(1) Anti-synthetic HIRP(957-980) serum HIR-27 was proved to cross-react with HIRP-related proteins in solubilized human placental membranes.
(2) We have investigated insulin responsiveness in relation to insulin sensitivity during sequential hyperglycemic clamping in low insulin responders (LIR), high insulin responders (HIR) and in women with a history of gestational diabetes (GD).
(3) 80% of internalized receptors after 20 min), the internalization in HIR-B cells reaches a maximum (approx.
(4) Human insulin receptor substrate-1 (hIRS-1) cDNAs were cloned from a lambda GT11 expression library using a monoclonal antibody (MAb) produced against a human hepatocellular carcinoma (HCC) cell line (FOCUS).
(5) Within 3 h after exposure to 70 nM insulin, ODC enzyme activity increased approximately 50-fold and mRNA accumulation 3-fold in the HIR 3.5 cells but not in normal fibroblasts.
(6) To further explore the specificity of the IR tyrosine phosphokinase (TPK) domain in IR function, we have altered the human IR (hIR) cDNA to encode truncated insulin-independent TPKs, which are expressed in chinese hamster ovary (CHO) cells as either membrane-anchored or cytosolic proteins.
(7) Glucose disposal and whole body carbohydrate oxidation were markedly lower in NIR and HIR vs. NIS (P less than 0.001 for disposal and oxidation).
(8) Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin receptor (hIR) or a mutated hybrid receptor in which the transmembrane and cytoplasmic domains of hIR were replaced by corresponding domains of the transforming protein p68gag-ros (v-ros) of avian sarcoma virus UR2.
(9) In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro.
(10) Cells expressing 6.4 X 10(3) and 1.25 X 10(6) normal receptors and 2.5 X 10(5) HIR delta CT receptors, as well as control Rat 1 fibroblasts were selected for further analysis.
(11) Highly intensive physical loading suppresses the development of DH and enhances the suppressive effect of staphylococci on SRBC-induced HIR.
(12) Our experiments with the hIR protein have been designed to address a very general question of transmembrane receptor structure and function: What are the roles and interactions of the various deduced structural domains of such molecules in the initiation of the response of cells to extracellular signals?
(13) Mono- and polyauxotrophic mutant of I, II and R-phases by hir, ilv, pro, and mtl markers were obtained by treatment of Sh.
(14) Physical loading of low intensity normalizes staphylococcus-suppressed HIR to SRBC, but produces no effect on staphylococcus-induced DH.
(15) Transfection of normal HIR cDNA produced normal insulin receptors on the plasma membranes in COS 7 cells.
(16) Incubation for 18 hrs with 1 microM insulin resulted in a similar decrease (to approximately 35% of control) of all the hIR mRNA species.
(17) Seven regions of the alpha subunit of human insulin receptor (HIR) were synthesized and examined for their ability to bind radioiodinated insulin.
(18) This cDNA (HIR delta CT), as well as cDNA encoding the complete receptor (HIRc) was transfected into Rat 1 fibroblasts.
(19) To this end the following receptor model system consisting of two receptors was co-expressed in NIH 3T3 cells: a kinase inactive human insulin receptor (HIR K1018A) and a chimeric (EIR) receptor corresponding to the extracellular and transmembrane domains of the human EGF receptor and the cytosolic domain of the human insulin receptor beta subunit.
(20) The resulting virus, named UIR, contains the hIR sequence fused to the 5' portion of the UR2 gag gene coding for p19.
Hire
Definition:
(pron.) See Here, pron.
(n.) The price, reward, or compensation paid, or contracted to be paid, for the temporary use of a thing or a place, for personal service, or for labor; wages; rent; pay.
(n.) A bailment by which the use of a thing, or the services and labor of a person, are contracted for at a certain price or reward.
(n.) To procure (any chattel or estate) from another person, for temporary use, for a compensation or equivalent; to purchase the use or enjoyment of for a limited time; as, to hire a farm for a year; to hire money.
(n.) To engage or purchase the service, labor, or interest of (any one) for a specific purpose, by payment of wages; as, to hire a servant, an agent, or an advocate.
(n.) To grant the temporary use of, for compensation; to engage to give the service of, for a price; to let; to lease; -- now usually with out, and often reflexively; as, he has hired out his horse, or his time.
Example Sentences:
(1) Byrom had been scheduled to die by lethal injection last week for hiring a man to shoot dead her abusive husband, Edward, at their home in Iuka in June 1999.
(2) A team of 16 guides has been hired and trained to give a running commentary on their every move.
(3) China Labor Watch says Samsung is also guilty of bad hiring and working practices.
(4) White House plan to hire more border agents raises vetting fear, ex-senior official says Read more “But the fact is when the world changed, you have to change too, and so I do think there are amazing new opportunities now because he’s bringing nationalism to the fore, he’s bringing it into the mainstream, he’s asking these existential questions like: are we a nation?
(5) The checkpoints are a recipe for harassment and abuse.” Among other moves disclosed were plans to hire 300 extra security guards to secure public transport in the city.
(6) As in Utah, the public sector led the way in response to recession, this time in the early 1990s, by hiring new staff on 80% contracts.
(7) These folk spend in a day what most people earn in a year on hiring hotel suites and setting up temporary fashion-show rooms in the hysterical hope that their wares will attract the eye of that most important person in town that week: the celebrity stylist.
(8) Writers are being hired on new US shows on the basis of their consistently hilarious Twitter accounts (such as Alison Agosti and Bryan Donaldson for Seth Meyers) and where producers Stateside lead, ours are guaranteed to follow.
(9) But she describes Manafort as a “clever hire” by Trump.
(10) A year after hiring, many relationships were found, including professional actual situation with job satisfaction (r = 0.26, P less than 0.05) and alienation with job satisfaction (r = -0.33, P less than 0.01).
(11) Kenyon then moved to Chelsea, where he and Mendes negotiated Mourinho’s hiring as the new manager, the signings of Carvalho and Ferreira to join him from Porto, and Tiago Mendes, from Benfica.
(12) The company hired reputation management lawyers to issue a five-page letter instructing the articles "be amended to reflect the true position".
(13) Funding policies as well as chairmen's hiring policies also play a role here.
(14) The architects, whose initials stand for Robert Matthew Johnson Marshall, said Goodwin had been hired for his international experience.
(15) The self-serving transparency of her malevolence seemed so obvious I didn’t even hire a lawyer to defend myself.” He took a lie detector and passed, Allen said, but Mia Farrow declined to do so.
(16) I wonder, then, if she could tell us whether she believes that the very low bar of being willing to hire women is an indication of anything other than following anti-discrimination laws.
(17) The South Africans were allegedly hired by a company with close ties to Gaddafi, training his presidential guard and handling some of his offshore financial dealings.
(18) Twitter has hired the former Pearson chief executive Dame Marjorie Scardino to be the first woman on its board, after critics rounded on its all-male lineup.
(19) Since then, the percentage of female FTSE 100 directors has grown from 12.5% to 17.3%, but the increase has been almost entirely driven by companies hiring more part-time non-executives.
(20) In August 2007, just three months after quitting BP, he was hired by New York-based energy investment group Riverstone Holdings to run its European business.