(v. t.) The act of hindering, or the state of being hindered.
(v. t.) That which hinders; an impediment.
Example Sentences:
(1) The increased hindrance to diffusion of the probing molecules caused by the added solutes is considered as good evidence that the probing molecules diffuse by way of pores filled with water.6.
(2) We develop an analogy between the steric hindrance among receptors detecting randomly placed haptens and the temporary locking of a Geiger counter that has detected a radioactive decay.
(3) The relative reactivities of three o-substituted phenols can be explained in terms of steric hindrance which is minimal for a single o-substituent.
(4) The lower affinity of C8-substituted 7-methyl-1,3-dipropylxanthines can be explained quantitatively with steric hindrance, which C8-substituents experience from the 7-methyl group in these conformations.
(5) A comparison of the antioxidant activities of eight 1,4-naphthoquinones indicated that methyl substitution of C-2, lack of steric hindrance at C-3 or C-5, and (in the case of weak acids) a relatively high pKa are favorable structural features associated with strong antioxidant activity.
(6) However, no steric hindrance can be seen between subunits when the subunits in carbonmonoxy Hb are substituted with the corresponding subunits in deoxy Hb.
(7) This suggests that the one-carbon binding site can accomodate two one-carbon groups simultaneously without serious steric hindrance.
(8) Inter-molecular spread of the conformational change among the molecules of PVX protein was demonstrated in DAS-ELISA, when capture mAb inhibited binding of detecting mAb in the absence of steric hindrance.
(9) 46% of the fatal accidents were caused by crashing against hindrances.
(10) Partial hindrance was observed for the third antibody mAb delta 22.
(11) Intraocular horseradish peroxidase (HRP) accumulated in severed optic axons but was transported with no obvious hindrance in spared axons alongside the lesion.
(12) The molecular areas at which the phase transition occurs under the various experimental conditions, together with a parallel analysis of the hydration states and related molecular areas of the DPPC molecules in multilayers, strongly suggest that the steric hindrance associated with the hydration water of the polar head of DPPC molecules in the monolayer is responsible for the drastic decrease in diffusion coefficient in the liquid-condensed phase.
(13) The spondylodiscites were no hindrance for dorsal lordosing osteotomies and can be treated successfully by means of this static correction and the immobilisation.
(14) At the experiments with the isolated rat hearts, prepared by Langendorff, the anti-arrhythmic dose-effects of the water-soluble antioxidant fenozan from the class of steric-hindrance phenols were studied at condition of regional ischemia and reperfusion, as well as its action on the coronary flow.
(15) Taken together, these results suggest that tonin bound to alpha 1-macroglobulin keeps the active site intact and that inhibition of the enzyme activity is due to a steric hindrance.
(16) Because these inhibitors bind preferentially at the extracellular surface of the transporter, their effects must result from a conformational change rather than from steric hindrance.
(17) We propose that incA, in addition to sequestration, can also restrain replication by causing steric hindrance to the origin function.
(18) Vascular hindrance in muscle, but not hindlimb, was less during nerve stimulation in anemia than at normal Hct.
(19) Intense steric hindrance by introducing an enormously bulky group or complete elimination of the 17 beta-hydroxy group rather decreased the anti-androgenic activity.
(20) Their expertise led to this mess, and would be a hindrance, not a help, in cleaning it up.
Obstacle
Definition:
(v.) That which stands in the way, or opposes; anything that hinders progress; a hindrance; an obstruction, physical or moral.
Example Sentences:
(1) Since the first is balked by the obstacle of deficit reduction, emphasis has turned to the second.
(2) If women psychiatrists are to fill some of the positions in Departments of Psychiatry, which will fall vacant over the next decade, much more attention must be paid to eliminating or diminishing the multiple obstacles for women who chose a career in academic psychiatry.
(3) Counselors who serve pregnant US teens face a number of obstacles in communicating adoption as a positive alternative.
(4) A major obstacle to the characterization of the latter two mechanisms has been the lack of suitable model systems expressing only a single nucleoside transport activity.
(5) These observations suggest that refractive anomalies such as anisometropia that limit high frequency spatial resolution and binocular integration can present a major obstacle to the postnatal development of binocular vision.
(6) The initiation of clinical trials on islet transplantation as a possible therapeutic approach for human diabetes had been blocked by 2 major obstacles.
(7) Venous ectasias and varices which can be encountered, associated with DVA constitute an acquired feature in relation to a venous outlet obstacle.
(8) Despite these obstacles, new technologies, coupled with educational efforts, should allow the computer to emerge as a crucial aid to clinicians in the decade ahead.
(9) Yet experience has disclosed an obstacle to understanding the relationship between cervical cancer and OC use--cervical cancer may be caused by the human papilloma virus transmitted by sexual intercourse.
(10) In this paper something is given of their evolution, diversity, aims and activities; and of the important role they now play in many instances, as well as some of the obstacles to collaboration, co-ordination and integration at different levels of operation--internationally, nationally and locally.
(11) It is no obstacle to perform pre- and postoperative radio- and chemotherapy.
(12) Obstacles to successful treatment include an erratic schedule, mistrust of authority, and uncooperative or aggressive behavior.
(13) One of the main obstacles for the introduction of PCR method to identify HIV1 proviral DNA in routine diagnostic laboratories is the use of radiolabelled oligodeoxynucleotide probes.
(14) Digital culture has hardly helped, adding revenge porn, trolls and stranger-shaming to the list of uncomfortable modern obstacles.
(15) She feared her chances of being offered a place would be diminished by a Brexit vote, and the practical considerations like a visa and funding would be more of an obstacle.
(16) It goes without saying that this won't be easy to achieve, and there are many obstacles to be overcome.
(17) Armstrong recognised no obstacle to his ambitions – not morality, not the law.
(18) Where foreign policy and defence are concerned, Britain’s desire to be taken very seriously is the chief obstacle to it being taken more seriously.
(19) The presence of calcifications within the thyroid cartilage is the major obstacle to US imaging of the larynx and is directly related to age; indeed, only 40% of subjects can be examined at the age of 70.
(20) Facebook Twitter Pinterest Britain needs to talk about the R-word: racism It is also a wakeup call to those who recognise racism only when it is played out like a scene from Django Unchained , those who think that racism has to be some vulgar incident perpetrated only by the backward, ignorant and poorly educated, those who believe that racism has to be an act, rather than a complicated and intangible framework that sets up obstacles.