(1) Anti-synthetic HIRP(957-980) serum HIR-27 was proved to cross-react with HIRP-related proteins in solubilized human placental membranes.
(2) We have investigated insulin responsiveness in relation to insulin sensitivity during sequential hyperglycemic clamping in low insulin responders (LIR), high insulin responders (HIR) and in women with a history of gestational diabetes (GD).
(3) 80% of internalized receptors after 20 min), the internalization in HIR-B cells reaches a maximum (approx.
(4) Human insulin receptor substrate-1 (hIRS-1) cDNAs were cloned from a lambda GT11 expression library using a monoclonal antibody (MAb) produced against a human hepatocellular carcinoma (HCC) cell line (FOCUS).
(5) Within 3 h after exposure to 70 nM insulin, ODC enzyme activity increased approximately 50-fold and mRNA accumulation 3-fold in the HIR 3.5 cells but not in normal fibroblasts.
(6) To further explore the specificity of the IR tyrosine phosphokinase (TPK) domain in IR function, we have altered the human IR (hIR) cDNA to encode truncated insulin-independent TPKs, which are expressed in chinese hamster ovary (CHO) cells as either membrane-anchored or cytosolic proteins.
(7) Glucose disposal and whole body carbohydrate oxidation were markedly lower in NIR and HIR vs. NIS (P less than 0.001 for disposal and oxidation).
(8) Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin receptor (hIR) or a mutated hybrid receptor in which the transmembrane and cytoplasmic domains of hIR were replaced by corresponding domains of the transforming protein p68gag-ros (v-ros) of avian sarcoma virus UR2.
(9) In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro.
(10) Cells expressing 6.4 X 10(3) and 1.25 X 10(6) normal receptors and 2.5 X 10(5) HIR delta CT receptors, as well as control Rat 1 fibroblasts were selected for further analysis.
(11) Highly intensive physical loading suppresses the development of DH and enhances the suppressive effect of staphylococci on SRBC-induced HIR.
(12) Our experiments with the hIR protein have been designed to address a very general question of transmembrane receptor structure and function: What are the roles and interactions of the various deduced structural domains of such molecules in the initiation of the response of cells to extracellular signals?
(13) Mono- and polyauxotrophic mutant of I, II and R-phases by hir, ilv, pro, and mtl markers were obtained by treatment of Sh.
(14) Physical loading of low intensity normalizes staphylococcus-suppressed HIR to SRBC, but produces no effect on staphylococcus-induced DH.
(15) Transfection of normal HIR cDNA produced normal insulin receptors on the plasma membranes in COS 7 cells.
(16) Incubation for 18 hrs with 1 microM insulin resulted in a similar decrease (to approximately 35% of control) of all the hIR mRNA species.
(17) Seven regions of the alpha subunit of human insulin receptor (HIR) were synthesized and examined for their ability to bind radioiodinated insulin.
(18) This cDNA (HIR delta CT), as well as cDNA encoding the complete receptor (HIRc) was transfected into Rat 1 fibroblasts.
(19) To this end the following receptor model system consisting of two receptors was co-expressed in NIH 3T3 cells: a kinase inactive human insulin receptor (HIR K1018A) and a chimeric (EIR) receptor corresponding to the extracellular and transmembrane domains of the human EGF receptor and the cytosolic domain of the human insulin receptor beta subunit.
(20) The resulting virus, named UIR, contains the hIR sequence fused to the 5' portion of the UR2 gag gene coding for p19.
Whir
Definition:
(v. i.) To whirl round, or revolve, with a whizzing noise; to fly or more quickly with a buzzing or whizzing sound; to whiz.
(v. t.) To hurry a long with a whizzing sound.
(n.) A buzzing or whizzing sound produced by rapid or whirling motion; as, the whir of a partridge; the whir of a spinning wheel.
Example Sentences:
(1) Here's a picture of Mike Ashley's whirly-bird instead.
(2) In a whir of lycra and straining calf muscles, the sleek, bent bodies flashed past, urged on by the crowds.
(3) At night, if you are quiet, you can hear them whirring from the Hills Hoist.
(4) We strolled across springy heather and moss as wet as a sponge, and a strange cackling call of “go-back, go-back” rose on the wind: small coveys of red grouse whirred away from us.
(5) I’m sure the person had a valid reason but it should be clear that the Ka’bah should not suddenly be surrounding by whirring Segways.” A hoverboard is a levitating board that was popularised by Marty McFly in the Back to the Future films.
(6) I see this as the most damaging event for our brand in the company’s 140-year history,” Tanaka said after making a ritual deep bow of contrition while cameras whirred and flashed.
(7) Perhaps, rather than the mystique, it’s the sense of knowledge that keeps them hanging on – that perpetual feeling of opening the city up like a pocket watch and seeing its cogs and springs all whirring away inside.
(8) This happened on Monday when X-Files star Gillian Anderson retweeted a poster made by a fan, imagining her as the new 007 : the actor photoshopped in front of that big iconic whirly gun barrel and the official logo pasted at the bottom.
(9) ‘owl-light’ (Lancashire) fizmer the whispering sound of wind in reeds or grass (Fenland) grimlins the night hours around midsummer when dusk blends into dawn (Orkney) The word-hoard: Robert Macfarlane on rewilding our language of landscape Read more gruffy ground the surface landscape left behind by lead-mining (Somerset) grumma a mirage caused by mist or haze (Shetland) hob-gob a dangerously choppy sea (Suffolk) muxy of land; sticky, miry, muddy (Exmoor) outshifts the fringes and boundaries of a town (Cambridgeshire) roarie-bummlers fast-moving storm clouds (Scots) snow-bones long thin patches of snow still lying after a thaw, often in dips or stream-cuts (Yorkshire) turn-whol a deep and seething pool where two quick streams meet (Cumbria) zwer the whirring sound made by a covey of partridge taking flight (Exmoor)
(10) The two other videos uploaded to the account are titled “natural hallucinogen 2x (faster and better trip)” and “natural hallucinogen slow motion (stronger and longer trip),” and depict whirring graphics.
(11) But these exchanges are not places either: they are server farms, air-conditioned warehouses filled with rack-mounted computers, complete with blinking lights and whirring discs.
(12) For the most part the only sound we hear is the whirring of our wheels and birdsong.
(13) That craft whirred into view at 9.50am – cutting it fine for a 10 o'clock meeting, but you know what?
(14) "These guys have to be super-smart and super-dedicated," says one manager against the blinking lights and whirring fans.
(15) While assembling Room 237, the director found himself watching The Shining again and again, his brain whirring, his senses in uproar.
(16) He cut up a 10-volume illustrated Larousse encyclopaedia he'd bought in Bath, apparently using 32 pairs of scissors, and his collage technique helps depict such Thomas phrases as "slow clocks" (cue for several whirring time-pieces) or "the boys are dreaming wicked" (two pin-ups and touches of a Wild West rodeo).
(17) But the questions raised by the women's movements whirred around her mind.
(18) But against the odds, the cassette has whirred into fabulous life again, and on 7 September, an international event will celebrate its resurgence.
(19) He may succeed in crippling al-Qaida and preventing some attacks today, but it is now harder than ever to believe that a young child in Pakistan hearing the whirring noises of drones above them will look up and see Obama's America as "the relentless opponent of terror and tyranny, and the light of hope to the world" .
(20) The wingless whirly-bird which brought Danny Graham and his agent to Sunderland is unable to take off because of windy weather conditions.