(n.) A hollow place or cavity; an excavation; a pit; an opening in or through a solid body, a fabric, etc.; a perforation; a rent; a fissure.
(n.) An excavation in the ground, made by an animal to live in, or a natural cavity inhabited by an animal; hence, a low, narrow, or dark lodging or place; a mean habitation.
(n.) To cut, dig, or bore a hole or holes in; as, to hole a post for the insertion of rails or bars.
(n.) To drive into a hole, as an animal, or a billiard ball.
(v. i.) To go or get into a hole.
Example Sentences:
(1) But the wounding charge in 2010 has become Brown's creation of a structural hole in the budget, more serious than the cyclical hit which the recession made in tax receipts, at least 4% of GDP.
(2) Undaunted by the sickening swell of the ocean and wrapped up against the chilly wind, Straneo, of Woods Hole Oceanographic Institution, one of the world's leading oceanographic research centres, continues to take measurements from the waters as the long Arctic dusk falls.
(3) The speed of visiting holes and the development of a preferred pattern of hole-visits did not influence spatial discrimination performance.
(4) Macular holes, formerly believed to be rare in these injuries, were found in two of the five patients.
(5) Jane's life clearly still has a massive Spike-shaped hole in it.
(6) It would cost their own businesses hundreds of millions of pounds in transaction costs, it would blow a massive hole in their balance of payments, it would leave them having to pick up the entirety of UK debt.
(7) Bar manager Joe Mattheisen, 66, who has worked at the hole-in-the-wall bar since 1997, said the bar has attracted younger, straighter crowds in recent years.
(8) Guzmán was sent to Altiplano high-security prison, 56 miles outside Mexico City, but in July 2015, he absconded again, squeezing through a hole in his shower floor then fleeing on a modified motorbike through a mile-long tunnel fitted with lights and a ventilation system.
(9) If the attacker's plan was to make important ideas disappear down the memory hole, it looks as if it has backfired spectacularly.
(10) In contrast, eyes with macular holes had a greater reduction in the steady-state VEP amplitude than eyes with optic neuritis.
(11) An 8-French right Judkins guiding catheter with a single side hole (USCI), a 3.0 mm balloon dilatation catheter (ACS), and a 0.018 high torque floppy guide wire (ACS) were used.
(12) Four hours p.i., a clustering of the p60 antigen and, 12 h p.i., a formation of finger-like holes, penetrating the nucleus, occurred.
(13) Campbell, Ann E. (Woods Hole Oceanographic Institution, Woods Hole, Mass.
(14) We don't whip homeless vagrants out of town any more, or burn big holes in their ears, as in the brutish 16th century.
(15) The chancellor deliberately made cautious assumptions for the deficit in the budget, but the 5.6% contraction in the economy has blown an even bigger hole in the public finances than feared in April.
(16) He avoided everyone he didn't want to see when he was in Hong Kong, the first place he escaped to, and for several weeks he remained beyond the reach of the world's media, and doubtless a small army of spies, while holed up in a hotel room in the transit area of Moscow's Sheremetyevo airport.
(17) There were no thromboses among infants with long end-hole catheters while infants with short end-hole catheters had thrombosis in 26%, long side-hole catheters in 33% and short side-hole catheters in 64%.
(18) The animal model was induced by left frontal burr hole opening and inoculation of a small piece of G-XII glioma tissue to 6- to 8-week-old rats.
(19) In February last year the BBC was forced to apologise to the Mexican ambassador after a joke made by the three presenters that the nation's cars were like the people "lazy, feckless, flatulent, overweight, leaning against a fence asleep looking at a cactus with a blanket with a hole in the middle on as a coat".
(20) Thus, VP2 and VP5 together form a continuous layer around the inner shell except for holes on the 5-fold axis.
Role
Definition:
(n.) A part, or character, performed by an actor in a drama; hence, a part of function taken or assumed by any one; as, he has now taken the role of philanthropist.
Example Sentences:
(1) The role of the family practitioner in antenatal care is discussed.
(2) The high amino acid levels in the cells suggest that these cells act as inter-organ transporters and reservoirs of amino acids, they have a different role in their handling and metabolism from those of mammals.
(3) These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens.
(4) In this study, the role of psychological make-up was assessed as a risk factor in the etiology of vasospasm in variant angina (VA) using the Cornell Medical Index (CMI).
(5) The role of Ca2+ in cell agglutination may be either to activate the cell-surface dextran receptor or to form specific intercellular Ca2+ bridges.
(6) The role of whole Mycobacteria, mycobacterial cell walls and waxes D as immunostimulants was well established many years ago.
(7) We have investigated a physiological role of endogenous insulin on exocrine pancreatic secretion stimulated by a liquid meal as well as exogenous secretin and cholecystokinin octapeptide (CCK-8) in conscious rats.
(8) The data indicate that ebselen is likely to be useful in the therapy of inflammatory conditions in which reactive oxygen species, such as peroxides, play an aetiological role.
(9) We have examined the insertion of bovine 17 alpha-hydroxylase (P45017 alpha) into the endoplasmic reticulum of COS 1 cells to evaluate the functional role of its hydrophobic amino-terminal sequence and membrane insertion.
(10) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(11) gamma-Aminobutyric acid (GABA) and glutamate release from the treated side was higher than the control value during the first 2-3 h, a result indicating an important role of glial cells in the inactivation of released transmitter.
(12) Although antihistamines are widely used for symptomatic treatment of seasonal (allergic) rhinitis, the role of histamines in the pathogenesis of infectious rhinitis is not clear.
(13) Because many wnt genes are also expressed in the lung, we have examined whether the wnt family member wnt-2 (irp) plays a role in lung development.
(14) As prolongation of the action potential by TEA facilitates preferentially the hormone release evoked by low (ineffective) frequencies, it is suggested that a frequency-dependent broadening of action potentials which reportedly occurs on neurosecretory neurones may play an important role in the frequency-dependent facilitation of hormone release from the rat neurohypophysis.
(15) The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of O2 radicals and an inhibitor of xanthine oxidase.
(16) A possible role for mitochondria in myocardial adenosine production is discussed.
(17) Further studies are required to elucidate specific roles of the steroid-induced proteins in the effects of glucocorticoids on HTM and HS cells.
(18) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(19) The manufacturers, British Aerospace describe it as a "single-seat, radar equipped, lightweight, multi-role combat aircraft, providing comprehensive air defence and ground attack capability".
(20) The presently available data allow us to draw the following conclusions: 1) G proteins play a mediatory role in the transmission of the signal(s) generated upon receptor occupancy that leads to the observed cytoskeletal changes.