(1) Anti-synthetic HIRP(957-980) serum HIR-27 was proved to cross-react with HIRP-related proteins in solubilized human placental membranes.
(2) We have investigated insulin responsiveness in relation to insulin sensitivity during sequential hyperglycemic clamping in low insulin responders (LIR), high insulin responders (HIR) and in women with a history of gestational diabetes (GD).
(3) 80% of internalized receptors after 20 min), the internalization in HIR-B cells reaches a maximum (approx.
(4) Human insulin receptor substrate-1 (hIRS-1) cDNAs were cloned from a lambda GT11 expression library using a monoclonal antibody (MAb) produced against a human hepatocellular carcinoma (HCC) cell line (FOCUS).
(5) Within 3 h after exposure to 70 nM insulin, ODC enzyme activity increased approximately 50-fold and mRNA accumulation 3-fold in the HIR 3.5 cells but not in normal fibroblasts.
(6) To further explore the specificity of the IR tyrosine phosphokinase (TPK) domain in IR function, we have altered the human IR (hIR) cDNA to encode truncated insulin-independent TPKs, which are expressed in chinese hamster ovary (CHO) cells as either membrane-anchored or cytosolic proteins.
(7) Glucose disposal and whole body carbohydrate oxidation were markedly lower in NIR and HIR vs. NIS (P less than 0.001 for disposal and oxidation).
(8) Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin receptor (hIR) or a mutated hybrid receptor in which the transmembrane and cytoplasmic domains of hIR were replaced by corresponding domains of the transforming protein p68gag-ros (v-ros) of avian sarcoma virus UR2.
(9) In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro.
(10) Cells expressing 6.4 X 10(3) and 1.25 X 10(6) normal receptors and 2.5 X 10(5) HIR delta CT receptors, as well as control Rat 1 fibroblasts were selected for further analysis.
(11) Highly intensive physical loading suppresses the development of DH and enhances the suppressive effect of staphylococci on SRBC-induced HIR.
(12) Our experiments with the hIR protein have been designed to address a very general question of transmembrane receptor structure and function: What are the roles and interactions of the various deduced structural domains of such molecules in the initiation of the response of cells to extracellular signals?
(13) Mono- and polyauxotrophic mutant of I, II and R-phases by hir, ilv, pro, and mtl markers were obtained by treatment of Sh.
(14) Physical loading of low intensity normalizes staphylococcus-suppressed HIR to SRBC, but produces no effect on staphylococcus-induced DH.
(15) Transfection of normal HIR cDNA produced normal insulin receptors on the plasma membranes in COS 7 cells.
(16) Incubation for 18 hrs with 1 microM insulin resulted in a similar decrease (to approximately 35% of control) of all the hIR mRNA species.
(17) Seven regions of the alpha subunit of human insulin receptor (HIR) were synthesized and examined for their ability to bind radioiodinated insulin.
(18) This cDNA (HIR delta CT), as well as cDNA encoding the complete receptor (HIRc) was transfected into Rat 1 fibroblasts.
(19) To this end the following receptor model system consisting of two receptors was co-expressed in NIH 3T3 cells: a kinase inactive human insulin receptor (HIR K1018A) and a chimeric (EIR) receptor corresponding to the extracellular and transmembrane domains of the human EGF receptor and the cytosolic domain of the human insulin receptor beta subunit.
(20) The resulting virus, named UIR, contains the hIR sequence fused to the 5' portion of the UR2 gag gene coding for p19.
Hit
Definition:
(pron.) It.
() 3d pers. sing. pres. of Hide, contracted from hideth.
(imp. & p. p.) of Hit
(v. t.) To reach with a stroke or blow; to strike or touch, usually with force; especially, to reach or touch (an object aimed at).
(v. t.) To reach or attain exactly; to meet according to the occasion; to perform successfully; to attain to; to accord with; to be conformable to; to suit.
(v. t.) To guess; to light upon or discover.
(v. t.) To take up, or replace by a piece belonging to the opposing player; -- said of a single unprotected piece on a point.
(v. i.) To meet or come in contact; to strike; to clash; -- followed by against or on.
(v. i.) To meet or reach what was aimed at or desired; to succeed, -- often with implied chance, or luck.
(n.) A striking against; the collision of one body against another; the stroke that touches anything.
(n.) A stroke of success in an enterprise, as by a fortunate chance; as, he made a hit.
(n.) A peculiarly apt expression or turn of thought; a phrase which hits the mark; as, a happy hit.
(n.) A game won at backgammon after the adversary has removed some of his men. It counts less than a gammon.
(n.) A striking of the ball; as, a safe hit; a foul hit; -- sometimes used specifically for a base hit.
Example Sentences:
(1) Philip Shaw, chief economist at broker Investec, expects CPI to hit 5.1%, just shy of the 5.2% reached in September 2008, as the utility hikes alone add 0.4% to inflation.
(2) Sierra Leone is one of the three West Africa nations hit hard by an Ebola epidemic this year.
(3) But the wounding charge in 2010 has become Brown's creation of a structural hole in the budget, more serious than the cyclical hit which the recession made in tax receipts, at least 4% of GDP.
(4) David Cameron last night hit out at his fellow world leaders after the G8 dropped the promise to meet the historic aid commitments made at Gleneagles in 2005 from this year's summit communique.
(5) Hanley Ramirez was hitting behind Michael Young and now he's injured.
(6) Botswana, Kenya, Somalia and the Democratic Republic of the Congo have also been badly hit.
(7) We are better off in.” Out campaigners have claimed that the NHS could be badly hit by a decision to stay in the EU.
(8) What shouldn't get lost among the hits, home runs and the intentional and semi-intentional walks is that Ortiz finally seems comfortable with having a leadership role with his team.
(9) Chris Pavlou, former vice chairman of Laiki, told Channel 4 news that Anastasiades was given little option by the troika but to accept the draconian terms, which force savers to take a hit for the first time in the fifth bailout of a eurozone country.
(10) Macron hit back on Twitter, saying her proposals to take France out of the EU would destroy France’s fishing industry.
(11) VAT increases don't just hit the poor more than the rich, they also hit small firms, threaten retail jobs and, by boosting inflation, could also lead to higher interest rates."
(12) And Norris Cole hits a "good night everybody" three-pointer.
(13) If you’ve escaped the impact of cuts so far , consider yourself lucky, but don’t think that you won’t be affected after the next tranche hits.
(14) Government borrowing has hit a record high for a September.
(15) The weapon is 13 metres long, weighs 60 tonnes and can carry nuclear warheads with up to eight times the destructive capacity of the bombs that hit Hiroshima and Nagasaki in the second world war.
(16) The debate certainly hit upon a larger issue: the tendency for people in positions of social and cultural power to tell the stories of minorities for them, rather than allowing minority communities to speak for themselves.
(17) On the first anniversary of Peach's death I took part in my first ever demonstration where we chanted the names of the six SPG officers who were said to have been hitting people with batons on the street where Peach died.
(18) "Some of the shrapnel went into the arm of the Australian soldier that was hit, another part went into the foot [of the New Zealand soldier]," he told a news conference .
(19) Two short homologous sequences in the rat insulin I enhancer fragment used, IEB2 and IEB1, have been described as playing a dominant role in the regulation of HIT hamster insulinoma cell-specific transcription of the insulin gene (1).
(20) Women on the beat: how to get more female police officers around the world Read more Mortars were, for instance, used on 5 June when Afghan national army soldiers accidentally hit a wedding party on the outskirts of Ghazni, killing eight children.