(1) Anti-synthetic HIRP(957-980) serum HIR-27 was proved to cross-react with HIRP-related proteins in solubilized human placental membranes.
(2) We have investigated insulin responsiveness in relation to insulin sensitivity during sequential hyperglycemic clamping in low insulin responders (LIR), high insulin responders (HIR) and in women with a history of gestational diabetes (GD).
(3) 80% of internalized receptors after 20 min), the internalization in HIR-B cells reaches a maximum (approx.
(4) Human insulin receptor substrate-1 (hIRS-1) cDNAs were cloned from a lambda GT11 expression library using a monoclonal antibody (MAb) produced against a human hepatocellular carcinoma (HCC) cell line (FOCUS).
(5) Within 3 h after exposure to 70 nM insulin, ODC enzyme activity increased approximately 50-fold and mRNA accumulation 3-fold in the HIR 3.5 cells but not in normal fibroblasts.
(6) To further explore the specificity of the IR tyrosine phosphokinase (TPK) domain in IR function, we have altered the human IR (hIR) cDNA to encode truncated insulin-independent TPKs, which are expressed in chinese hamster ovary (CHO) cells as either membrane-anchored or cytosolic proteins.
(7) Glucose disposal and whole body carbohydrate oxidation were markedly lower in NIR and HIR vs. NIS (P less than 0.001 for disposal and oxidation).
(8) Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin receptor (hIR) or a mutated hybrid receptor in which the transmembrane and cytoplasmic domains of hIR were replaced by corresponding domains of the transforming protein p68gag-ros (v-ros) of avian sarcoma virus UR2.
(9) In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro.
(10) Cells expressing 6.4 X 10(3) and 1.25 X 10(6) normal receptors and 2.5 X 10(5) HIR delta CT receptors, as well as control Rat 1 fibroblasts were selected for further analysis.
(11) Highly intensive physical loading suppresses the development of DH and enhances the suppressive effect of staphylococci on SRBC-induced HIR.
(12) Our experiments with the hIR protein have been designed to address a very general question of transmembrane receptor structure and function: What are the roles and interactions of the various deduced structural domains of such molecules in the initiation of the response of cells to extracellular signals?
(13) Mono- and polyauxotrophic mutant of I, II and R-phases by hir, ilv, pro, and mtl markers were obtained by treatment of Sh.
(14) Physical loading of low intensity normalizes staphylococcus-suppressed HIR to SRBC, but produces no effect on staphylococcus-induced DH.
(15) Transfection of normal HIR cDNA produced normal insulin receptors on the plasma membranes in COS 7 cells.
(16) Incubation for 18 hrs with 1 microM insulin resulted in a similar decrease (to approximately 35% of control) of all the hIR mRNA species.
(17) Seven regions of the alpha subunit of human insulin receptor (HIR) were synthesized and examined for their ability to bind radioiodinated insulin.
(18) This cDNA (HIR delta CT), as well as cDNA encoding the complete receptor (HIRc) was transfected into Rat 1 fibroblasts.
(19) To this end the following receptor model system consisting of two receptors was co-expressed in NIH 3T3 cells: a kinase inactive human insulin receptor (HIR K1018A) and a chimeric (EIR) receptor corresponding to the extracellular and transmembrane domains of the human EGF receptor and the cytosolic domain of the human insulin receptor beta subunit.
(20) The resulting virus, named UIR, contains the hIR sequence fused to the 5' portion of the UR2 gag gene coding for p19.
Thons
Definition:
Example Sentences:
(1) West Germany (3-5-2): Bodo Illgner; Guido Buchwald, Klaus Augenthaler, Jürgen Kohler; Thomas Berthold, Thomas Hässler, Lothar Matthäus, Olaf Thon, Andreas Brehme; Jürgen Klinsmann, Rudi Völler.
(2) West Germany bring in two impish schemers, Thomas Hässler and Olaf Thon, for Pierre Littbarski and Uwe Bein.
(3) Walker tackled Klinsmann but the ball came to Thon, who ran 25 yards into the box before shifting the ball to the left of the last man Parker and hitting a shot that Shilton had to beat away to his left.
(4) Fashion parades, balls, raffles, and weekly deductions from thousands of workers' pay packets were integral to success of the Cancer Appeal-a-thon in the Illawarra region.
(5) The British Council has also organised a global Dickens read-a-thon , which will see a reading marathon lasting 24 hours in 24 different countries from Albania to Zimbabwe.
(6) Taylor Swift – Shake It Off Perhaps the most telling aspect of Taylor Swift’s “extravaganza adventure-a-thon!”, AKA the Yahoo-sponsored livestream she used to announce her new album 1989 on Monday night, was the way she repeatedly referred to the album as her first proper foray into pop.
(7) A top college recruit, Thon Maker, is petitioning to skip school altogether and go straight to the NBA.
(8) 3.34pm GMT 101 min: Thon, 25 yards out, swooshes a very good shot not too far wide of the near post.
(9) West Germany moved the ball slowly, all the way across the field from right to left, with Thon eventually shifting it down the line to Brehme.
(10) Thon places another accurate penalty into the bottom-right corner.
(11) Matthäus lays the ball back invitingly for Thon, who drags a 25-yard shot well wide of the near post.
(12) Thon has far too much space to take possession on the edge of the D and shape a lovely right-footed curler towards the far post.
(13) Some local artists took this as a sign of the times and called a 24-hour graffiti-thon.
(14) The weekly shout-a-thon that is prime minister's questions was on the list, as was public grandstanding by MPs on benefits cheats, "shirkers", and moral responsibility.
(15) Terry Butcher and Olaf Thon keep their eyes on the ball.
(16) 2.08pm GMT 38 min A patient West German move ends with Hassler finding Thon 25 yards out.
(17) Collective cannabis smoke-a-thons, featuring drumming, juggling and all the chilled-out tropes of stoner culture, did succeed in finessing public perception of marijuana.