(1) Anti-synthetic HIRP(957-980) serum HIR-27 was proved to cross-react with HIRP-related proteins in solubilized human placental membranes.
(2) We have investigated insulin responsiveness in relation to insulin sensitivity during sequential hyperglycemic clamping in low insulin responders (LIR), high insulin responders (HIR) and in women with a history of gestational diabetes (GD).
(3) 80% of internalized receptors after 20 min), the internalization in HIR-B cells reaches a maximum (approx.
(4) Human insulin receptor substrate-1 (hIRS-1) cDNAs were cloned from a lambda GT11 expression library using a monoclonal antibody (MAb) produced against a human hepatocellular carcinoma (HCC) cell line (FOCUS).
(5) Within 3 h after exposure to 70 nM insulin, ODC enzyme activity increased approximately 50-fold and mRNA accumulation 3-fold in the HIR 3.5 cells but not in normal fibroblasts.
(6) To further explore the specificity of the IR tyrosine phosphokinase (TPK) domain in IR function, we have altered the human IR (hIR) cDNA to encode truncated insulin-independent TPKs, which are expressed in chinese hamster ovary (CHO) cells as either membrane-anchored or cytosolic proteins.
(7) Glucose disposal and whole body carbohydrate oxidation were markedly lower in NIR and HIR vs. NIS (P less than 0.001 for disposal and oxidation).
(8) Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin receptor (hIR) or a mutated hybrid receptor in which the transmembrane and cytoplasmic domains of hIR were replaced by corresponding domains of the transforming protein p68gag-ros (v-ros) of avian sarcoma virus UR2.
(9) In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro.
(10) Cells expressing 6.4 X 10(3) and 1.25 X 10(6) normal receptors and 2.5 X 10(5) HIR delta CT receptors, as well as control Rat 1 fibroblasts were selected for further analysis.
(11) Highly intensive physical loading suppresses the development of DH and enhances the suppressive effect of staphylococci on SRBC-induced HIR.
(12) Our experiments with the hIR protein have been designed to address a very general question of transmembrane receptor structure and function: What are the roles and interactions of the various deduced structural domains of such molecules in the initiation of the response of cells to extracellular signals?
(13) Mono- and polyauxotrophic mutant of I, II and R-phases by hir, ilv, pro, and mtl markers were obtained by treatment of Sh.
(14) Physical loading of low intensity normalizes staphylococcus-suppressed HIR to SRBC, but produces no effect on staphylococcus-induced DH.
(15) Transfection of normal HIR cDNA produced normal insulin receptors on the plasma membranes in COS 7 cells.
(16) Incubation for 18 hrs with 1 microM insulin resulted in a similar decrease (to approximately 35% of control) of all the hIR mRNA species.
(17) Seven regions of the alpha subunit of human insulin receptor (HIR) were synthesized and examined for their ability to bind radioiodinated insulin.
(18) This cDNA (HIR delta CT), as well as cDNA encoding the complete receptor (HIRc) was transfected into Rat 1 fibroblasts.
(19) To this end the following receptor model system consisting of two receptors was co-expressed in NIH 3T3 cells: a kinase inactive human insulin receptor (HIR K1018A) and a chimeric (EIR) receptor corresponding to the extracellular and transmembrane domains of the human EGF receptor and the cytosolic domain of the human insulin receptor beta subunit.
(20) The resulting virus, named UIR, contains the hIR sequence fused to the 5' portion of the UR2 gag gene coding for p19.
Hiss
Definition:
(v. i.) To make with the mouth a prolonged sound like that of the letter s, by driving the breath between the tongue and the teeth; to make with the mouth a sound like that made by a goose or a snake when angered; esp., to make such a sound as an expression of hatred, passion, or disapproval.
(v. i.) To make a similar noise by any means; to pass with a sibilant sound; as, the arrow hissed as it flew.
(v. t.) To condemn or express contempt for by hissing.
(v. t.) To utter with a hissing sound.
(n.) A prolonged sound like that letter s, made by forcing out the breath between the tongue and teeth, esp. as a token of disapprobation or contempt.
(n.) Any sound resembling that above described
(n.) The noise made by a serpent.
(n.) The note of a goose when irritated.
(n.) The noise made by steam escaping through a narrow orifice, or by water falling on a hot stove.
Example Sentences:
(1) There is the sound of engines hissing and crackling, which have been mixed to seem as near to the ear as the camera was to the cars; there is a mostly unnoticeable rustle of leaves in the trees; periodically, so faintly that almost no one would register it consciously, there is the sound of a car rolling through an intersection a block or two over, off camera; a dog barks somewhere far away.
(2) When Trump described her father as a “tremendous champion of supporting families”, there were boos and hisses.
(3) Even if we have to wait in line for a hissing coffee machine.
(4) Feline affective defense behavior, characterized mainly by autonomic arousal, ear retraction, growling, hissing and paw striking, was elicited by electrical stimulation of the ventromedial hypothalamic nucleus (VMH).
(5) Ragged-red fibers with abnormal mitochondria, cerebral spongiosis mostly involving white matter, perimacular pigmentary retinopathy and scattered myocardial fibrosis interrupting the Hiss'bundle were found.
(6) Mutants that require histidine due to an altered structural gene for the histidyl-transfer ribonucleic acid synthetase (hisS) have been isolated by a general selection for histidine-requiring strains in which the mutation producing histidine auxotrophy is unlinked to the histidine operon.
(7) If that happens, Osborne will get the blame as the hissing becomes deafening.
(8) Other factors hiss their message more perniciously.
(9) Sure, the season’s story, which focuses on Vanessa Ives’s struggle to decode the “memoirs of the devil” and fight a hissing viper pit of Lucifer’s witches, may be pure pulp burlesque, but that’s just the first layer of Penny Dreadful’s charm.
(10) Supporters of the Tunisian national football team whistle and hiss at the French national anthem before the match.
(11) Hissing and directed attack were selected for threshold determination.
(12) The earphones were with Eva, 11, who was listening to the soundtrack of Glee at a loud enough level to produce that particularly annoying mixture of hiss and thud.
(13) For the 30 years I have followed Spurs to away games – in pubs, around tube stations, on the streets around the ground and within Stamford Bridge itself, the venom, ignorance and breathtaking casualness of Chelsea fans’ references to Jews, Auschwitz, the Holocaust and foreskins, often accompanied by a hissing simulation of gas chambers, is simply shocking – not least because it goes unchallenged by police, stewards or the club itself, bar a token reference furtively hidden away in the match-day programme.
(14) Most tourists satisfy themselves with a quick drive around the crater rim, stopping for photos at the viewing points, but if you really want to smell the sulphur, feel the heat of the lava and hear the hissing of the steam vents, a bike tour is perfect.
(15) Arthur had a hapless sidekick, Chester Drawers, who he’d humiliate roundly in front of an audience, then come off stage and double down on by hissing something like: “I’ve seen a monkey take a pie better than that!” Will May’s government soon be forced to undergo an emergency Borisectomy?
(16) The injection of the D1-selective antagonist SCH 23390 (0.3 nmol), however, did not inhibit apomorphine-induced facilitation of hissing.
(17) The somatic and autonomic displays which accompanied defensive behavior were similar between stimuli, consisting of mydriasis, piloerection, growling, hissing and paw strikes.
(18) (“He took the cork out and spilled a little on the wooden plank of the pier; it hissed like steam.”) Only later in the last century did the crime begin to be associated with the developing rather than the developed rather than the developed world, as a function of male oppression and feudalism, rather than the green-eyed cruelty of richer societies.
(19) That said, as we make our way up the stairs he lets out a hiss of air.
(20) Air hissed out, leading to normalisation of arterial and venous pressures.