(n.) A hollow place or cavity; an excavation; a pit; an opening in or through a solid body, a fabric, etc.; a perforation; a rent; a fissure.
(n.) An excavation in the ground, made by an animal to live in, or a natural cavity inhabited by an animal; hence, a low, narrow, or dark lodging or place; a mean habitation.
(n.) To cut, dig, or bore a hole or holes in; as, to hole a post for the insertion of rails or bars.
(n.) To drive into a hole, as an animal, or a billiard ball.
(v. i.) To go or get into a hole.
Example Sentences:
(1) But the wounding charge in 2010 has become Brown's creation of a structural hole in the budget, more serious than the cyclical hit which the recession made in tax receipts, at least 4% of GDP.
(2) Undaunted by the sickening swell of the ocean and wrapped up against the chilly wind, Straneo, of Woods Hole Oceanographic Institution, one of the world's leading oceanographic research centres, continues to take measurements from the waters as the long Arctic dusk falls.
(3) The speed of visiting holes and the development of a preferred pattern of hole-visits did not influence spatial discrimination performance.
(4) Macular holes, formerly believed to be rare in these injuries, were found in two of the five patients.
(5) Jane's life clearly still has a massive Spike-shaped hole in it.
(6) It would cost their own businesses hundreds of millions of pounds in transaction costs, it would blow a massive hole in their balance of payments, it would leave them having to pick up the entirety of UK debt.
(7) Bar manager Joe Mattheisen, 66, who has worked at the hole-in-the-wall bar since 1997, said the bar has attracted younger, straighter crowds in recent years.
(8) Guzmán was sent to Altiplano high-security prison, 56 miles outside Mexico City, but in July 2015, he absconded again, squeezing through a hole in his shower floor then fleeing on a modified motorbike through a mile-long tunnel fitted with lights and a ventilation system.
(9) If the attacker's plan was to make important ideas disappear down the memory hole, it looks as if it has backfired spectacularly.
(10) In contrast, eyes with macular holes had a greater reduction in the steady-state VEP amplitude than eyes with optic neuritis.
(11) An 8-French right Judkins guiding catheter with a single side hole (USCI), a 3.0 mm balloon dilatation catheter (ACS), and a 0.018 high torque floppy guide wire (ACS) were used.
(12) Four hours p.i., a clustering of the p60 antigen and, 12 h p.i., a formation of finger-like holes, penetrating the nucleus, occurred.
(13) Campbell, Ann E. (Woods Hole Oceanographic Institution, Woods Hole, Mass.
(14) We don't whip homeless vagrants out of town any more, or burn big holes in their ears, as in the brutish 16th century.
(15) The chancellor deliberately made cautious assumptions for the deficit in the budget, but the 5.6% contraction in the economy has blown an even bigger hole in the public finances than feared in April.
(16) He avoided everyone he didn't want to see when he was in Hong Kong, the first place he escaped to, and for several weeks he remained beyond the reach of the world's media, and doubtless a small army of spies, while holed up in a hotel room in the transit area of Moscow's Sheremetyevo airport.
(17) There were no thromboses among infants with long end-hole catheters while infants with short end-hole catheters had thrombosis in 26%, long side-hole catheters in 33% and short side-hole catheters in 64%.
(18) The animal model was induced by left frontal burr hole opening and inoculation of a small piece of G-XII glioma tissue to 6- to 8-week-old rats.
(19) In February last year the BBC was forced to apologise to the Mexican ambassador after a joke made by the three presenters that the nation's cars were like the people "lazy, feckless, flatulent, overweight, leaning against a fence asleep looking at a cactus with a blanket with a hole in the middle on as a coat".
(20) Thus, VP2 and VP5 together form a continuous layer around the inner shell except for holes on the 5-fold axis.
Keyhole
Definition:
(n.) A hole or apertupe in a door or lock, for receiving a key.
(n.) A hole or excavation in beams intended to be joined together, to receive the key which fastens them.
(n.) a mortise for a key or cotter.
Example Sentences:
(1) This effect appeared to be related to dose, and was clearly demonstrable with antibody-forming spleen cells from mice that had been immunized either with sheep red blood cells or with penicillin G conjugated with Keyhole limpet hemocyanin.
(2) The control, uninfected rats make vigorous primary and secondary antibody responses when challenged with keyhole limpet haemocyanin (KLH), human immunoglobulin (HuIg) or sheep red blood cells (SRBC).
(3) BDF1 mice were immunized with a protein antigen, such as ovalbumin (OA) or keyhole limpet hemocyanin (KLH), absorbed to aluminum hydroxide gel, and their spleen cells were stimulated by homologous antigen for the formation of glycosylation-enhancing factor (GEF).
(4) "In an age where people can receive organ transplants, keyhole surgeries and targeted cancer treatments, it's really disappointing that the basic care needs of many young people with physical disabilities and other long-term health needs are not being met," added Field, a GP and ex-chair of the Royal College of GPs .
(5) When I had that keyhole surgery, I thought: ‘Maybe, if I come back, it won’t be to that top level.’ But with the support I have been getting from my coach, family and friends, I think that really motivated me to come back strong.” Kenya is more famed for its distance runners and steeplechasers than its hurdlers, but the country was left celebrating a surprise gold medal in the 400m hurdles when Nicholas Bett powered home from lane nine to smash his personal best to win in 47.79sec.
(6) The antibody responses of animals immunised with keyhole limpet hemocyanin (KLH) in Freund's Incomplete Adjuvant (FIA), diethylaminoethyl dextran (DEAE-dextran) and aluminium hydroxide (alum) were compared with the response to antigen administered in the absence of adjuvants.
(7) In addition to this HIV-specific B cell activation, the number of lymphocytes reactive with nonviral antigens such as DNA, myosin, actin, trinitrophenylated keyhole limpet hemocyanin, and ovalbumin was increased by a mean of 17.9-fold.
(8) Synthetic 131-149 and 140-149 sequences afforded 50 to 80% protection, both in the free state and conjugated with keyhole limpet hemocyanin.
(9) Feeding mice with OA or keyhole limpet haemocyanin in liposomes in a series of priming and boosting regimes failed to elicit any significant increase in serum or intestinal antibody response compared with feeding the free antigen.
(10) A tetrodotoxin-formaldehyde-keyhole limpet hemocyanin conjugate was used to immunize a rabbit for the production of anti-toxin antiserum.
(11) A panel of syngeneic monoclonal anti-idiotypic antibodies was prepared by immunizing A.SW mice with keyhole limpet hemocyanin-coupled A.SW monoclonal anti-myoglobin (HAL 19, IgG1) and screening the cloned hybridomas for production of IgG2 binding to idiotype but not to certain other anti-myoglobin antibodies of the same subclass in an ELISA.
(12) In admixture experiments, spleen cells from microfilaremic animals suppressed the proliferative responsiveness of cells from keyhole limpet hemocyanin (KLH)-immunized jirds to KLH by 38%, but had no effect on KLH-specific antibody production.
(13) B cells from these mice were transferred to irradiated recipients with T cells from keyhole limpet hemocyanin (KLH)-primed mice.
(14) In the absence of exogenous oleic acid (18:1), splenocytes responded to a T-dependent (TD) Ag (trinitrophenyl-keyhole limpet hemocyanin, TNP-KLH) at 37 degrees C but not at 27 degrees C. The addition of 150 microM 18:1 almost completely restored plaque-forming cell (PFC) responses to TNP-KLH at 27 degrees C but markedly suppressed PFC responses to the TD Ag at 37 degrees C. 3.
(15) Two forces are necessary and sufficient to produce the transformation of the newt neural plate from a hemispheric sheet of cells one cell thick to a keyhole shape.
(16) Fit metal, disc-shaped covers over keyholes and install a letterbox brush.
(17) Studying cellular immunocompetence we investigated the skin reactivity to various recall antigens (Candida, Trichophytin, Mumpsantigen, Streptokinase-Streptodornase, PPD), the primary immune response to Dinitrochlorobenzene (DNCB) and Keyhole Limpet Hemocyanin (KLH), and the lymphocyte transformation induced by mitogens (Phytohemagglutinin, Concanavaline A, Pokeweed Mitogen) and specific antigens.
(18) The peptide-keyhole limpet hemocyanin conjugates were used to immunize rabbits.
(19) have reported that the keyhole limpet hemocyanin (KLH)-specific suppressor factor is coded for by the I-J subregion of the H-2 complex (11).
(20) It was found that 2-3% of splenic T cells from arsonate-immune mice specifically bound the hapten using immunofluorescent keyhole limpet hemocyanin as a carrier.