(1) Anti-synthetic HIRP(957-980) serum HIR-27 was proved to cross-react with HIRP-related proteins in solubilized human placental membranes.
(2) We have investigated insulin responsiveness in relation to insulin sensitivity during sequential hyperglycemic clamping in low insulin responders (LIR), high insulin responders (HIR) and in women with a history of gestational diabetes (GD).
(3) 80% of internalized receptors after 20 min), the internalization in HIR-B cells reaches a maximum (approx.
(4) Human insulin receptor substrate-1 (hIRS-1) cDNAs were cloned from a lambda GT11 expression library using a monoclonal antibody (MAb) produced against a human hepatocellular carcinoma (HCC) cell line (FOCUS).
(5) Within 3 h after exposure to 70 nM insulin, ODC enzyme activity increased approximately 50-fold and mRNA accumulation 3-fold in the HIR 3.5 cells but not in normal fibroblasts.
(6) To further explore the specificity of the IR tyrosine phosphokinase (TPK) domain in IR function, we have altered the human IR (hIR) cDNA to encode truncated insulin-independent TPKs, which are expressed in chinese hamster ovary (CHO) cells as either membrane-anchored or cytosolic proteins.
(7) Glucose disposal and whole body carbohydrate oxidation were markedly lower in NIR and HIR vs. NIS (P less than 0.001 for disposal and oxidation).
(8) Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin receptor (hIR) or a mutated hybrid receptor in which the transmembrane and cytoplasmic domains of hIR were replaced by corresponding domains of the transforming protein p68gag-ros (v-ros) of avian sarcoma virus UR2.
(9) In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro.
(10) Cells expressing 6.4 X 10(3) and 1.25 X 10(6) normal receptors and 2.5 X 10(5) HIR delta CT receptors, as well as control Rat 1 fibroblasts were selected for further analysis.
(11) Highly intensive physical loading suppresses the development of DH and enhances the suppressive effect of staphylococci on SRBC-induced HIR.
(12) Our experiments with the hIR protein have been designed to address a very general question of transmembrane receptor structure and function: What are the roles and interactions of the various deduced structural domains of such molecules in the initiation of the response of cells to extracellular signals?
(13) Mono- and polyauxotrophic mutant of I, II and R-phases by hir, ilv, pro, and mtl markers were obtained by treatment of Sh.
(14) Physical loading of low intensity normalizes staphylococcus-suppressed HIR to SRBC, but produces no effect on staphylococcus-induced DH.
(15) Transfection of normal HIR cDNA produced normal insulin receptors on the plasma membranes in COS 7 cells.
(16) Incubation for 18 hrs with 1 microM insulin resulted in a similar decrease (to approximately 35% of control) of all the hIR mRNA species.
(17) Seven regions of the alpha subunit of human insulin receptor (HIR) were synthesized and examined for their ability to bind radioiodinated insulin.
(18) This cDNA (HIR delta CT), as well as cDNA encoding the complete receptor (HIRc) was transfected into Rat 1 fibroblasts.
(19) To this end the following receptor model system consisting of two receptors was co-expressed in NIH 3T3 cells: a kinase inactive human insulin receptor (HIR K1018A) and a chimeric (EIR) receptor corresponding to the extracellular and transmembrane domains of the human EGF receptor and the cytosolic domain of the human insulin receptor beta subunit.
(20) The resulting virus, named UIR, contains the hIR sequence fused to the 5' portion of the UR2 gag gene coding for p19.
Sir
Definition:
(n.) A man of social authority and dignity; a lord; a master; a gentleman; -- in this sense usually spelled sire.
(n.) A title prefixed to the Christian name of a knight or a baronet.
(n.) An English rendering of the LAtin Dominus, the academical title of a bachelor of arts; -- formerly colloquially, and sometimes contemptuously, applied to the clergy.
(n.) A respectful title, used in addressing a man, without being prefixed to his name; -- used especially in speaking to elders or superiors; sometimes, also, used in the way of emphatic formality.
Example Sentences:
(1) Businesses fleeing Brexit will head to New York not EU, warns LSE chief Read more Amid attempts by Frankfurt, Paris and Dublin to catch possible fallout from London, Sir Jon Cunliffe said it was highly unlikely that any EU centre could replicate the services offered by the UK’s financial services industry.
(2) However the imagery is more complex, because scholars believe it also relates to another cherished pre-Raphaelite Arthurian legend, Sir Degrevaunt who married his mortal enemy's daughter.
(3) At the moment the MPA makes the appointments in consultation with the Met commissioner, Sir Paul Stephenson.
(4) It has also been given to Sir Andrew Large, a former deputy governor of the Bank of England, whose report on lending failures by RBS will also be released on Monday.
(5) There on the street is Young Jo whose last words were, "I am wery symbolic, sir."
(6) It will form part of an investigation launched by the cabinet secretary, Sir Jeremy Heywood, on the orders of David Cameron to determine the British government's actions over the raid on Sikhism's holiest site in Amritsar.
(7) Sir James Crosby, the ITV senior independent non-executive director, explained why the board had opted to retain Grade's services for an extra year: "It was the unanimous view of ITV's independent non-executive directors that it would be in the best interests of the company and its shareholders to ask Michael to extend his time as executive chairman.
(8) Updated at 1.58pm BST 12.43pm BST Sir Malcolm Bruce, MP for Gordon, says there has been "a degree of intransigence" on both sides at Grangemouth, leading to today's closure.
(9) At a private meeting last Tuesday, Hunt assured Cameron and the cabinet secretary, Sir Jeremy Heywood, that he had not been aware that his special adviser, Adam Smith, was systematically leaking information and advice to News Corp about its bid for BSkyB.
(10) Yesterday streams of worshippers and tourists entered Sir Christopher Wren's building for Sunday services, apparently unconcerned by events outside.
(11) With respect to Sir Jimmy, those who proclaim the age of the train rarely get it right.
(12) The Dacre review panel, which included Sir Joseph Pilling, a retired senior civil servant, and the historian Prof Sir David Cannadine, said Britain now had one of the "less liberal" regimes in Europe for access to confidential government papers and that reform was needed to restore some trust between politicians and people.
(13) Facebook Twitter Pinterest Whether Sia, Jason Derulo, Coldplay’s Chris Martin or Sir Elton John is in the passenger seat, Corden plays the part of a real fan with a deep knowledge of their discography.
(14) We have the president of the tribunal, Sir Michael Burton, arguing that his work needs to be done in secret to secure the trust and co-operation of the intelligence services – but what about the trust of the British people and the confidence of the lawyers who seek to establish the rights of ordinary members of the public?
(15) The four members of the committee are all masters of wine, and the chairman is a retired diplomat, Sir David Wright.
(16) The validity of the response of this probe to Y-90 and its clinical application were assessed with a phantom containing varying activities and with biopsy samples obtained from patients being treated with SIR therapy.
(17) Sir James Crosby, the chief executive until 2006, was forced to resign as deputy chairman of the Financial Services Authority after the Treasury select committee produced allegations by a whistleblower that the bank was "going too fast".
(18) Leading figures including the musician Sting, business tycoon Sir Richard Branson and comedian Russell Brand have called for the possession of drugs to be decriminalised.
(19) Sir Philip Green has interesting tax arrangements but far from being labelled morally repugnant in a Mexico TV studio, he has got a government review to head up," she said.
(20) When last week’s scandal broke, Tesco chair Sir Richard Broadbent airily opined: “Things are always unnoticed until they are noticed.” He forgot to mention that that goes double if people are paid to turn a blind eye.