(1) HOE was the most active compound, being able to accelerate PIP2 breakdown at concentrations between 10(-12) and 10(-6) M, while in the case of HEE the effective doses ranged from 10(-11) to 10(-7) M and from 10(-9) to 10(-6) M in the case of HNE.
(2) The coding region for a secreted proteinaceous inhibitor of the human alpha-amylase (tendamistat; HOE 467) was identified by using a synthetic oligonucleotide probe.
(3) A carcinogenicity study with the LH-RH analog buserelin (HOE 766) was conducted in male and female Wistar rats.
(4) They show HOE 077 to be a promising agent for the inhibition of hepatic fibrosis.
(5) S 0885 and HOE 077 inhibit CCl4-induced liver fibrosis in rats, as shown by significantly reduced hydroxyproline content of the liver and improved liver histology.
(6) A double-blind cross-over study of the effects of HOE 760 (histamine H2-receptor blocker) on diazepam pharmacokinetics was conducted in 12 healthy men.
(7) In addition, the stability of the kinin antagonist, Hoe 140, in synovial fluid was compared with that of synthetic bradykinin.
(8) The addition of increasing concentrations of Hoe 760 to the histamine concentration-response curve caused a parallel rightward shift.
(9) However, the effect of intravenous Hoe 490 was only half as intense as that of HB 419 in the first hours after treatment and the effect of oral Hoe 490 was initially stronger and thereafter temporarily distinctly weaker than that of HB 419.
(10) Studies on absorption and distribution in both skin and organism, as well as on elimination and biotransformation were performed in rats, pigs, and rabbits following topical application of the corticoid prednisolone-17-ethyl carbonate-21-propionate (prednicarbate; test name: Hoe 777), which had been labeled with 14C in position 4 for this purpose.
(11) Mode of action studies were made with Hoe 296, a new synthetic antimycotic, mainly in Candida albicans.
(12) Treatment with ramipril plus the BK B2-receptor antagonist HOE 140 for 6 weeks significantly attenuated the antihypertensive effects of the ACE-inhibitor in 2K1C hypertensive WI rats, but not in 2K1C hypertensive BN-K rats and in SHR.
(13) Partial inhibition by relatively high concentrations of Hoe 296 of the respiratory activity of yeast cells or mitochondria therefrom with exogenous substrates can be explained by decreased uptake of the substrates from the medium.
(14) HOE 077 wa rapidly and completely absorbed after oral administration.
(15) Hoe 065 prevented the disruption of memory induced by scopolamine administered before training.
(16) Preincubation of the detector cells with Hoe 140 completely abolished this nitric oxide release.
(17) The organ distribution of the 125I-labelled (3-9)-heptapeptide fragments was similar to LH-RH, but not to Hoe 766.
(18) The decrease of cardiac activity in Rhesus monkeys amounted to 69% in 24 h, whereas proscillaridin A decreased cardiac activity only by 41% in 24 h. The absorption of HOE 040 from the duodenum of dogs anesthetized with pentobarbital amounted to 72%, whereas proscillaridin A is observed by only between 14 and 25%.
(19) We have developed a neutral human insulin (Hoe 21 GH) which is stabilized for use in implantable roller pumps.
(20) A radioimmunoassay for HOE 766 was developed using 125I[D-Trp6,Des-Gly10]GnRH ethylamide as tracer and an antiserum raised against HOE 766.
Honing
Definition:
(p]. pr. & vb. n.) of Hone
Example Sentences:
(1) And it will continue to refine and hone the operation: recruiting more volunteers, collecting more data, refining the methods of communication, using social media more than traditional media.
(2) Interview with Donald Hutera In other words "Maliphant's choreography slips under our guard, arouses our curiosity and hones our gaze, without us realising the force of its aim."
(3) However, the wise surgeon will continue to hone his surgical skills because the results of definitive, sure, and deliberate operative treatment of biliary tract stone disease remains the standard by which newer methods must be gauged.
(4) Drilling and polluting is what Shell does, and its corporate culture – honed in blackspots such as Nigeria and the Alberta tar sands – is still based on the old 19th-century explore-exploit-risk-reward capitalist business model that owes nothing to anything beyond the company.
(5) His links with Bach have been the subject of much speculation among the German media, which has also honed in on Bach’s trade links to the middle east in his business life and his past as an executive for Adidas and Siemens.
(6) David Hone, climate change adviser for oil company Shell, said policy makers needed to focus on delivering a clear carbon price, rather than setting targets for renewable energy.
(7) The music and the image had been honed down in the interim – the gear to the archetypal indie look and the music to the almost bubblegum sound which they ply today.
(8) These tactics, of low-visibility, close-quarters combat were honed while fighting the Russians.
(9) V&A museum project boosted by billionaire's donation Read more The studious reproduction of museum exhibits has long been a fundamental part of art education – a means of honing drawing skills and offering deeper ways of looking.
(10) He offers a simple, well-honed defence to convince both himself and his interrogators of his innocence: "I made it to protect the motherland.
(11) In Venezuela, for example, mannequins’ shape have changed in response to the exaggerated ideals of beauty promoted in a country where a plastic surgery-honed physique is the ideal.
(12) The latest revelation about the involvement of blacklisting on the Olympic site is contained in a letter sent to Olympic Delivery Authority (ODA) chief executive Dennis Hone from Balfour Beatty construction chief executive Mike Peasland.
(13) Inside, athletes honed to physical perfection by years of hard work and drugs.
(14) 7.55am GMT Roux is honing in on Johnson’s notes from the night of Reeva Steenkamp’s death.
(15) Alongside the many other scientists, academics and educators on the advisory panel for Atmosphere, David Hone, Shell’s climate change adviser, has been consulted with regards to gallery content,” the spokesperson said.
(16) The HNE-1 cell line has been passaged more than 100 times and the uncloned HONE-1 cells more than 90 times.
(17) He caught sight of Marine Le Pen on a TV politics show in 2007, inveighing against the European Union in the pugnacious style she honed as a lawyer, warning the government to “stop taking the people for fools”.
(18) The key axis in this team is perhaps the Messi-Gago funnel, a relationship honed over shared international adolescence.
(19) Hollande's image as France's Monsieur Normal may have been honed through his contact with the Corrèziens, but it has become one of the foundation stones of his entire election campaign.
(20) They attribute the movement's interest in this issue to a desire to "improve its image, hone its legal strategy, and make new friends" among advocates for the disabled.