight decades, is why she was there.
(4) Cs (2 mM) reduced diastolic depolarization (DD) at different [Ca]O and in 10.8 mM [Ca]O revealed an oscillatory potential (VOS) and the decay of a prolonged depolarization (Vex).
(5) The past few days have been vexing ones for reporting guidelines, voluntary or legal.
(6) The present data also highlighted the vexed relationship between stress and seizure control, which needs to be further investigated.
(7) Another vexed national question in the coming months will be this one: who is the most worthy winner of BBC Sports Personality of the Year?
(8) Delivery of monoclonal antibodies to solid tumors is a vexing problem that must be solved if these antibodies are to realize their promise in therapy.
(9) Pathologists without considerable experience in the diagnosis of bone tumors find this question especially vexing.
(10) Caffeine (5 mM) abolishes Vos and Ios and increases Vex and Iex (as DOXO does), and adding DOXO slightly increased Vex and Iex.
(11) Posttraumatic joint stiffness is particularly vexing in the small joints.
(12) In this spirit, a vignette is offered from a clinical area in which questions of "health" and "illness" are particularly vexing at present.
(13) Some might argue that our eyes weren't quite on the ball back in '89: never mind the cataclysmic political upheaval in eastern Europe – the results of which still echo around the world – let's devote ourselves to a page concerned with vexed questions such as: why is water wet?
(14) The draft provides scant details on the vexed subject of accountability for emission reduction programmes.
(15) Nowhere was the commission’s balancing act more finely weighted than on the vexed question of bioenergy, which Cañete admitted was “a clear problem”.
(16) The top Chinese negotiator, Xie Zhenhua, said there was also a possibility of advances on the vexed issued of transparency – how to monitor, report and verify each nation's emissions to ensure they are honouring their pledges.
(17) But now it’s Isis who are the insurgents,” leaving the peshmerga with the vexing challenge of defending and holding territory.
(18) On the vexed issue of longer term finance, the Ethiopian prime minister Meles Zenawi presented an offer to reduce developing country demands by 75% to $100bn a year from 2020, in return for guarantees of how the money would be distributed.
(19) Discussed here are some contours of the vexing problem of adequate minority participation in the health professions and a brief discussion of some programs that appear to be working.
(20) After the creed and some Benjamin Britten, and a blessing and a long round of applause, the man charged with holding together the fractious global Anglican communion as it struggles with the vexed issues of women bishops and same-sex marriage processed out of the cathedral and into the bitterly cold spring afternoon.